Protein Alignment Sur-8 and Lrrc1

DIOPT Version :10

• Sequence 1: NP_001262665.1
• Gene: Sur-8 / 42093
• FlyBaseID: FBgn0038504
• Length: 694
• Species: Drosophila melanogaster
• Sequence 2: NP_001014290.1
• Gene: Lrrc1 / 367113
• RGDID: 1549773
• Length: 524
• Species: Rattus norvegicus
• Alignment Length: 405
• Identity: 131/405 - (32%)
• Similarity: 199/405 - (49%)
• Gaps: 34/405 - (8%)

  Fly   225 LQNCSQ-LKVLDLRHNKLAEIPPVIYR-LRSLTTLYLRFNRITAVADDLRQLVNLTMLSLRENKI 287
            |..|:: ::.:|.||..|..:|..||| .|||..|.|..|::..:.:...|||.|..|.|.:|::
  Rat     7 LWRCNRHVEAIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEV 71

  Fly   288 RELGSAIGALVNLTTLDVSHNHLEHLPEDIGNCVNLSALDLQHNELLDIPDSIGNLKSLVRLGMR 352
            :.|...|...:.|..||||.|.:..:||.|..|..|...|...|.|..:|:|...|::|..|.:.
  Rat    72 QRLPPEIANFMQLVELDVSRNDIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVN 136

  Fly   353 YNRLSSVPATLKNCKSMDEFNVEGNGITQLPDGMLASLSGLTTITLSRNQFASYPTGGPAQFTNV 417
            ...|.|:|..:.|..::....:..|.:|.|||. |..|..|..:.|..|:..|.|....|
  Rat   137 DISLQSLPENIGNLYNLASLELRENLLTYLPDS-LTQLRRLEELDLGNNEIYSLPESIGA----- 195

  Fly   418 YSINLEHNRIDKIPYGIFSRAKGLTKLNMKENMLTALPLDIGTWVNMVELNLATNALQKLPDDIM 482
                |.|                |..|.:..|.|:.||.:||...|::.|:::.|.|::||::|.
  Rat   196 ----LLH----------------LKDLWLDGNQLSELPQEIGNLRNLLCLDVSENRLERLPEEIS 240

  Fly   483 NLQNLEILILSNNMLKKIPNTIGNLRKLRILDLEENRIEVLPHEIGLLHELQRLILQTNQITMLP 547
            .|.:|..|::|.|:|:.:|:.||.|:||.||.|::||:..||..||....|..|:|..|::..||
  Rat   241 GLISLTDLVVSQNLLETVPDGIGKLKKLSILKLDQNRLTQLPEAIGDCENLTELVLTENRLLTLP 305

  Fly   548 RSIGHLGNLTHLSVSENNLQFLPEEIGSLESLENLYINQNPGLEKLPFELALCQNLKYLNI---- 608
            .|||.|..|.:|:...|.|..||:|||...||....|..| .|.::|.|::....|..|::
  Rat   306 TSIGKLKKLNNLNADRNKLVSLPKEIGGCCSLTVFCIRDN-RLTRIPSEVSQAMELHVLDVAGNR 369

  Fly   609 -DKCPLSTIPPEIQA 622
             ...|||....:::|
  Rat   370 LHHLPLSLTTLKLKA 384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur-8	NP_001262665.1	leucine-rich repeat	163..184	CDD:275380
		LRR	185..535	CDD:443914	100/311 (32%)
		leucine-rich repeat	185..207	CDD:275380
		leucine-rich repeat	208..230	CDD:275380	2/4 (50%)
		leucine-rich repeat	231..253	CDD:275380	8/22 (36%)
		leucine-rich repeat	254..276	CDD:275380	6/21 (29%)
		leucine-rich repeat	277..299	CDD:275380	6/21 (29%)
		leucine-rich repeat	300..322	CDD:275380	10/21 (48%)
		leucine-rich repeat	323..345	CDD:275380	7/21 (33%)
		leucine-rich repeat	346..368	CDD:275380	6/21 (29%)
		leucine-rich repeat	369..392	CDD:275380	7/22 (32%)
		leucine-rich repeat	417..440	CDD:275380	2/22 (9%)
		leucine-rich repeat	441..486	CDD:275380	16/44 (36%)
		PPP1R42	472..617	CDD:455733	57/149 (38%)
		leucine-rich repeat	487..507	CDD:275380	8/19 (42%)
		leucine-rich repeat	510..532	CDD:275380	10/21 (48%)
		leucine-rich repeat	556..578	CDD:275380	9/21 (43%)
		leucine-rich repeat	603..626	CDD:275380	6/25 (24%)
Lrrc1	NP_001014290.1	LRR	38..322	CDD:443914	99/309 (32%)
		leucine-rich repeat	38..60	CDD:275380	6/21 (29%)
		leucine-rich repeat	61..83	CDD:275380	6/21 (29%)
		leucine-rich repeat	84..106	CDD:275380	10/21 (48%)
		leucine-rich repeat	107..129	CDD:275380	7/21 (33%)
		leucine-rich repeat	130..152	CDD:275380	6/21 (29%)
		leucine-rich repeat	153..175	CDD:275380	7/22 (32%)
		leucine-rich repeat	176..198	CDD:275380	7/30 (23%)
		leucine-rich repeat	199..221	CDD:275380	8/21 (38%)
		leucine-rich repeat	222..244	CDD:275380	7/21 (33%)
		leucine-rich repeat	245..290	CDD:275380	20/44 (45%)
		PRK15370	<274..>380	CDD:185268	37/106 (35%)
		leucine-rich repeat	314..336	CDD:275380	9/21 (43%)