Protein Alignment Sur-8 and lrrc8ab

DIOPT Version :10

• Sequence 1: NP_001262665.1
• Gene: Sur-8 / 42093
• FlyBaseID: FBgn0038504
• Length: 694
• Species: Drosophila melanogaster
• Sequence 2: XP_686175.1
• Gene: lrrc8ab / 557928
• ZFINID: ZDB-GENE-060531-43
• Length: 796
• Species: Danio rerio
• Alignment Length: 516
• Identity: 141/516 - (27%)
• Similarity: 227/516 - (43%)
• Gaps: 73/516 - (14%)

  Fly   152 KALQRCRDEGIKRLDLSKSSITVIPSTVKE---CVHLTELY--LYSNKIGQLPPEIGCLVSLRNL 211
            ::|::...|.|:    .:||.:.||....:   .:|:.:.|  |||.:......|:. ...||.|
Zfish   332 RSLKKYSFESIR----EESSYSDIPDVKNDFAFMLHMIDQYDPLYSKRFAVFLSEVS-ENKLRQL 391

  Fly   212 AL-NENSLTSLPESLQNCSQLKVLDLRHNKLAEIPPVIYRLRSLTTLYLRFNRITAVADDLRQLV 275
            .| ||.:|..|.:.:...||.| |:|....|:.||..::.|..|..|.|.......:...:.||.
Zfish   392 NLNNEWTLEKLRQRITKNSQEK-LELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPIIAQLT 455

  Fly   276 NLTMLSLRENKIRELGSAIGAL-VNLTTLDVSHNHLEHLPEDIGNCVNLSALDLQHNELLD---- 335
            ||..:.|.....:....|:..| .||.:|.:....::.:|..|.:..|||.|.|..|...|
Zfish   456 NLREMWLYHTPAKIEAPALAFLRENLKSLHIKFTDIKEIPLWIYSLKNLSELHLTGNLSADNNRY 520

  Fly   336 -IPDSIGNLKSLVRLGMRYNRLSSVPATLKNC-KSMDEFNVEGNGITQLPDGMLASLSGLTTITL 398
             :.|.:..||.|..|.::.| |:.:|..:.:. ..:.:.::...| |:|.  :|.||.
Zfish   521 IVIDGLRELKRLKVLRLKSN-LTKLPQVVTDVGMHLQKLSINNEG-TKLM--VLNSLK------- 574

  Fly   399 SRNQFASYPTGGPAQFTNVYSINLEHNRIDKIPYGIFSRAKGLTKLNMKENMLTALP--LDIGTW 461
                          :..|:..:.|....:::||:.||| ...|.::::|:|.|..:.  :.....
Zfish   575 --------------KMVNLSELELVRCDLERIPHSIFS-LHNLQEIDLKDNNLKTIEEIISFQHL 624

  Fly   462 VNMVELNLATNALQKLPDDIMNLQNLEILILSNNMLKKIPNTIGNLRKLRILDLEENRIEVLPHE 526
            ..:|.|.|..|.:..:|..|..|.|||.|.|:.|.::|:|:.:...||:|.|||..|.:..:|.|
Zfish   625 HRLVCLKLWYNQIAYIPIQIGTLVNLERLYLNRNKIEKMPHQLFFCRKMRFLDLSHNNLTDIPSE 689

  Fly   527 IGLLHELQRLILQTNQITMLPRSIGHLGNLTHLSVSENNLQFLPEEIGSLESLENLYINQNPGLE 591
            ||.|..||.|.:..|:|..||..:.....|..|::..|.||.||...|.|.||..|.:..| .||
Zfish   690 IGTLQNLQYLAVTANRIESLPPELFQCKKLRTLNLGNNCLQSLPSRFGELTSLTQLELRGN-RLE 753

  Fly   592 KLPFELALCQNLKY--LNIDKCPLSTIPPEIQAGGPSLVLQWLKMHSPYRQMXDVDGVWRT 650
            .||.||..|:.||.  |.::....:|:|||::                       :.:|||
Zfish   754 CLPVELGECRLLKRSGLIVEDSIFNTLPPEVK-----------------------EQLWRT 791

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur-8	NP_001262665.1	leucine-rich repeat	163..184	CDD:275380	4/23 (17%)
		LRR	185..535	CDD:443914	97/361 (27%)
		leucine-rich repeat	185..207	CDD:275380	5/23 (22%)
		leucine-rich repeat	208..230	CDD:275380	8/22 (36%)
		leucine-rich repeat	231..253	CDD:275380	7/21 (33%)
		leucine-rich repeat	254..276	CDD:275380	5/21 (24%)
		leucine-rich repeat	277..299	CDD:275380	4/22 (18%)
		leucine-rich repeat	300..322	CDD:275380	4/21 (19%)
		leucine-rich repeat	323..345	CDD:275380	8/26 (31%)
		leucine-rich repeat	346..368	CDD:275380	5/22 (23%)
		leucine-rich repeat	369..392	CDD:275380	6/22 (27%)
		leucine-rich repeat	417..440	CDD:275380	6/22 (27%)
		leucine-rich repeat	441..486	CDD:275380	11/46 (24%)
		PPP1R42	472..617	CDD:455733	55/146 (38%)
		leucine-rich repeat	487..507	CDD:275380	7/19 (37%)
		leucine-rich repeat	510..532	CDD:275380	10/21 (48%)
		leucine-rich repeat	556..578	CDD:275380	9/21 (43%)
		leucine-rich repeat	603..626	CDD:275380	7/24 (29%)
lrrc8ab	XP_686175.1	Pannexin_like	1..326	CDD:463622
		leucine-rich repeat	434..456	CDD:275380	5/21 (24%)
		leucine-rich repeat	457..480	CDD:275380	4/22 (18%)
		LRR	477..>758	CDD:443914	89/307 (29%)
		leucine-rich repeat	481..503	CDD:275380	4/21 (19%)
		leucine-rich repeat	504..531	CDD:275380	8/26 (31%)
		leucine-rich repeat	579..601	CDD:275380	6/22 (27%)
		leucine-rich repeat	602..626	CDD:275380	4/23 (17%)
		leucine-rich repeat	627..649	CDD:275380	7/21 (33%)
		leucine-rich repeat	650..672	CDD:275380	7/21 (33%)
		leucine-rich repeat	673..695	CDD:275380	10/21 (48%)
		leucine-rich repeat	696..718	CDD:275380	7/21 (33%)
		leucine-rich repeat	719..741	CDD:275380	9/21 (43%)
		leucine-rich repeat	742..762	CDD:275380	9/20 (45%)