DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sur-8 and Lrch

DIOPT Version :10

Sequence 1:NP_001262665.1 Gene:Sur-8 / 42093 FlyBaseID:FBgn0038504 Length:694 Species:Drosophila melanogaster
Sequence 2:NP_609834.2 Gene:Lrch / 35041 FlyBaseID:FBgn0032633 Length:1135 Species:Drosophila melanogaster


Alignment Length:664 Identity:157/664 - (23%)
Similarity:256/664 - (38%) Gaps:185/664 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    79 NSPANGAGGATGS---TGSGQQP---TGS-NGHSHLHNENNANMPPETRPKMVTVKHPESNKPKP 136
            :|.|.|.|.|.||   :||...|   ||| :|..|..|.:::.                      
  Fly    10 HSVAVGVGSAAGSAIGSGSASLPGSGTGSGSGIGHAGNTSSST---------------------- 52

  Fly   137 TTKKSKPIQADQDVIKALQRCRDEG--IKRLDLSKSSITVIPSTVKECVHLTELY---LYSNKIG 196
                |..:.:...:.::|:|..:|.  ...|.|:...:...|.|..: ..||:..   |..|:..
  Fly    53 ----SSALLSHSQLTRSLERILEEAHFSGELILTNRKLKDFPRTGTK-YSLTDTVIADLSRNRFA 112

  Fly   197 QLPPEIGCLVSLRNLALNENSLTSLPESLQNCSQLKVLDLRHNKLAEIPPVIYRLRSLTTLYLRF 261
            :||.|:.....|..|.|..|::.|:|||::..|.|..||||.|:|:.:|..|..| .|..|.:..
  Fly   113 ELPEEVTTFAFLETLLLYHNTIRSIPESVKQLSSLTYLDLRSNQLSSLPREICFL-PLQVLLVSN 176

  Fly   262 NRITAVADDLRQL-VNLTMLSLRENKIRELGSAIGALVNLTTLDVSHNHLEHLPEDIGNCVNLSA 325
            ||:|::.|:|.:| ..||.|....|::..|.:.:|.|.:|.:|.:..|||.:||.:: .|::|.:
  Fly   177 NRLTSLPDELGRLDQTLTDLDASYNQLANLPARLGELRSLRSLSLRSNHLLYLPREL-TCLSLIS 240

  Fly   326 LDLQHNELLDIPDSIGNLKSLVRLGMRYNRLSSVPAT------------LKNCKSMDEFNVEGNG 378
            ||:.:|::..:|..|.::.:||.|.:..|.|:|.||:            |:...:.||......|
  Fly   241 LDVSNNKIASLPLEIRHMSTLVELQLENNPLTSPPASLCMRGLVHVFKFLETQATKDEKGSRSGG 305

  Fly   379 ITQLPDGMLASLSGLTTI------TLSRNQFASYPTGGPAQFTNVYSINLEHNRIDKIPYGIFSR 437
                      :..|.||:      ..|.|...:..||.    ||    |...:::|.   | ::.
  Fly   306 ----------NYDGYTTLRRAPRHNSSGNVLEASTTGS----TN----NQRRHQVDS---G-YNT 348

  Fly   438 AKGLTK---------------LNMKENMLTA-----LPLDIGTWVNMVELNLATNALQKLPDDIM 482
            :.||.|               |:...|...|     ||..:.:..::::.:| |::...:.|:.:
  Fly   349 SDGLDKRWSHDAPTKSKTDSPLHCVSNSTAATLPRTLPSAVHSQADLMDASL-TSSTSTIVDESL 412

  Fly   483 NLQ------NLEILILSNNMLKKIPNTIGNLRKLRILDLEENRIEVLPHEIGLLHELQRLILQTN 541
            .|.      .|.....:::.....|:...::    :||.:|..:.   |..|             
  Fly   413 TLSPTASPCKLSYAHSNSSSNGSSPDQDDDI----MLDHQERTVH---HANG------------- 457

  Fly   542 QITMLPRSIGHLGNL-THLSVSENNLQFLPEEIGSLESLENLYINQNPGLEKLPFELALCQNLKY 605
                  ||...|||: |:....|...|...:||       ::|..::|.....|           
  Fly   458 ------RSGKGLGNIQTYKEYKEALKQQRNQEI-------SVYKQKHPNANHSP----------- 498

  Fly   606 LNIDKCPLSTIPPEIQAGGPSLVLQWLKMHSPYRQMXDVDGVWRTVYVGSDCYYQYELQTVNQAP 670
             |.|: .||..||.|..|..|..|       |...|                      |..||. 
  Fly   499 -NDDE-DLSPSPPSISNGSSSNTL-------PKSIMK---------------------QNSNQI- 532

  Fly   671 GAGGNGGGGAAAAG 684
            |..|||.|.|...|
  Fly   533 GHNGNGNGSANGNG 546

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sur-8NP_001262665.1 leucine-rich repeat 163..184 CDD:275380 4/20 (20%)
LRR 185..535 CDD:443914 98/397 (25%)
leucine-rich repeat 185..207 CDD:275380 7/24 (29%)
leucine-rich repeat 208..230 CDD:275380 8/21 (38%)
leucine-rich repeat 231..253 CDD:275380 10/21 (48%)
leucine-rich repeat 254..276 CDD:275380 8/22 (36%)
leucine-rich repeat 277..299 CDD:275380 7/21 (33%)
leucine-rich repeat 300..322 CDD:275380 8/21 (38%)
leucine-rich repeat 323..345 CDD:275380 6/21 (29%)
leucine-rich repeat 346..368 CDD:275380 9/33 (27%)
leucine-rich repeat 369..392 CDD:275380 3/22 (14%)
leucine-rich repeat 417..440 CDD:275380 3/22 (14%)
leucine-rich repeat 441..486 CDD:275380 11/70 (16%)
PPP1R42 472..617 CDD:455733 26/151 (17%)
leucine-rich repeat 487..507 CDD:275380 2/19 (11%)
leucine-rich repeat 510..532 CDD:275380 5/21 (24%)
leucine-rich repeat 556..578 CDD:275380 5/22 (23%)
leucine-rich repeat 603..626 CDD:275380 8/22 (36%)
LrchNP_609834.2 LRR <81..>286 CDD:443914 66/207 (32%)
leucine-rich repeat 124..146 CDD:275380 8/21 (38%)
leucine-rich repeat 147..167 CDD:275380 9/19 (47%)
leucine-rich repeat 169..192 CDD:275380 8/22 (36%)
leucine-rich repeat 193..215 CDD:275380 7/21 (33%)
leucine-rich repeat 216..237 CDD:275380 8/21 (38%)
leucine-rich repeat 238..260 CDD:275380 6/21 (29%)
leucine-rich repeat 261..279 CDD:275380 8/17 (47%)
CH_LRCH 667..755 CDD:409054
CH_SF <1075..1099 CDD:469584
Blue background indicates that the domain is not in the aligned region.

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