DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sur-8 and Phlpp

DIOPT Version :9

Sequence 1:	NP_001262665.1	Gene:	Sur-8 / 42093	FlyBaseID:	FBgn0038504	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster

Alignment Length:	555	Identity:	123/555 - (22%)
Similarity:	221/555 - (39%)	Gaps:	104/555 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 VIKALQRCRDEGIKRLDLSKSSITVIPSTVKECVHLTELYLYSNKIGQLPPEIGCLVSLRNLAL- 213
            ::||.::..|....:|.:|.|.....|..|:......|   .:...||..|:   .:||:...|
  Fly     1 MLKATRKQADPYKSKLKVSASHSGPHPLPVEVTAAEEE---QAATFGQTSPQ---KLSLKGSQLG 59

  Fly   214 ------NENSLTSLPESLQNCSQLKVLDLRHNKLAEIPPVIYRLRSLTTLYLRFNRITAVADDLR 272
                  |.|.||.| |..:|  :::||||  :.||::..:......|..|.:....:..:..|..
  Fly    60 GSILIGNYNYLTQL-EVCEN--EMEVLDL--SSLAQLETLKCSRNKLMELIINGTNLQTLVADHN 119

  Fly   273 QLVNLTMLSLRENKIRELGSAIGALVNLTTLDVSHNHLEHLPEDIGNCVNLSALDLQHNELLDIP 337
            .|.|::..:.....::           |..:|:|||:...||..:|.|.:|:|::..||.|.::.
  Fly   120 YLHNISTTNTHPVPLK-----------LQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVA 173

  Fly   338 DSIGN--LKSLVRLGMRYNRLSSVPATLKNCKSMDEFNVEGNGITQLPDGMLA-SLSGLTTITLS 399
            ..:.|  :..||.|.:.||.|..:....:...|:....::.|.:..|||...| :.:.|.|:.:|
  Fly   174 VLLRNYRITELVSLDLAYNDLKQLDQFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVS 238

  Fly   400 RNQFASYPTGGPAQFTNVYSINLEHNRIDKIPYGIFSRAKGLTKLNMKENMLTALPLD-IGTWVN 463
            .|:.::.|.........:.:::|..|.::...:.....|..|..|::..|.:..||.. :..|..
  Fly   239 CNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPE 303

  Fly   464 MVELNLATNALQKLPDDIMNLQNLEILILSNNMLKKIPNTIGNLRKLRILDLEENRIEVLPHEIG 528
            :..|.|:.|.||:||:::..|..|.:|...||:|...|. :..|..|::|||..|.::
  Fly   304 LEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQ-LAKLAMLKVLDLSHNHLD------- 360

  Fly   529 LLHELQRLILQTNQITMLPRSIGHLGNLTHLSVSENNLQFLPEEIGSLESLENLYINQNPGLEKL 593
                      :.|.:.::|..     ||.:|.:| .|||...:|                    .
  Fly   361 ----------RVNLLALVPSR-----NLKYLDLS-GNLQLQVDE--------------------Q 389

  Fly   594 PFELALCQNLKYLNIDKCPLSTIPPEIQAGG---PSLVLQWLKMHSPYRQMXDVDGVWRTVYV-- 653
            .|::...|:.::.::           :...|   .:|....::..|..|......|.|...:.
  Fly   390 QFKVCQSQSQRHWSL-----------VDVSGNNRAALPTTKIRQVSAQRNQNKTSGPWTMGFAET 443

  Fly   654 -GS-DC--YYQYELQTVNQAPGAGGNGGGGAAAAG 684
             || ||  ...|:|:..|.       ||...|..|
  Fly   444 PGSGDCRKLSVYQLRAANY-------GGSDEALYG 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sur-8	NP_001262665.1	leucine-rich repeat	163..184	CDD:275380	5/20 (25%)
		leucine-rich repeat	185..207	CDD:275380	4/21 (19%)
		LRR_RI	204..401	CDD:238064	51/206 (25%)
		LRR_8	207..264	CDD:290566	18/63 (29%)
		leucine-rich repeat	208..230	CDD:275380	9/28 (32%)
		leucine-rich repeat	231..253	CDD:275380	6/21 (29%)
		LRR_8	252..310	CDD:290566	10/57 (18%)
		leucine-rich repeat	254..276	CDD:275380	4/21 (19%)
		leucine-rich repeat	277..299	CDD:275380	0/21 (0%)
		LRR_8	299..356	CDD:290566	20/58 (34%)
		leucine-rich repeat	300..322	CDD:275380	9/21 (43%)
		leucine-rich repeat	323..345	CDD:275380	6/23 (26%)
		LRR_8	344..403	CDD:290566	16/59 (27%)
		leucine-rich repeat	346..368	CDD:275380	6/21 (29%)
		leucine-rich repeat	369..392	CDD:275380	5/23 (22%)
		LRR_RI	<379..566	CDD:238064	44/188 (23%)
		leucine-rich repeat	417..440	CDD:275380	3/22 (14%)
		leucine-rich repeat	441..486	CDD:275380	14/45 (31%)
		LRR_8	463..520	CDD:290566	20/56 (36%)
		leucine-rich repeat	487..507	CDD:275380	6/19 (32%)
		leucine-rich repeat	510..532	CDD:275380	5/21 (24%)
		LRR_8	532..588	CDD:290566	10/55 (18%)
		leucine-rich repeat	556..578	CDD:275380	7/21 (33%)
		leucine-rich repeat	603..626	CDD:275380	1/25 (4%)
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	2/18 (11%)
		LRR_8	109..169	CDD:290566	16/70 (23%)
		leucine-rich repeat	111..135	CDD:275380	3/23 (13%)
		leucine-rich repeat	136..158	CDD:275380	9/21 (43%)
		leucine-rich repeat	159..183	CDD:275380	6/23 (26%)
		leucine-rich repeat	184..209	CDD:275380	7/24 (29%)
		LRR_8	205..266	CDD:290566	13/60 (22%)
		leucine-rich repeat	210..230	CDD:275380	5/19 (26%)
		leucine-rich repeat	232..255	CDD:275380	5/22 (23%)
		LRR_RI	<256..410	CDD:238064	41/208 (20%)
		leucine-rich repeat	256..276	CDD:275380	2/19 (11%)
		LRR_8	279..359	CDD:290566	26/80 (33%)
		leucine-rich repeat	280..303	CDD:275380	6/22 (27%)
		leucine-rich repeat	304..348	CDD:275380	15/44 (34%)
		leucine-rich repeat	349..372	CDD:275380	7/44 (16%)
		PP2Cc	461..655	CDD:294085	5/18 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467272
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9772
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.870