DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sur-8 and scrib

DIOPT Version :9

Sequence 1:	NP_001262665.1	Gene:	Sur-8 / 42093	FlyBaseID:	FBgn0038504	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	XP_021333089.1	Gene:	scrib / 368473	ZFINID:	ZDB-GENE-030616-572	Length:	2047	Species:	Danio rerio

Alignment Length:	444	Identity:	134/444 - (30%)
Similarity:	215/444 - (48%)	Gaps:	52/444 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 LQRCRDEGIKRLDLSKSSITVIPSTV-KECVHLTELYLYSNKIGQLPPEIGCLVSLRNLALNENS 217
            |.|| :..::.:|....|:|.:|..: :....|.||.|.:|::.:||.....|.:||.|.|::|.
Zfish     7 LWRC-NRHVESVDKRHCSLTAVPDEIYRYNRSLEELLLDANQLRELPKPFFRLHNLRKLGLSDNE 70

  Fly   218 LTSLPESLQNCSQLKVLDLRHNKLAEIPPVIYRLRSLTTLYLRFNRITAVADDLRQLVNLTMLSL 282
            :..||..:.|.:||..||:..|.::|||..|...:||.......|.:|.:.|...||..|..|||
Zfish    71 IQKLPPDVANFTQLVELDISRNDISEIPENIKFCQSLEIADFSGNPLTRLPDGFTQLRGLAHLSL 135

  Fly   283 RENKIRELGSAIGALVNLTTLDVSHNHLEHLPEDIGNCVNLSALDLQHNELLDIPDSIGNLKSLV 347
            .:..::.|.:.||.|.||.||::..|.|:.||..:...|.|..|||..|.|..:||::|.|.:|.
Zfish   136 NDVSLQSLPNDIGNLSNLVTLELRENLLKSLPSSLSFLVKLEQLDLGSNVLEVLPDTLGALPNLR 200

  Fly   348 RLGMRYNRLSSVPATLKNCKSMDEFNVEGNGITQLPDGMLASLSGLTTITLSRNQFASYPTGGPA 412
            .|.:..|:|||:|..|.|.:.:...:|..|.:::||    ..:|||.
Zfish   201 ELWLDRNQLSSLPPELGNLRQLVCLDVSENRLSELP----TEISGLI------------------ 243

  Fly   413 QFTNVYSINLEHNRIDKIPYGIFSRAKGLTKLNMKENMLTALPLDIGTWVNMVELNLATNALQKL 477
                                       .||.|.:.||:|..||..||:...:..|.:..|.|..|
Zfish   244 ---------------------------ALTDLLLSENLLEILPDSIGSLKKLSILKVNQNRLVHL 281

  Fly   478 PDDIMNLQNLEILILSNNMLKKIPNTIGNLRKLRILDLEENRIEVLPHEIGLLHELQRLILQTNQ 542
            .|.|...:||..|:|:.|:|:.:|.::|.|:||..|:::.||:..:|.|:|....|..|.|:.|:
Zfish   282 TDSIGECENLTELMLTENLLQSLPRSLGKLKKLTNLNVDRNRLSSVPAELGGCVSLNVLSLRDNR 346

  Fly   543 ITMLPRSIGHLGNLTHLSVSENNLQFLPEEIGSLESLENLYINQNPGLEKLPFE 596
            :..||..:.:...|..|.|:.|.||.||..:.:| :|:.:::.:|.....|.|:
Zfish   347 LGKLPPELANATELHVLDVAGNRLQNLPFALANL-NLKAMWLAENQSQPMLKFQ 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sur-8	NP_001262665.1	leucine-rich repeat	163..184	CDD:275380	4/21 (19%)
		leucine-rich repeat	185..207	CDD:275380	8/21 (38%)
		LRR_RI	204..401	CDD:238064	68/196 (35%)
		LRR_8	207..264	CDD:290566	20/56 (36%)
		leucine-rich repeat	208..230	CDD:275380	8/21 (38%)
		leucine-rich repeat	231..253	CDD:275380	8/21 (38%)
		LRR_8	252..310	CDD:290566	20/57 (35%)
		leucine-rich repeat	254..276	CDD:275380	6/21 (29%)
		leucine-rich repeat	277..299	CDD:275380	8/21 (38%)
		LRR_8	299..356	CDD:290566	22/56 (39%)
		leucine-rich repeat	300..322	CDD:275380	7/21 (33%)
		leucine-rich repeat	323..345	CDD:275380	10/21 (48%)
		LRR_8	344..403	CDD:290566	16/58 (28%)
		leucine-rich repeat	346..368	CDD:275380	9/21 (43%)
		leucine-rich repeat	369..392	CDD:275380	4/22 (18%)
		LRR_RI	<379..566	CDD:238064	48/186 (26%)
		leucine-rich repeat	417..440	CDD:275380	0/22 (0%)
		leucine-rich repeat	441..486	CDD:275380	16/44 (36%)
		LRR_8	463..520	CDD:290566	19/56 (34%)
		leucine-rich repeat	487..507	CDD:275380	7/19 (37%)
		leucine-rich repeat	510..532	CDD:275380	7/21 (33%)
		LRR_8	532..588	CDD:290566	16/55 (29%)
		leucine-rich repeat	556..578	CDD:275380	9/21 (43%)
		leucine-rich repeat	603..626	CDD:275380
scrib	XP_021333089.1	leucine-rich repeat	14..37	CDD:275380	4/22 (18%)
		LRR	<37..306	CDD:227223	97/317 (31%)
		leucine-rich repeat	38..60	CDD:275380	8/21 (38%)
		leucine-rich repeat	61..83	CDD:275380	8/21 (38%)
		leucine-rich repeat	84..106	CDD:275380	8/21 (38%)
		leucine-rich repeat	107..129	CDD:275380	6/21 (29%)
		leucine-rich repeat	130..152	CDD:275380	8/21 (38%)
		leucine-rich repeat	153..175	CDD:275380	7/21 (33%)
		leucine-rich repeat	176..198	CDD:275380	10/21 (48%)
		LRR	<192..458	CDD:227223	70/258 (27%)
		leucine-rich repeat	199..221	CDD:275380	9/21 (43%)
		leucine-rich repeat	222..248	CDD:275380	9/74 (12%)
		leucine-rich repeat	268..290	CDD:275380	6/21 (29%)
		leucine-rich repeat	291..313	CDD:275380	8/21 (38%)
		leucine-rich repeat	314..336	CDD:275380	7/21 (33%)
		leucine-rich repeat	360..380	CDD:275380	8/19 (42%)
		PDZ_signaling	739..816	CDD:238492
		PDZ_signaling	875..952	CDD:238492
		PDZ_signaling	1004..1092	CDD:238492
		PDZ_signaling	1102..1191	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	70	1.000	Domainoid score	I9532
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910