DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sur-8 and lrrc8da

DIOPT Version :9

Sequence 1:NP_001262665.1 Gene:Sur-8 / 42093 FlyBaseID:FBgn0038504 Length:694 Species:Drosophila melanogaster
Sequence 2:XP_002660860.1 Gene:lrrc8da / 497399 ZFINID:ZDB-GENE-061009-26 Length:825 Species:Danio rerio


Alignment Length:652 Identity:142/652 - (21%)
Similarity:259/652 - (39%) Gaps:155/652 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    91 STGSGQQPT-GSNGHSHLHNENNANMP-PET-------------RPKMVTVKHPESNKPKPTTKK 140
            |.|:.|:.| ||..|.|:.:|::.:.| .||             .|.:.|:...:..:.|...:|
Zfish   202 SEGNKQRFTGGSVYHKHVSSEDSQSTPLVETPTAPFSTEKLIAEAPSLTTLDKKDGEQAKALFEK 266

  Fly   141 SKPIQAD-------------QDVIKALQ-------------------RCRDE------------- 160
            .:..:|.             |..||||:                   .|:.:             
Zfish   267 VRKFRAHVEDSDFIYKLYVAQTAIKALKVILILSYTSTFAAEISFCHICKPKVESLTGYDQFFCT 331

  Fly   161 -----------------------------------GIKRLDLSK----SSITVIPSTVKE---CV 183
                                               .:|.....|    ||.:.||....:   .:
Zfish   332 HNMAFMLRKLLFTFMAMICLYGLVCLYTLYWLFRRPLKEYSFEKVREESSFSDIPDVKNDFAFLL 396

  Fly   184 HLTELY--LYSNKIGQLPPEIGCLVSLRNLALN-ENSLTSLPESLQNCSQLKVLDLRHNKLAEIP 245
            |:.:.|  |||.:.|....|:. ...||.::|| |.:...|.:.:...:| :..:|....|:.:|
Zfish   397 HMVDQYDQLYSKRFGVFLSEVS-ENKLREISLNHEWTFEKLRQHVSTNAQ-EEQELHLFMLSGLP 459

  Fly   246 PVIYRLRSLTTLYLRFNRITAVADDLRQLVNLTMLSLRENKIRELGSAIGALVNLTTLDVSHNHL 310
            ..::.|..|..|.|.......::..:.|:.||          |||                  ||
Zfish   460 NAVFDLTDLEILKLELIPEVRISAKVSQMTNL----------REL------------------HL 496

  Fly   311 EHLPEDIGNCV------NLSALDLQHNELLDIPDSIGNLKSLVRLGM------RYNRLSSVPATL 363
            .|.|..:....      :|..|.::..::.:||..|..|:||..|.:      .:|::..: .:|
Zfish   497 YHCPAKVEQTAFTFLRDHLRCLHIKFTDVAEIPPWIYLLRSLKELNLFGNLNSEHNKMIGL-ESL 560

  Fly   364 KNCKSMDEFNVEGNGITQLPDGMLASLSGLTTITLSRNQFASYPTGGPAQFTNVYSINLEHNRID 428
            ::.:.:....::.| :.::|..:......|..:.:..:...........:.|::..:.|.:..::
Zfish   561 RDLRHLRTLYLKSN-LNKIPSNLTDLSPHLVKLVIHNDGTKLLVMNSLKKMTSLVDLELHNCDLE 624

  Fly   429 KIPYGIFSRAKGLTKLNMKENMLTALP--LDIGTWVNMVELNLATNALQKLPDDIMNLQNLEILI 491
            :||:.|||.| .|.:|::|.|.:..:.  :.......:|.|.|..|.:..:|..|..:::||.||
Zfish   625 RIPHSIFSLA-NLQELDLKNNNIRTIEEIISFQHLRRLVCLKLWYNKISIIPPSIGLVKSLESLI 688

  Fly   492 LSNNMLKKIPNTIGNLRKLRILDLEENRIEVLPHEIGLLHELQRLILQTNQITMLPRSIGHLGNL 556
            :.:|.::.:|.::.:|.|||.:||..|.|..:|.||||||.||...:..|::.:||..:.....|
Zfish   689 ICHNKVENLPPSLFHLPKLRHIDLSNNSISNIPVEIGLLHNLQHFAITGNKVEVLPSQLFKCSKL 753

  Fly   557 THLSVSENNLQFLPEEIGSLESLENLYINQNPGLEKLPFELALCQNLK--YLNIDKCPLSTIPPE 619
            ..|.|..||:..:|:.||.|..|.:|.:..| .|:.|||:|..||.|:  .|.::.....|:|.|
Zfish   754 KVLCVGHNNITSIPDSIGQLVQLSHLELKGN-CLDCLPFQLGQCQLLRKNLLFVEDHLFDTLPIE 817

  Fly   620 IQ 621
            ::
Zfish   818 VK 819

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sur-8NP_001262665.1 leucine-rich repeat 163..184 CDD:275380 6/27 (22%)
leucine-rich repeat 185..207 CDD:275380 6/23 (26%)
LRR_RI 204..401 CDD:238064 38/209 (18%)
LRR_8 207..264 CDD:290566 14/57 (25%)
leucine-rich repeat 208..230 CDD:275380 6/22 (27%)
leucine-rich repeat 231..253 CDD:275380 4/21 (19%)
LRR_8 252..310 CDD:290566 9/57 (16%)
leucine-rich repeat 254..276 CDD:275380 4/21 (19%)
leucine-rich repeat 277..299 CDD:275380 4/21 (19%)
LRR_8 299..356 CDD:290566 14/68 (21%)
leucine-rich repeat 300..322 CDD:275380 4/27 (15%)
leucine-rich repeat 323..345 CDD:275380 6/21 (29%)
LRR_8 344..403 CDD:290566 8/64 (13%)
leucine-rich repeat 346..368 CDD:275380 4/27 (15%)
leucine-rich repeat 369..392 CDD:275380 2/22 (9%)
LRR_RI <379..566 CDD:238064 50/188 (27%)
leucine-rich repeat 417..440 CDD:275380 7/22 (32%)
leucine-rich repeat 441..486 CDD:275380 10/46 (22%)
LRR_8 463..520 CDD:290566 19/56 (34%)
leucine-rich repeat 487..507 CDD:275380 6/19 (32%)
leucine-rich repeat 510..532 CDD:275380 12/21 (57%)
LRR_8 532..588 CDD:290566 16/55 (29%)
leucine-rich repeat 556..578 CDD:275380 9/21 (43%)
leucine-rich repeat 603..626 CDD:275380 5/21 (24%)
lrrc8daXP_002660860.1 Pannexin_like 1..360 CDD:289311 23/157 (15%)
leucine-rich repeat 491..533 CDD:275380 12/69 (17%)
LRR_RI <538..786 CDD:238064 63/251 (25%)
leucine-rich repeat 538..565 CDD:275380 4/27 (15%)
leucine-rich repeat 566..612 CDD:275380 3/46 (7%)
LRR_8 611..671 CDD:290566 16/60 (27%)
leucine-rich repeat 613..635 CDD:275380 7/22 (32%)
leucine-rich repeat 636..660 CDD:275380 4/23 (17%)
leucine-rich repeat 661..683 CDD:275380 6/21 (29%)
LRR_8 682..740 CDD:290566 24/57 (42%)
leucine-rich repeat 684..706 CDD:275380 7/21 (33%)
leucine-rich repeat 707..729 CDD:275380 12/21 (57%)
LRR_8 729..784 CDD:290566 16/54 (30%)
leucine-rich repeat 730..752 CDD:275380 5/21 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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