DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sur-8 and LRRC7

DIOPT Version :9

Sequence 1:	NP_001262665.1	Gene:	Sur-8 / 42093	FlyBaseID:	FBgn0038504	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_001357714.1	Gene:	LRRC7 / 57554	HGNCID:	18531	Length:	1575	Species:	Homo sapiens

Alignment Length:	508	Identity:	151/508 - (29%)
Similarity:	229/508 - (45%)	Gaps:	96/508 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 KHPESNKP--KPTTKKSKPIQADQDVIKALQRCR-----DEGIKRLDLSKSSITVIPSTVKECVH 184
            |.||....  :.|||:.        :|..|..||     :|.|..||.|..|:..:|   ||..:
Human    28 KRPEEELQCLEMTTKRK--------IIGRLVPCRCFRGEEEIISVLDYSHCSLQQVP---KEVFN 81

  Fly   185 ----LTELYLYSNKIGQLPPEIGCLVSLRNLALNENSLTSLPESLQNCSQLKVLDLRHNKLAEIP 245
                |.||||.:|:|.:||.::....:||.|::.:|.|::||.::.:...||.||:..|.:.|.|
Human    82 FERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFP 146

  Fly   246 PVIYRLRSLTTLYLRFNRITAVADDLRQLVNLTMLSLRENKIRELGSAIGALVNLTTLDVSHNHL 310
            ..|...:.||.:....|.|:.:.|...||:|||.|.|.:..:..|.:..|.||.|..|::..|||
Human   147 ENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHL 211

  Fly   311 EHLPEDIGNCVNLSALDLQHNELLDIPDSIGNLKSLVRLGMRYNRLSSVPATLKNCKSMDEFNVE 375
            :.||:.:.....|..|||.:||..::|:.:..:::|..|.|..|.|..:|
Human   212 KTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLP--------------- 261

  Fly   376 GNGITQLPDGMLASLSGLTTITLSRNQFASYPTGGPAQFTNVYSINLEHNRIDKIPYGIFSRAKG 440
                                                                     |...:.|.
Human   262 ---------------------------------------------------------GSIGKLKM 269

  Fly   441 LTKLNMKENMLTALPLDIGTWVNMVELNLATNALQKLPDDIMNLQNLEILILSNNMLKKIPNTIG 505
            |..|:|.:|.:..:.:||.....:.:|.|::|.||:|||.|..|:.|..|.:.:|.|..:|||||
Human   270 LVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIG 334

  Fly   506 NLRKLRILDLEENRIEVLPHEIGLLHELQRLILQTNQITMLPRSIGHLGNLTHLSVSENNLQFLP 570
            ||..|...|...|.:|.||..||.||.|:.|.:..|.:..|||.||...|:|.:|:..|.|:|||
Human   335 NLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLP 399

  Fly   571 EEIGSLESLENLYINQNPGLEKLPFELALCQNLKYLNI-DKCPLSTIPPEIQA 622
            ||||.::.|..|.::.| .|:.|||.....:.|..|.: |....:.||.:.:|
Human   400 EEIGQMQKLRVLNLSDN-RLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEA 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sur-8	NP_001262665.1	leucine-rich repeat	163..184	CDD:275380	7/20 (35%)
		leucine-rich repeat	185..207	CDD:275380	9/21 (43%)
		LRR_RI	204..401	CDD:238064	51/196 (26%)
		LRR_8	207..264	CDD:290566	18/56 (32%)
		leucine-rich repeat	208..230	CDD:275380	7/21 (33%)
		leucine-rich repeat	231..253	CDD:275380	8/21 (38%)
		LRR_8	252..310	CDD:290566	19/57 (33%)
		leucine-rich repeat	254..276	CDD:275380	7/21 (33%)
		leucine-rich repeat	277..299	CDD:275380	7/21 (33%)
		LRR_8	299..356	CDD:290566	18/56 (32%)
		leucine-rich repeat	300..322	CDD:275380	7/21 (33%)
		leucine-rich repeat	323..345	CDD:275380	7/21 (33%)
		LRR_8	344..403	CDD:290566	6/58 (10%)
		leucine-rich repeat	346..368	CDD:275380	6/21 (29%)
		leucine-rich repeat	369..392	CDD:275380	0/22 (0%)
		LRR_RI	<379..566	CDD:238064	51/186 (27%)
		leucine-rich repeat	417..440	CDD:275380	1/22 (5%)
		leucine-rich repeat	441..486	CDD:275380	16/44 (36%)
		LRR_8	463..520	CDD:290566	24/56 (43%)
		leucine-rich repeat	487..507	CDD:275380	9/19 (47%)
		leucine-rich repeat	510..532	CDD:275380	9/21 (43%)
		LRR_8	532..588	CDD:290566	22/55 (40%)
		leucine-rich repeat	556..578	CDD:275380	11/21 (52%)
		leucine-rich repeat	603..626	CDD:275380	6/21 (29%)
LRRC7	NP_001357714.1	leucine-rich repeat	64..85	CDD:275380	7/23 (30%)
		LRR_8	85..140	CDD:338972	20/54 (37%)
		leucine-rich repeat	86..108	CDD:275380	9/21 (43%)
		leucine-rich repeat	109..131	CDD:275380	7/21 (33%)
		LRR	130..440	CDD:227223	113/382 (30%)
		leucine-rich repeat	132..177	CDD:275380	15/44 (34%)
		leucine-rich repeat	178..200	CDD:275380	7/21 (33%)
		leucine-rich repeat	201..223	CDD:275380	7/21 (33%)
		leucine-rich repeat	224..246	CDD:275380	7/21 (33%)
		leucine-rich repeat	247..269	CDD:275380	7/93 (8%)
		leucine-rich repeat	270..292	CDD:275380	6/21 (29%)
		leucine-rich repeat	316..336	CDD:275380	9/19 (47%)
		leucine-rich repeat	339..361	CDD:275380	9/21 (43%)
		leucine-rich repeat	362..384	CDD:275380	8/21 (38%)
		leucine-rich repeat	385..407	CDD:275380	11/21 (52%)
		leucine-rich repeat	408..430	CDD:275380	7/22 (32%)
		PDZ_signaling	1485..1570	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910