DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sur-8 and LRRC8D

DIOPT Version :10

Sequence 1:NP_001262665.1 Gene:Sur-8 / 42093 FlyBaseID:FBgn0038504 Length:694 Species:Drosophila melanogaster
Sequence 2:NP_060573.2 Gene:LRRC8D / 55144 HGNCID:16992 Length:858 Species:Homo sapiens


Alignment Length:492 Identity:121/492 - (24%)
Similarity:225/492 - (45%) Gaps:67/492 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   153 ALQRCRDEGIKRLDLSKSSITVIPSTVKE---CVHLTELY--LYSNKIGQLPPEIGCLVSLRNLA 212
            :.::.|:|         ||.:.||....:   .:|:.:.|  |||.:.|....|:. ...||.::
Human   396 SFEKVREE---------SSFSDIPDVKNDFAFLLHMVDQYDQLYSKRFGVFLSEVS-ENKLREIS 450

  Fly   213 LN-ENSLTSLPESLQNCSQLKVLDLRHNKLAEIPPVIYRLRSLTTLYLRFNRITAVADDLRQLVN 276
            || |.:...|.:.:...:|.| .:|....|:.:|..::.|..|..|.|.......:...:.|:.|
Human   451 LNHEWTFEKLRQHISRNAQDK-QELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTN 514

  Fly   277 LTMLSLRENKIRELGSAIGALVNLTTLDVSHNHLEHLPEDIGNCV------NLSALDLQHNELLD 335
            |..|                            ||.|.|..:....      :|..|.::..::.:
Human   515 LQEL----------------------------HLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAE 551

  Fly   336 IPD---SIGNLKSLVRLG---MRYNRLSSVPATLKNCKSMDEFNVEGNGITQLPDGMLASLSGLT 394
            ||.   .:.||:.|..:|   ...|::..: .:|:..:.:...:|:.| :|::|..:......||
Human   552 IPAWVYLLKNLRELYLIGNLNSENNKMIGL-ESLRELRHLKILHVKSN-LTKVPSNITDVAPHLT 614

  Fly   395 TITLSRNQFASYPTGGPAQFTNVYSINLEHNRIDKIPYGIFSRAKGLTKLNMKENMLTALPLDIG 459
            .:.:..:...........:..||..:.|::..:::||:.||| ...|.:|::|.|.:..:. :|.
Human   615 KLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFS-LSNLQELDLKSNNIRTIE-EII 677

  Fly   460 TWVNMVE---LNLATNALQKLPDDIMNLQNLEILILSNNMLKKIPNTIGNLRKLRILDLEENRIE 521
            ::.::..   |.|..|.:..:|..|.:::|||.|..|||.|:.:|..:.:|:|||.||:..|.|.
Human   678 SFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNIS 742

  Fly   522 VLPHEIGLLHELQRLILQTNQITMLPRSIGHLGNLTHLSVSENNLQFLPEEIGSLESLENLYINQ 586
            ::|.|||||..||.|.:..|::.:||:.:.....|..|::.:|.:..|||::|.|..|..|.:..
Human   743 MIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKG 807

  Fly   587 NPGLEKLPFELALCQNLKY--LNIDKCPLSTIPPEIQ 621
            | .|::||.:|..|:.||.  |.::.....|:|.|::
Human   808 N-CLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVK 843

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sur-8NP_001262665.1 leucine-rich repeat 163..184 CDD:275380 4/23 (17%)
LRR 185..535 CDD:443914 87/367 (24%)
leucine-rich repeat 185..207 CDD:275380 6/23 (26%)
leucine-rich repeat 208..230 CDD:275380 6/22 (27%)
leucine-rich repeat 231..253 CDD:275380 5/21 (24%)
leucine-rich repeat 254..276 CDD:275380 4/21 (19%)
leucine-rich repeat 277..299 CDD:275380 2/21 (10%)
leucine-rich repeat 300..322 CDD:275380 4/27 (15%)
leucine-rich repeat 323..345 CDD:275380 6/24 (25%)
leucine-rich repeat 346..368 CDD:275380 4/24 (17%)
leucine-rich repeat 369..392 CDD:275380 4/22 (18%)
leucine-rich repeat 417..440 CDD:275380 7/22 (32%)
leucine-rich repeat 441..486 CDD:275380 10/47 (21%)
PPP1R42 472..617 CDD:455733 52/146 (36%)
leucine-rich repeat 487..507 CDD:275380 8/19 (42%)
leucine-rich repeat 510..532 CDD:275380 12/21 (57%)
leucine-rich repeat 556..578 CDD:275380 8/21 (38%)
leucine-rich repeat 603..626 CDD:275380 6/21 (29%)
LRRC8DNP_060573.2 Pannexin_like 1..384 CDD:463622
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 221..251
LRR 1 514..534 7/47 (15%)
leucine-rich repeat 515..536 CDD:275378 6/48 (13%)
LRR 2 538..559 4/20 (20%)
LRR 558..>851 CDD:443914 81/291 (28%)
LRR 3 561..582 5/21 (24%)
leucine-rich repeat 562..589 CDD:275380 5/27 (19%)
LRR 4 589..609 4/20 (20%)
leucine-rich repeat 590..615 CDD:275380 5/25 (20%)
LRR 5 612..632 2/19 (11%)
LRR 6 636..657 8/21 (38%)
leucine-rich repeat 637..659 CDD:275380 7/22 (32%)
LRR 7 659..680 5/21 (24%)
leucine-rich repeat 660..684 CDD:275380 5/24 (21%)
LRR 8 684..705 5/20 (25%)
leucine-rich repeat 685..707 CDD:275380 5/21 (24%)
LRR 9 707..728 9/20 (45%)
leucine-rich repeat 708..730 CDD:275380 9/21 (43%)
LRR 10 730..751 11/20 (55%)
leucine-rich repeat 731..753 CDD:275380 12/21 (57%)
LRR 11 753..774 6/20 (30%)
leucine-rich repeat 754..776 CDD:275380 6/21 (29%)
LRR 12 776..797 7/20 (35%)
leucine-rich repeat 777..799 CDD:275380 8/21 (38%)
LRR 13 799..820 7/21 (33%)
leucine-rich repeat 800..820 CDD:275380 7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

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