DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sur-8 and f-cup

DIOPT Version :9

Sequence 1:	NP_001262665.1	Gene:	Sur-8 / 42093	FlyBaseID:	FBgn0038504	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_001262544.1	Gene:	f-cup / 41677	FlyBaseID:	FBgn0028487	Length:	802	Species:	Drosophila melanogaster

Alignment Length:	684	Identity:	157/684 - (22%)
Similarity:	259/684 - (37%)	Gaps:	213/684 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 NGHSHLHNENNANMPPETRPKMVTVKHPESNKPKPTTKKSKPIQADQDVIKALQRCRDE-GIKRL 165
            :|..:|.|:..|.:|    .::..:...:::        ||.:..:|..||......:: .:..|
  Fly   109 SGTLNLSNKALARVP----KRLYDINEADAD--------SKAVNLEQLTIKEEDAWWNQVPLNNL 161

  Fly   166 DLSKSSITVIPSTVKECVHLTELYLYSNKIGQLPPEIGCLVSLRNLALNENSLTSLPESLQNCSQ 230
            |||.:::|.|...::....||.|.|:.|.:.:||||||.|..|..|.::.|.|:.||.::.:..:
  Fly   162 DLSSNTLTHISPKIENLQSLTVLTLHDNALVELPPEIGKLEKLVRLNVSHNKLSQLPRAMYSLPE 226

  Fly   231 LKVLDLRHNKLAEIPPVIYRLRSLTTLYLRFNRITAVADDLRQLVNLTMLSLRENKIRELGSAIG 295
            |:.|::.:|:..|:.|.|..|..|..|....|.|.::...:..||.||.|.|..|.|:||...:.
  Fly   227 LRHLNISYNEFVELNPDISDLHMLEFLDGGHNNIQSLPGGIGFLVRLTALLLPYNHIKELPPDLV 291

  Fly   296 ALVNLTTLDVSHNHLEHLPEDIGNCVNLSALDLQHNELLDIPDSIGN------------------ 342
            .:.:|..:|:.||.|..||||:|....|..|.||||::|::|:..||
  Fly   292 NMRSLQKIDLMHNDLTSLPEDMGLLRKLDCLYLQHNDILELPEFEGNEALNELHASNNFIKIIPK 356

  Fly   343 ----------------------------LKSLVRLGMRYNRLSSVPATLKNCKSMDEFNVEGNGI 379
                                        |::|.||.:..|.:|.:|.||.:...:....||||.|
  Fly   357 AMCSNLPHLKILDLRDNKITELPDELCLLRNLNRLDVSNNTISVLPVTLSSLAHLISLQVEGNPI 421

  Fly   380 TQLPDGML----------------------------ASLSGLTTITLSR---------------- 400
            ..:...:|                            ||.|...::|..|
  Fly   422 KTIRRDILQCGTTRILKTLHDRAVAKAKEEGGGVDDASTSAGISVTRLRGGQMDDGDIPGNFPDS 486

  Fly   401 -------NQF---ASYP-------------------------TGG-------------------- 410
                   |.|   .|||                         |.|
  Fly   487 FHHQQQQNGFQCPCSYPCQQQQMQQQFCVYEPLRNCQEYDRQTQGRIYEPENYQQQHQNGSLRSL 551

  Fly   411 -------------PAQF--------------------------------TNVYSINLEHNRIDKI 430
                         |..|                                |...::|||  .:..:
  Fly   552 FVQQQQQRMEYPYPGYFMYQQQQQQQFSYEQDPSSRSAVHPRWVYKLRHTRTLAVNLE--ELTSV 614

  Fly   431 PYGIF--SRAKGLTKLNMKENMLTALPLDIGTWVNMV-ELNLATNALQKLPDDIMNLQNLEILIL 492
            |..:|  :|.:|:..::...|.|:.||..:....::| ||.|:.|.:..:|..|.....:..|.|
  Fly   615 PDQVFQIARDEGVHVVDFARNQLSTLPNGLQHMKDLVTELVLSNNVIGYVPQFISQFTRISFLNL 679

  Fly   493 SNNMLKKIPNTIGNLRKLRILDLEENRIEVLPHEIGLLHELQRLILQTNQITMLPRSIGHLGNLT 557
            |||:|..:|...|.|..||.|::..||...:|:.:..|..|:.||...|.|.||  ::..|.|:.
  Fly   680 SNNLLNDLPTEFGVLNTLRELNIANNRFPCIPNCVYELQGLEILIASENHIKML--NVSGLQNMR 742

  Fly   558 HLS---VSENNLQFLPEEIGSLESLENLYINQNP 588
            .||   :..|:::.:|..:|:|.::.:|.:..||
  Fly   743 RLSTLDLRNNDIETVPPILGNLTNITHLELVGNP 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sur-8	NP_001262665.1	leucine-rich repeat	163..184	CDD:275380	6/20 (30%)
		leucine-rich repeat	185..207	CDD:275380	12/21 (57%)
		LRR_RI	204..401	CDD:238064	68/293 (23%)
		LRR_8	207..264	CDD:290566	16/56 (29%)
		leucine-rich repeat	208..230	CDD:275380	6/21 (29%)
		leucine-rich repeat	231..253	CDD:275380	7/21 (33%)
		LRR_8	252..310	CDD:290566	18/57 (32%)
		leucine-rich repeat	254..276	CDD:275380	5/21 (24%)
		leucine-rich repeat	277..299	CDD:275380	8/21 (38%)
		LRR_8	299..356	CDD:290566	25/102 (25%)
		leucine-rich repeat	300..322	CDD:275380	10/21 (48%)
		leucine-rich repeat	323..345	CDD:275380	11/67 (16%)
		LRR_8	344..403	CDD:290566	20/109 (18%)
		leucine-rich repeat	346..368	CDD:275380	8/21 (38%)
		leucine-rich repeat	369..392	CDD:275380	8/50 (16%)
		LRR_RI	<379..566	CDD:238064	63/336 (19%)
		leucine-rich repeat	417..440	CDD:275380	6/24 (25%)
		leucine-rich repeat	441..486	CDD:275380	11/45 (24%)
		LRR_8	463..520	CDD:290566	20/57 (35%)
		leucine-rich repeat	487..507	CDD:275380	8/19 (42%)
		leucine-rich repeat	510..532	CDD:275380	7/21 (33%)
		LRR_8	532..588	CDD:290566	16/58 (28%)
		leucine-rich repeat	556..578	CDD:275380	6/24 (25%)
		leucine-rich repeat	603..626	CDD:275380
f-cup	NP_001262544.1	leucine-rich repeat	111..140	CDD:275380	6/40 (15%)
		LRR_RI	155..>377	CDD:238064	65/221 (29%)
		leucine-rich repeat	158..180	CDD:275380	6/21 (29%)
		LRR_8	180..235	CDD:290566	20/54 (37%)
		leucine-rich repeat	181..203	CDD:275380	12/21 (57%)
		leucine-rich repeat	204..226	CDD:275380	6/21 (29%)
		LRR_8	225..283	CDD:290566	18/57 (32%)
		leucine-rich repeat	227..249	CDD:275380	7/21 (33%)
		leucine-rich repeat	250..272	CDD:275380	5/21 (24%)
		LRR_8	272..329	CDD:290566	24/56 (43%)
		leucine-rich repeat	273..295	CDD:275380	8/21 (38%)
		leucine-rich repeat	296..318	CDD:275380	10/21 (48%)
		LRR_8	317..375	CDD:290566	10/57 (18%)
		leucine-rich repeat	319..340	CDD:275380	10/20 (50%)
		leucine-rich repeat	341..364	CDD:275380	0/22 (0%)
		leucine-rich repeat	389..410	CDD:275380	7/20 (35%)
		leucine-rich repeat	411..430	CDD:275380	5/18 (28%)
		leucine-rich repeat	627..650	CDD:275380	4/22 (18%)
		leucine-rich repeat	651..669	CDD:275380	6/17 (35%)
		leucine-rich repeat	697..719	CDD:275380	7/21 (33%)
		LRR_8	719..777	CDD:290566	18/60 (30%)
		leucine-rich repeat	720..743	CDD:275380	9/24 (38%)
		leucine-rich repeat	744..766	CDD:275380	6/21 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467271
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47116
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840