DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sur-8 and Phlpp2

DIOPT Version :9

Sequence 1:	NP_001262665.1	Gene:	Sur-8 / 42093	FlyBaseID:	FBgn0038504	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_001102601.2	Gene:	Phlpp2 / 498949	RGDID:	1562857	Length:	1359	Species:	Rattus norvegicus

Alignment Length:	692	Identity:	177/692 - (25%)
Similarity:	279/692 - (40%)	Gaps:	143/692 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 GSGTAGAIAGTEELSNANSPANGAGG-----ATGSTGSGQQPTGSNGHS---HLHNENNANMPPE 118
            |:.|..|...|...|:::|.::.:..     .|..|.:.:...|....|   .||.:....:.|.
  Rat    72 GADTTTATTTTTSSSSSSSSSSSSSDLHLVLCTVETPASEICAGEGRESLYLQLHGDLVRRLEPT 136

  Fly   119 TRPKMVTVKH-------------PESNKPKPTTK----KSKPIQADQDVIKALQRCRDEGIKRLD 166
            .||..:...:             .|:..|..:..    ..||.|.|.     |.|....||..:.
  Rat   137 ERPLQIVYDYLSRLGFEDPVRIQEEATNPDLSCMIRFYGEKPCQMDH-----LDRILLSGIYNVR 196

  Fly   167 LSKSSI-------------TVIPSTVKEC----VHLTELYLYSNKIGQLPPEIGCL--------- 205
            ..|:.:             .:|.|:||:|    :|:  |.|...||.::......|
  Rat   197 KGKTQLHKWAERLVVLCGTCLIVSSVKDCQTGKMHI--LPLVGGKIEEVKRRQHSLAFSSAGAQA 259

  Fly   206 ----VSLRNLA---------------------LNENSLTSLPESLQNCSQLKVLDLRHNKLAEIP 245
                ||...||                     |:..||..:||.|.....:..|:||||.:....
  Rat   260 QTYHVSFETLAEYQRWQRQASKVVSQRISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLER 324

  Fly   246 P----VIYRLRSLTTLYLRFNRITAVADDLRQLVNLTMLSLRENKIRELGSAIGALVNLTTLDVS 306
            |    .:|:...|..|.|..|::......|.::..||.|:|..|...:|.|.||.|:||.||.:.
  Rat   325 PGGLDTLYKFSQLKGLNLSHNKLGLFPVLLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLD 389

  Fly   307 HNHLEHLPEDIGNCVNLSALDLQHNELLDIPDSI------------GNLKSLVRLGM--RYNRLS 357
            .|.|..||:::||...|::|.:..|....||:.:            ||...::.||:  |.|.:.
  Rat   390 GNVLTALPDELGNLQQLTSLGISFNNFSQIPEVLEKLTMLDKVVMAGNRLEILNLGVLTRMNHVK 454

  Fly   358 SVPATLKNCKSMDEFNVEGN-GIT-------QLPDGMLASLSGLTTITLSRNQFAS--------- 405
            .|...:.:.|::...|:||| .||       ||.|..|:||..|..:...|||...
  Rat   455 HVDLRMNHLKTVIIENLEGNKHITHMDLRDNQLTDLDLSSLCSLEQLHCERNQLRELTLSGFSLR 519

  Fly   406 --YPTGGPAQFTNVY-------SINLEHNRIDKIPYGIFSRAKGLTKLNMKENMLTALPLDIGTW 461
              |.........|||       |:.|..|.::.|| .....||.|..|::..|:||.:|:.|.:.
  Rat   520 NLYANWNKLTAVNVYPVPSLLTSLELSRNLLECIP-DWACEAKKLEILDISYNLLTEVPMRILSS 583

  Fly   462 VNMVELNLATNALQKLPDDIMNLQNLEILILSNNMLKKIPNTI-GNLRKLRILDLEENRIEVLPH 525
            :::.:|.:..|.:..||..:.::. ||:|.:.:|.|.::|:|: .....||.|:...|.:|.||.
  Rat   584 LSLRKLMVGHNHIHVLPALVEHIP-LEVLDVQHNTLSRLPDTLFSKALNLRYLNASANSLESLPS 647

  Fly   526 EIG---LLHELQRLILQTNQIT--MLPRSIGHLGNLTHLSVSENNLQFLP-EEIGSLESLENLYI 584
            ...   .|..||.|.|..|.:|  .:|..:|| .:|..|.::.|.||..| .::..||.||.|.:
  Rat   648 ACAGEESLSVLQLLYLTNNLLTDQCIPVLVGH-PHLRVLHLANNQLQTFPASKLNKLEQLEELNL 711

  Fly   585 NQNPGLEKLPFELALCQNLKYLNIDKCPLSTIP-----PEIQ 621
            :.|. |:.:|..:|.|:.|..|......:|..|     |:||
  Rat   712 SGNK-LKAIPTTIANCKRLHTLVAHANNISIFPEILQLPQIQ 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sur-8	NP_001262665.1	leucine-rich repeat	163..184	CDD:275380	6/37 (16%)
		leucine-rich repeat	185..207	CDD:275380	5/34 (15%)
		LRR_RI	204..401	CDD:238064	69/256 (27%)
		LRR_8	207..264	CDD:290566	20/81 (25%)
		leucine-rich repeat	208..230	CDD:275380	8/42 (19%)
		leucine-rich repeat	231..253	CDD:275380	7/25 (28%)
		LRR_8	252..310	CDD:290566	20/57 (35%)
		leucine-rich repeat	254..276	CDD:275380	5/21 (24%)
		leucine-rich repeat	277..299	CDD:275380	10/21 (48%)
		LRR_8	299..356	CDD:290566	21/70 (30%)
		leucine-rich repeat	300..322	CDD:275380	9/21 (43%)
		leucine-rich repeat	323..345	CDD:275380	7/33 (21%)
		LRR_8	344..403	CDD:290566	21/68 (31%)
		leucine-rich repeat	346..368	CDD:275380	5/23 (22%)
		leucine-rich repeat	369..392	CDD:275380	12/30 (40%)
		LRR_RI	<379..566	CDD:238064	61/217 (28%)
		leucine-rich repeat	417..440	CDD:275380	8/29 (28%)
		leucine-rich repeat	441..486	CDD:275380	11/44 (25%)
		LRR_8	463..520	CDD:290566	15/57 (26%)
		leucine-rich repeat	487..507	CDD:275380	7/20 (35%)
		leucine-rich repeat	510..532	CDD:275380	8/24 (33%)
		LRR_8	532..588	CDD:290566	20/58 (34%)
		leucine-rich repeat	556..578	CDD:275380	7/22 (32%)
		leucine-rich repeat	603..626	CDD:275380	7/24 (29%)
Phlpp2	NP_001102601.2	RA_PHLPP2	66..178	CDD:340761	17/105 (16%)
		PH_PHLPP-like	185..279	CDD:270131	19/95 (20%)
		PLN00113	284..>762	CDD:215061	136/473 (29%)
		leucine-rich repeat	289..309	CDD:275380	6/19 (32%)
		leucine-rich repeat	310..336	CDD:275380	7/25 (28%)
		leucine-rich repeat	337..359	CDD:275380	5/21 (24%)
		leucine-rich repeat	360..382	CDD:275380	10/21 (48%)
		leucine-rich repeat	383..405	CDD:275380	9/21 (43%)
		leucine-rich repeat	406..428	CDD:275380	5/21 (24%)
		leucine-rich repeat	429..452	CDD:275380	5/22 (23%)
		leucine-rich repeat	453..476	CDD:275380	6/22 (27%)
		leucine-rich repeat	477..497	CDD:275380	8/19 (42%)
		leucine-rich repeat	498..517	CDD:275380	4/18 (22%)
		leucine-rich repeat	518..539	CDD:275380	4/20 (20%)
		leucine-rich repeat	540..562	CDD:275380	6/22 (27%)
		leucine-rich repeat	563..584	CDD:275380	7/20 (35%)
		leucine-rich repeat	586..607	CDD:275380	4/20 (20%)
		leucine-rich repeat	608..631	CDD:275380	7/22 (32%)
		leucine-rich repeat	632..681	CDD:275380	17/49 (35%)
		leucine-rich repeat	682..705	CDD:275380	7/22 (32%)
		leucine-rich repeat	706..728	CDD:275380	8/22 (36%)
		leucine-rich repeat	751..772	CDD:275380	2/2 (100%)
		PP2Cc	820..1069	CDD:238083
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10213
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910