DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sur-8 and scrib

DIOPT Version :9

Sequence 1:	NP_001262665.1	Gene:	Sur-8 / 42093	FlyBaseID:	FBgn0038504	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster

Alignment Length:	436	Identity:	133/436 - (30%)
Similarity:	210/436 - (48%)	Gaps:	51/436 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 IKRLDLSKSSITVIPSTV-KECVHLTELYLYSNKIGQLPPEIGCLVSLRNLALNENSLTSLPESL 225
            ::.:|....|:..:|..: :....|.||:|.:|.|..||.....|..||.|.|::|.:..||..:
  Fly    15 VEFVDKRHCSLPQVPEEILRYSRTLEELFLDANHIRDLPKNFFRLHRLRKLGLSDNEIGRLPPDI 79

  Fly   226 QNCSQLKVLDLRHNKLAEIPPVIYRLRSLTTLYLRFNRITAVADDLRQLVNLTMLSLRENKIREL 290
            ||...|..||:..|.:.:||..|..|:||.......|.|..:.....||.|||:|.|.:..:..|
  Fly    80 QNFENLVELDVSRNDIPDIPDDIKHLQSLQVADFSSNPIPKLPSGFSQLKNLTVLGLNDMSLTTL 144

  Fly   291 GSAIGALVNLTTLDVSHNHLEHLPEDIGNCVNLSALDLQHNELLDIPDSIGNLKSLVRLGMRYNR 355
            .:..|:|..|.:|::..|.|:||||.|.....|..|||..||:.|:|..:|.|..|..|.:.:|:
  Fly   145 PADFGSLTQLESLELRENLLKHLPETISQLTKLKRLDLGDNEIEDLPPYLGYLPGLHELWLDHNQ 209

  Fly   356 LSSVPATLKNCKSMDEFNVEGNGITQLPDGMLASLSGLTTITLSRNQFASYPTGGPAQFTNVYSI 420
            |..:|..|                     |:|..|:.|
  Fly   210 LQRLPPEL---------------------GLLTKLTYL--------------------------- 226

  Fly   421 NLEHNRIDKIPYGIFSRAKGLTKLNMKENMLTALPLDIGTWVNMVELNLATNALQKLPDDIMNLQ 485
            ::..||::::|..| |....||.|::.:|:|.|||..|.....:..|.|..|.||:|.|.:.|.:
  Fly   227 DVSENRLEELPNEI-SGLVSLTDLDLAQNLLEALPDGIAKLSRLTILKLDQNRLQRLNDTLGNCE 290

  Fly   486 NLEILILSNNMLKKIPNTIGNLRKLRILDLEENRIEVLPHEIGLLHELQRLILQTNQITMLPRSI 550
            |::.|||:.|.|.::|.:||.:.||..|:::.|.:|.||.|||....|..|.|:.|::..||..:
  Fly   291 NMQELILTENFLSELPASIGQMTKLNNLNVDRNALEYLPLEIGQCANLGVLSLRDNKLKKLPPEL 355

  Fly   551 GHLGNLTHLSVSENNLQFLPEEIGSLESLENLYINQNPGLEKLPFE 596
            |:...|..|.||.|.|.:||..:.:|: |:.:::::|.....|.|:
  Fly   356 GNCTVLHVLDVSGNQLLYLPYSLVNLQ-LKAVWLSENQSQPLLTFQ 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sur-8	NP_001262665.1	leucine-rich repeat	163..184	CDD:275380	3/21 (14%)
		leucine-rich repeat	185..207	CDD:275380	9/21 (43%)
		LRR_RI	204..401	CDD:238064	61/196 (31%)
		LRR_8	207..264	CDD:290566	20/56 (36%)
		leucine-rich repeat	208..230	CDD:275380	9/21 (43%)
		leucine-rich repeat	231..253	CDD:275380	8/21 (38%)
		LRR_8	252..310	CDD:290566	17/57 (30%)
		leucine-rich repeat	254..276	CDD:275380	5/21 (24%)
		leucine-rich repeat	277..299	CDD:275380	7/21 (33%)
		LRR_8	299..356	CDD:290566	22/56 (39%)
		leucine-rich repeat	300..322	CDD:275380	9/21 (43%)
		leucine-rich repeat	323..345	CDD:275380	10/21 (48%)
		LRR_8	344..403	CDD:290566	10/58 (17%)
		leucine-rich repeat	346..368	CDD:275380	6/21 (29%)
		leucine-rich repeat	369..392	CDD:275380	3/22 (14%)
		LRR_RI	<379..566	CDD:238064	57/186 (31%)
		leucine-rich repeat	417..440	CDD:275380	5/22 (23%)
		leucine-rich repeat	441..486	CDD:275380	17/44 (39%)
		LRR_8	463..520	CDD:290566	21/56 (38%)
		leucine-rich repeat	487..507	CDD:275380	8/19 (42%)
		leucine-rich repeat	510..532	CDD:275380	9/21 (43%)
		LRR_8	532..588	CDD:290566	17/55 (31%)
		leucine-rich repeat	556..578	CDD:275380	9/21 (43%)
		leucine-rich repeat	603..626	CDD:275380
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	91/316 (29%)
		leucine-rich repeat	18..38	CDD:275380	3/19 (16%)
		LRR_8	37..95	CDD:290566	22/57 (39%)
		leucine-rich repeat	39..61	CDD:275380	9/21 (43%)
		leucine-rich repeat	62..84	CDD:275380	9/21 (43%)
		LRR_8	84..138	CDD:290566	19/53 (36%)
		leucine-rich repeat	85..107	CDD:275380	8/21 (38%)
		leucine-rich repeat	108..130	CDD:275380	5/21 (24%)
		LRR_8	129..187	CDD:290566	22/57 (39%)
		leucine-rich repeat	131..153	CDD:275380	7/21 (33%)
		leucine-rich repeat	154..176	CDD:275380	9/21 (43%)
		leucine-rich repeat	177..199	CDD:275380	10/21 (48%)
		LRR_8	198..256	CDD:290566	19/106 (18%)
		leucine-rich repeat	200..222	CDD:275380	8/42 (19%)
		leucine-rich repeat	223..245	CDD:275380	7/49 (14%)
		LRR_8	267..325	CDD:290566	21/57 (37%)
		leucine-rich repeat	269..289	CDD:275380	7/19 (37%)
		leucine-rich repeat	292..314	CDD:275380	8/21 (38%)
		leucine-rich repeat	315..337	CDD:275380	9/21 (43%)
		LRR_4	337..375	CDD:289563	13/37 (35%)
		leucine-rich repeat	361..382	CDD:275380	8/20 (40%)
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46761
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.910