DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sur-8 and CG3408

DIOPT Version :9

Sequence 1:	NP_001262665.1	Gene:	Sur-8 / 42093	FlyBaseID:	FBgn0038504	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_648328.1	Gene:	CG3408 / 39107	FlyBaseID:	FBgn0036008	Length:	331	Species:	Drosophila melanogaster

Alignment Length:	254	Identity:	63/254 - (24%)
Similarity:	105/254 - (41%)	Gaps:	52/254 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   472 NALQKLPDDIMNLQNLEILILSNNMLKKIP-NTIGNLRKLRILDLEENRIEVLPHEIGLLHELQR 535
            |..:::.|:..:        ||.:.|.:|| ..|.:.:::.:|||..||:..|.....:|..|.|
  Fly    13 NVKERVVDETCD--------LSLSELSEIPVREIASFKRVTVLDLSSNRLVNLGKNFSILTRLVR 69

  Fly   536 LILQTNQITMLPRSIGHLGNLTHLSVSENNLQFLPEEIGSLESLENLYINQN---PGLEKL---- 593
            |.|..|||..||...|.|..|.||.:..|.|:.||...|.|..|..|.:..|   |..||:
  Fly    70 LDLSKNQIKFLPEDFGQLEQLRHLDLYNNCLEHLPISFGQLRRLRYLDLKGNPLTPAWEKIVGCC 134

  Fly   594 ----------PFELALCQNLKYLNIDKCPLSTIPPEIQA-------------GGPSLVLQWLKMH 635
                      ...:::|.|.|...|::..|:....:..|             ||.:...:..|.:
  Fly   135 STQKDCQQAAKNTVSICANYKPEFIERERLAAQESQKMAGAGDSSANAVQTNGGAAGGKKSTKPN 199

  Fly   636 SPYRQMXDVDGVWRTVYVGSDCYYQYELQTVNQAPGAGGNGGGGAAAAGGSASRSSDRR 694
            :...:...:.|       |.|  .:..::.||    |.|:||.||.|.|..:::.::::
  Fly   200 NKKAKAKKLAG-------GGD--NELTIKPVN----AVGSGGSGAIALGSKSTQKNNQK 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sur-8	NP_001262665.1	leucine-rich repeat	163..184	CDD:275380
		leucine-rich repeat	185..207	CDD:275380
		LRR_RI	204..401	CDD:238064
		LRR_8	207..264	CDD:290566
		leucine-rich repeat	208..230	CDD:275380
		leucine-rich repeat	231..253	CDD:275380
		LRR_8	252..310	CDD:290566
		leucine-rich repeat	254..276	CDD:275380
		leucine-rich repeat	277..299	CDD:275380
		LRR_8	299..356	CDD:290566
		leucine-rich repeat	300..322	CDD:275380
		leucine-rich repeat	323..345	CDD:275380
		LRR_8	344..403	CDD:290566
		leucine-rich repeat	346..368	CDD:275380
		leucine-rich repeat	369..392	CDD:275380
		LRR_RI	<379..566	CDD:238064	30/94 (32%)
		leucine-rich repeat	417..440	CDD:275380
		leucine-rich repeat	441..486	CDD:275380	2/13 (15%)
		LRR_8	463..520	CDD:290566	12/48 (25%)
		leucine-rich repeat	487..507	CDD:275380	6/20 (30%)
		leucine-rich repeat	510..532	CDD:275380	7/21 (33%)
		LRR_8	532..588	CDD:290566	23/58 (40%)
		leucine-rich repeat	556..578	CDD:275380	9/21 (43%)
		leucine-rich repeat	603..626	CDD:275380	6/35 (17%)
CG3408	NP_648328.1	LRR_RI	<43..>124	CDD:238064	30/80 (38%)
		leucine-rich repeat	44..66	CDD:275378	7/21 (33%)
		LRR_8	65..123	CDD:290566	23/57 (40%)
		leucine-rich repeat	67..89	CDD:275378	11/21 (52%)
		leucine-rich repeat	90..112	CDD:275378	9/21 (43%)
		leucine-rich repeat	113..124	CDD:275378	3/10 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910