DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sur-8 and Scrib

DIOPT Version :9

Sequence 1:	NP_001262665.1	Gene:	Sur-8 / 42093	FlyBaseID:	FBgn0038504	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_001178808.1	Gene:	Scrib / 362938	RGDID:	1565055	Length:	1663	Species:	Rattus norvegicus

Alignment Length:	510	Identity:	143/510 - (28%)
Similarity:	224/510 - (43%)	Gaps:	97/510 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 KHPESNKPKPTTKKSKPIQADQDVIKALQRCRDEGIKRLDLSKSSITVIPSTVKECVHLTELYLY 191
            :|.||     ..|:...:|...:.|....|..:|    |.|..:.:..:|......::|.:|.|.
  Rat    12 RHVES-----VDKRHCSLQVVPEEIYRYSRSLEE----LLLDANQLRELPKPFFRLLNLRKLGLS 67

  Fly   192 SNKIGQLPPEIGCLVSLRNLALNENSLTSLPESLQNCSQLKVLDLRHNKLAEIPPVIYRLRSLTT 256
            .|:|.:||||:...:.|..|.::.|.:..:|||::.|..|::.|...|.|:.:|....:||||..
  Rat    68 DNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAH 132

  Fly   257 LYLRFNRITAVADDLRQLVNLTMLSLRENKIRELGSAIGALVNLTTLDVSHNHLEHLPEDIGNCV 321
            |.|....:.|:..|:..|.||..|.||||.::.|.:::..||.|..||:..|.||.||:.:|...
  Rat   133 LALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALP 197

  Fly   322 NLSALDLQHNELLDIPDSIGNLKSLVRLGMRYNRLSSVPATLKNCKSMDEFNVEGNGITQLPDGM 386
            ||..|.|..|:|..:|..:|||:.||.|.:..|||..:|..|
  Rat   198 NLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPVEL----------------------- 239

  Fly   387 LASLSGLTTITLSRNQFASYPTGGPAQFTNVYSINLEHNRIDKIPYGIFSRAKGLTKLNMKENML 451
                                  ||.|.                           ||.|.:.:|:|
  Rat   240 ----------------------GGLAL---------------------------LTDLLLSQNLL 255

  Fly   452 TALPLDIGTWVNMVELNLATNALQKLPDDIMNLQNLEILILSNNMLKKIPNTIGNLRKLRILDLE 516
            ..||..||....:..|.:..|.|.::.:.|.:.:||..|||:.|:|..:|.::|.|.||..|:::
  Rat   256 QRLPEGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLTALPRSLGKLTKLTNLNVD 320

  Fly   517 ENRIEVLPHEIGLLHELQRLILQTNQITMLPRSIGHLGNLTHLSVSENNLQFLPEEIGSLESLEN 581
            .|.:||||.|||....|..|.|:.|::.:||..:.|...|..|.|:.|.|:.||..:..| :|:.
  Rat   321 RNHLEVLPPEIGGCVALSVLSLRDNRLAVLPPELAHTAELHVLDVAGNRLRSLPFALTHL-NLKA 384

  Fly   582 LYINQNPGLEKLPFE----------LALCQNLKYLNIDKCPLSTIPPEIQAGGPS 626
            |::.:|.....|.|:          :..|    || :.:.||.::....|...||
  Rat   385 LWLAENQAQPMLRFQTEDDAQTGEKVLTC----YL-LPQQPLPSLEDPGQQSSPS 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sur-8	NP_001262665.1	leucine-rich repeat	163..184	CDD:275380	3/20 (15%)
		leucine-rich repeat	185..207	CDD:275380	9/21 (43%)
		LRR_RI	204..401	CDD:238064	58/196 (30%)
		LRR_8	207..264	CDD:290566	18/56 (32%)
		leucine-rich repeat	208..230	CDD:275380	7/21 (33%)
		leucine-rich repeat	231..253	CDD:275380	6/21 (29%)
		LRR_8	252..310	CDD:290566	22/57 (39%)
		leucine-rich repeat	254..276	CDD:275380	6/21 (29%)
		leucine-rich repeat	277..299	CDD:275380	8/21 (38%)
		LRR_8	299..356	CDD:290566	23/56 (41%)
		leucine-rich repeat	300..322	CDD:275380	9/21 (43%)
		leucine-rich repeat	323..345	CDD:275380	9/21 (43%)
		LRR_8	344..403	CDD:290566	8/58 (14%)
		leucine-rich repeat	346..368	CDD:275380	8/21 (38%)
		leucine-rich repeat	369..392	CDD:275380	0/22 (0%)
		LRR_RI	<379..566	CDD:238064	48/186 (26%)
		leucine-rich repeat	417..440	CDD:275380	0/22 (0%)
		leucine-rich repeat	441..486	CDD:275380	13/44 (30%)
		LRR_8	463..520	CDD:290566	18/56 (32%)
		leucine-rich repeat	487..507	CDD:275380	8/19 (42%)
		leucine-rich repeat	510..532	CDD:275380	10/21 (48%)
		LRR_8	532..588	CDD:290566	17/55 (31%)
		leucine-rich repeat	556..578	CDD:275380	8/21 (38%)
		leucine-rich repeat	603..626	CDD:275380	5/22 (23%)
Scrib	NP_001178808.1	LRR_RI	12..232	CDD:238064	74/228 (32%)
		leucine-rich repeat	14..37	CDD:275380	5/27 (19%)
		leucine-rich repeat	38..60	CDD:275380	4/25 (16%)
		LRR	39..405	CDD:227223	128/442 (29%)
		leucine-rich repeat	61..83	CDD:275380	9/21 (43%)
		leucine-rich repeat	84..106	CDD:275380	7/21 (33%)
		leucine-rich repeat	107..129	CDD:275380	6/21 (29%)
		leucine-rich repeat	130..152	CDD:275380	6/21 (29%)
		leucine-rich repeat	153..175	CDD:275380	8/21 (38%)
		leucine-rich repeat	176..198	CDD:275380	9/21 (43%)
		leucine-rich repeat	199..221	CDD:275380	9/21 (43%)
		leucine-rich repeat	268..290	CDD:275380	4/21 (19%)
		LRR_4	289..329	CDD:289563	17/39 (44%)
		leucine-rich repeat	291..313	CDD:275380	9/21 (43%)
		leucine-rich repeat	314..336	CDD:275380	10/21 (48%)
		leucine-rich repeat	360..381	CDD:275380	8/21 (38%)
		PDZ	709..797	CDD:214570
		PDZ_signaling	852..931	CDD:238492
		PDZ_signaling	986..1074	CDD:238492
		PDZ_signaling	1083..1173	CDD:238492
		AbLIM_anchor	1563..>1657	CDD:292800
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910