Protein Alignment Sur-8 and Mfhas1

DIOPT Version :10

• Sequence 1: NP_001262665.1
• Gene: Sur-8 / 42093
• FlyBaseID: FBgn0038504
• Length: 694
• Species: Drosophila melanogaster
• Sequence 2: NP_001074748.1
• Gene: Mfhas1 / 52065
• MGIID: 1098644
• Length: 1048
• Species: Mus musculus
• Alignment Length: 382
• Identity: 122/382 - (31%)
• Similarity: 179/382 - (46%)
• Gaps: 61/382 - (15%)

  Fly   198 LPPEIGCLVSLRNLALNENSLTSLPESLQNC-SQLKVLDLRHNKLAEIPPVIYRL-RSLTTLYLR 260
            ||..||   .:..|.|..|.|..:||.|.:. ..|:||.||.|:.|.:||.:..| ..||.|.:.
Mouse    54 LPANIG---DIEVLNLGNNGLEDVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVS 115

  Fly   261 FNRITAV-ADDLRQLVNLTMLSLRENKIRELGSAIGALVNLTTLDVSHNHLEHLPEDIGNCVN-L 323
            .||:|.: |:.:..|..|..|:|..|::..|.:.:|||.:|..||||.|.|.|||:.. :|:| |
Mouse   116 HNRLTILGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSF-SCLNHL 179

  Fly   324 SALDLQHNELLDIPDSIGNLKSLVRLGMRYNRLSSVPATLKNCKSMDEFNVEGNGITQLPDGM-- 386
            ..||:.||:|...|..:..|.:|..|.:..|||..:|..:...:::....:.|..:..||.|.
Mouse   180 RTLDVDHNQLTAFPQQLLQLAALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPRGFCE 244

  Fly   387 LASLSGLTTITLSRNQFASYPTGGPAQFTNVYSINLEHNRIDKIPYGIFSRAKGLTKLNMKENML 451
            ||||.                           |:.|::|.:..:| ..|||   |.:|.|
Mouse   245 LASLE---------------------------SLMLDNNGLQALP-DEFSR---LQRLKM----- 273

  Fly   452 TALPLDIGTWVNMVELNLATNALQKLPDDIMNLQNLEILILSNNMLKKIPNTIGNLRKLRILDLE 516
                           |||::|..::.|..::.|..||.|.||.|.|..:|:.|..|.:|..|.|:
Mouse   274 ---------------LNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLIAGLGRLLTLWLD 323

  Fly   517 ENRIEVLPHEIGLLHELQRLILQTNQITMLPRSIGHLGNLTHLSVSENNLQFLPEEI 573
            .|||..||..|..|..|:.|:||.|||.:||.:.|.|..:....:.:|.|...|.|:
Mouse   324 NNRIRYLPDSIVELTGLEELVLQGNQIAVLPDNFGQLSRVGLWKIKDNPLIQPPYEV 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur-8	NP_001262665.1	leucine-rich repeat	163..184	CDD:275380
		LRR	185..535	CDD:443914	108/342 (32%)
		leucine-rich repeat	185..207	CDD:275380	4/8 (50%)
		leucine-rich repeat	208..230	CDD:275380	7/22 (32%)
		leucine-rich repeat	231..253	CDD:275380	10/22 (45%)
		leucine-rich repeat	254..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..299	CDD:275380	8/21 (38%)
		leucine-rich repeat	300..322	CDD:275380	11/21 (52%)
		leucine-rich repeat	323..345	CDD:275380	8/21 (38%)
		leucine-rich repeat	346..368	CDD:275380	6/21 (29%)
		leucine-rich repeat	369..392	CDD:275380	8/24 (33%)
		leucine-rich repeat	417..440	CDD:275380	7/22 (32%)
		leucine-rich repeat	441..486	CDD:275380	9/44 (20%)
		PPP1R42	472..617	CDD:455733	38/102 (37%)
		leucine-rich repeat	487..507	CDD:275380	9/19 (47%)
		leucine-rich repeat	510..532	CDD:275380	10/21 (48%)
		leucine-rich repeat	556..578	CDD:275380	4/18 (22%)
		leucine-rich repeat	603..626	CDD:275380
Mfhas1	NP_001074748.1	PLN03150	<23..179	CDD:178695	49/128 (38%)
		Required for interaction with PPP2R2A. /evidence=ECO:0000250|UniProtKB:Q9Y4C4	60..645		118/373 (32%)
		Required for interaction with PJA2. /evidence=ECO:0000250|UniProtKB:Q9Y4C4	60..360		113/351 (32%)
		leucine-rich repeat	61..84	CDD:275380	7/22 (32%)
		leucine-rich repeat	85..108	CDD:275380	10/22 (45%)
		LRR	<109..>371	CDD:443914	97/313 (31%)
		leucine-rich repeat	109..132	CDD:275380	8/22 (36%)
		leucine-rich repeat	133..155	CDD:275380	8/21 (38%)
		leucine-rich repeat	156..178	CDD:275380	11/22 (50%)
		leucine-rich repeat	179..224	CDD:275380	14/44 (32%)
		leucine-rich repeat	225..247	CDD:275380	5/21 (24%)
		leucine-rich repeat	248..270	CDD:275380	9/52 (17%)
		leucine-rich repeat	271..293	CDD:275380	8/41 (20%)
		leucine-rich repeat	294..316	CDD:275380	10/21 (48%)
		leucine-rich repeat	317..339	CDD:275380	10/21 (48%)
		leucine-rich repeat	340..360	CDD:275380	10/19 (53%)
		P-loop containing Nucleoside Triphosphate Hydrolases	405..561	CDD:476819
		COR	656..902	CDD:406489