Protein Alignment Sur-8 and lrrc8e

DIOPT Version :10

• Sequence 1: NP_001262665.1
• Gene: Sur-8 / 42093
• FlyBaseID: FBgn0038504
• Length: 694
• Species: Drosophila melanogaster
• Sequence 2: NP_001007863.1
• Gene: lrrc8e / 493249
• XenbaseID: XB-GENE-6041092
• Length: 806
• Species: Xenopus tropicalis
• Alignment Length: 554
• Identity: 137/554 - (24%)
• Similarity: 219/554 - (39%)
• Gaps: 138/554 - (24%)

  Fly    92 TGSGQQPTGSNGHS---HLHNENNA----------NMPPETRPKMVTVKHPESNKPKPTTKKSKP 143
            ||.|..|...|..:   ||.::.::          :...|:|.:.:.:.|     ..|..|..:.
 Frog   361 TGIGDIPDVKNDFAFVLHLVDQYDSLYSKRFAVFLSEVSESRLRQLNLNH-----EWPADKLRQK 420

  Fly   144 IQADQDVIKALQRCRDEGIKRLDLSKSSITVIPSTVKECVHLTELYLYSNKIGQLPPEIGCLVSL 208
            :|.           ..||  ||:|....:..:|.||.|...:..|.|.......:||.:..||.|
 Frog   421 LQH-----------TPEG--RLELHLFKLPGLPDTVFEVAEMESLKLEMVNEALIPPLVSKLVRL 472

  Fly   209 RNLALNENSLTSLPESLQNCS------QLKVLDLRHNKLAEIPPVIYRLRSLTTLYLRFNRITAV 267
            ..|     ||.:....:|:.|      .|::|.::.:.:.|||..|:.||:|..|:|
 Frog   473 EEL-----SLINCTAKVQHASLAYLRDHLRILQVKFDDIKEIPLWIFSLRALEELHL-------- 524

  Fly   268 ADDLRQLVNLTMLSLRENKIRELGSAIGALVNLTTLDVSHNHLEHLPEDIGNCVNLSALDLQHNE 332
                                      .|.|                           :.||..|.
 Frog   525 --------------------------FGWL---------------------------SQDLSKNP 536

  Fly   333 LLDIPDSIGNLKSLVRLGMRYNRLSSVPATLKNCKS-MDEFNVEGNGITQLPDGMLASLSGLTTI 396
            .|   :|:..||||..|.::.| ||.:|||:.:... :.:|::..:|.      .|.:|:.|..:
 Frog   537 AL---ESLRELKSLKVLTIKSN-LSKIPATVADVAGHLQKFSIHNDGT------KLLTLNALKRL 591

  Fly   397 TLSRNQFASYPTGGPAQFTNVYSINLEHNRIDKIPYGIFSRAKGLTKLNMKENMLTALP--LDIG 459
            .|                  |..:.|....:::||:.:|| ...|..|::|||.|..:.  :.:.
 Frog   592 AL------------------VKELELVRCELERIPHAVFS-LTNLQVLDLKENTLHTIEEIISLQ 637

  Fly   460 TWVNMVELNLATNALQKLPDDIMNLQNLEILILSNNMLKKIPNTIGNLRKLRILDLEENRIEVLP 524
            ....:..|.|..|.:..:|:.|..|:.||.|.|:.|.:..||:.:....|||.|||..|.|..||
 Frog   638 HCRKLSVLRLWHNQIAYIPEHIRKLKGLEELSLNRNKILVIPSQLFLCNKLRHLDLSNNEIRELP 702

  Fly   525 HEIGLLHELQRLILQTNQITMLPRSIGHLGNLTHLSVSENNLQFLPEEIGSLESLENLYINQNPG 589
            .|||:|..||.|.|..|.:..||..:.....|..|.:.:|.|..|..::|||..|..|.:..| .
 Frog   703 PEIGVLQLLQYLGLSGNFLEDLPNELFFCQKLKTLKLGQNRLGNLSPKVGSLVCLVKLELKGN-R 766

  Fly   590 LEKLPFELALCQNLKY--LNIDKCPLSTIPPEIQ 621
            ::.||.||..|.:||.  |.::.....|:|.|::
 Frog   767 MDTLPPELGNCVSLKRSGLTVEPSLFETLPVEVR 800

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur-8	NP_001262665.1	leucine-rich repeat	163..184	CDD:275380	7/20 (35%)
		LRR	185..535	CDD:443914	87/358 (24%)
		leucine-rich repeat	185..207	CDD:275380	5/21 (24%)
		leucine-rich repeat	208..230	CDD:275380	6/27 (22%)
		leucine-rich repeat	231..253	CDD:275380	7/21 (33%)
		leucine-rich repeat	254..276	CDD:275380	3/21 (14%)
		leucine-rich repeat	277..299	CDD:275380	2/21 (10%)
		leucine-rich repeat	300..322	CDD:275380	0/21 (0%)
		leucine-rich repeat	323..345	CDD:275380	6/21 (29%)
		leucine-rich repeat	346..368	CDD:275380	8/21 (38%)
		leucine-rich repeat	369..392	CDD:275380	4/22 (18%)
		leucine-rich repeat	417..440	CDD:275380	6/22 (27%)
		leucine-rich repeat	441..486	CDD:275380	12/46 (26%)
		PPP1R42	472..617	CDD:455733	52/146 (36%)
		leucine-rich repeat	487..507	CDD:275380	7/19 (37%)
		leucine-rich repeat	510..532	CDD:275380	13/21 (62%)
		leucine-rich repeat	556..578	CDD:275380	8/21 (38%)
		leucine-rich repeat	603..626	CDD:275380	6/21 (29%)
lrrc8e	NP_001007863.1	Pannexin_like	1..341	CDD:463622
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	72..103
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	182..213
		leucine-rich repeat	472..495	CDD:275380	6/27 (22%)
		leucine-rich repeat	496..518	CDD:275380	7/21 (33%)
		LRR	518..>782	CDD:443914	90/354 (25%)
		leucine-rich repeat	519..546	CDD:275380	11/90 (12%)
		LRR 1	544..566		11/22 (50%)
		leucine-rich repeat	547..569	CDD:275380	8/22 (36%)
		LRR 2	569..589		4/25 (16%)
		leucine-rich repeat	570..593	CDD:275380	5/28 (18%)
		LRR 3	593..614		7/39 (18%)
		leucine-rich repeat	594..616	CDD:275380	6/22 (27%)
		LRR 4	616..637		6/20 (30%)
		leucine-rich repeat	617..641	CDD:275380	6/23 (26%)
		LRR 5	641..662		5/20 (25%)
		leucine-rich repeat	642..664	CDD:275380	6/21 (29%)
		LRR 6	664..685		7/20 (35%)
		leucine-rich repeat	665..687	CDD:275380	7/21 (33%)
		LRR 7	687..708		13/20 (65%)
		leucine-rich repeat	688..710	CDD:275380	13/21 (62%)
		LRR 8	710..731		7/20 (35%)
		leucine-rich repeat	711..733	CDD:275380	7/21 (33%)
		LRR 9	733..754		6/20 (30%)
		leucine-rich repeat	734..756	CDD:275380	8/21 (38%)
		LRR 10	756..777		7/21 (33%)