Protein Alignment Sur-8 and LRCH4

DIOPT Version :10

• Sequence 1: NP_001262665.1
• Gene: Sur-8 / 42093
• FlyBaseID: FBgn0038504
• Length: 694
• Species: Drosophila melanogaster
• Sequence 2: XP_047276334.1
• Gene: LRCH4 / 4034
• HGNCID: 6691
• Length: 727
• Species: Homo sapiens
• Alignment Length: 272
• Identity: 74/272 - (27%)
• Similarity: 117/272 - (43%)
• Gaps: 60/272 - (22%)

  Fly   288 RELGSAIGALVNLTTLDVSHNHLEHLPEDIGNCVNLSAL---DLQHNELLDIPDSIGNLKSLVRL 349
            |....|:...|...||::|:..|:|.|.......:||.:   ||..|...::|::...|.||..|
Human    32 RSAERALEEAVATGTLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGL 96

  Fly   350 GMRYNRLSSV-PATLKNCKSMDEFNVEGNGITQLPDGMLASLSGLTTITLSRNQFASYPTGGPAQ 413
            .:.:|.|..: ||                         |.:|:.||.:.|||||.:..|.
Human    97 SLYHNCLRCLNPA-------------------------LGNLTALTYLNLSRNQLSLLPP----- 131

  Fly   414 FTNVYSINLEHNRIDKIPYGIFSRAKGLTKLNMKENMLTALPLDIGTWVNMVELNLATNALQKLP 478
                        .|.::|         |..|.:..|.|.|||.||||..::.:|::::|.||.||
Human   132 ------------YICQLP---------LRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLP 175

  Fly   479 DDIMNLQNLEILILSNNMLKKIPNTIGNLRKLRILDLEENRIEVLPHEIGLLHELQRLILQTNQI 543
            .::..|.:|..|.:..|.|..:|..:|:|..:| ||...||:..:|.....|..||.::|.:|.:
Human   176 SELCGLSSLRDLNVRRNQLSTLPEELGDLPLVR-LDFSCNRVSRIPVSFCRLRHLQVILLDSNPL 239

  Fly   544 ----TMLPRSIG 551
                ...|.|:|
Human   240 QSPPAQRPGSVG 251

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur-8	NP_001262665.1	leucine-rich repeat	163..184	CDD:275380
		LRR	185..535	CDD:443914	68/250 (27%)
		leucine-rich repeat	185..207	CDD:275380
		leucine-rich repeat	208..230	CDD:275380
		leucine-rich repeat	231..253	CDD:275380
		leucine-rich repeat	254..276	CDD:275380
		leucine-rich repeat	277..299	CDD:275380	2/10 (20%)
		leucine-rich repeat	300..322	CDD:275380	6/21 (29%)
		leucine-rich repeat	323..345	CDD:275380	7/24 (29%)
		leucine-rich repeat	346..368	CDD:275380	6/22 (27%)
		leucine-rich repeat	369..392	CDD:275380	2/22 (9%)
		leucine-rich repeat	417..440	CDD:275380	2/22 (9%)
		leucine-rich repeat	441..486	CDD:275380	18/44 (41%)
		PPP1R42	472..617	CDD:455733	27/84 (32%)
		leucine-rich repeat	487..507	CDD:275380	6/19 (32%)
		leucine-rich repeat	510..532	CDD:275380	7/21 (33%)
		leucine-rich repeat	556..578	CDD:275380
		leucine-rich repeat	603..626	CDD:275380
LRCH4	XP_047276334.1	leucine-rich repeat	46..69	CDD:275380	7/22 (32%)
		LRR	<65..>241	CDD:443914	62/227 (27%)
		leucine-rich repeat	70..92	CDD:275380	5/21 (24%)
		leucine-rich repeat	93..115	CDD:275380	8/46 (17%)
		leucine-rich repeat	116..131	CDD:275380	7/14 (50%)
		leucine-rich repeat	138..160	CDD:275380	11/21 (52%)
		leucine-rich repeat	161..183	CDD:275380	7/21 (33%)
		leucine-rich repeat	184..204	CDD:275380	6/19 (32%)
		leucine-rich repeat	206..228	CDD:275380	7/22 (32%)
		CH_SF	540..>623	CDD:469584