Protein Alignment Sur-8 and Shoc2

DIOPT Version :10

• Sequence 1: NP_001262665.1
• Gene: Sur-8 / 42093
• FlyBaseID: FBgn0038504
• Length: 694
• Species: Drosophila melanogaster
• Sequence 2: NP_001013173.1
• Gene: Shoc2 / 309548
• RGDID: 1308146
• Length: 582
• Species: Rattus norvegicus
• Alignment Length: 558
• Identity: 329/558 - (58%)
• Similarity: 418/558 - (74%)
• Gaps: 7/558 - (1%)

  Fly    85 AGGATGSTGSGQQP-TGSNGHSHLHNENNANMPPETRPKMVTVKHPESNKPKPTTKKSKPIQADQ 148
            |.|..|.....::| |..........|::|..|........|:|.|  |....|.|||    ::.
  Rat    30 ASGGFGKESKEKEPKTKGKDAKDGKKESSAAQPGVAFSVDNTIKRP--NPALGTRKKS----SNA 88

  Fly   149 DVIKALQRCRDEGIKRLDLSKSSITVIPSTVKECVHLTELYLYSNKIGQLPPEIGCLVSLRNLAL 213
            :|.|.|.:||:|...||||||.||.::|.:|||...||||||||||:..||.|:||||:|..|||
  Rat    89 EVTKELNKCREENSMRLDLSKRSIHILPPSVKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLAL 153

  Fly   214 NENSLTSLPESLQNCSQLKVLDLRHNKLAEIPPVIYRLRSLTTLYLRFNRITAVADDLRQLVNLT 278
            :||||||||:||.|..:|::||||||||.|||.|:|||.|||||||||||||||..|:|.|..|:
  Rat   154 SENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITAVEKDVRNLPRLS 218

  Fly   279 MLSLRENKIRELGSAIGALVNLTTLDVSHNHLEHLPEDIGNCVNLSALDLQHNELLDIPDSIGNL 343
            .||:|||||::|.:.||.|.||.||||:||.|||||::||||..::.||||||||||:||:||||
  Rat   219 TLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNL 283

  Fly   344 KSLVRLGMRYNRLSSVPATLKNCKSMDEFNVEGNGITQLPDGMLASLSGLTTITLSRNQFASYPT 408
            .||.|||:||||||::|.:|..|.:::|.|:|.|.|:.||:.:|:||..|.::||:||.|..||.
  Rat   284 SSLNRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPV 348

  Fly   409 GGPAQFTNVYSINLEHNRIDKIPYGIFSRAKGLTKLNMKENMLTALPLDIGTWVNMVELNLATNA 473
            |||:||:.:||:|:|||||:|||:|||||||.|:|||||:|.||:||||.|||.:|||||||||.
  Rat   349 GGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQ 413

  Fly   474 LQKLPDDIMNLQNLEILILSNNMLKKIPNTIGNLRKLRILDLEENRIEVLPHEIGLLHELQRLIL 538
            |.|:|:|:..|.:||:||||||:|||:|:.:|||||||.||||||::|.||:||..|.:||:|:|
  Rat   414 LTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVL 478

  Fly   539 QTNQITMLPRSIGHLGNLTHLSVSENNLQFLPEEIGSLESLENLYINQNPGLEKLPFELALCQNL 603
            ..||:|.|||.||||.|||||.:.||.|..||||||:||:||.||:|.||.|..||||||||..|
  Rat   479 TNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKL 543

  Fly   604 KYLNIDKCPLSTIPPEIQAGGPSLVLQWLKMHSPYRQM 641
            ..::|:.||||.:||:|.|||||.::|:|||..|||.|
  Rat   544 SIMSIENCPLSHLPPQIVAGGPSFIIQFLKMQGPYRAM 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur-8	NP_001262665.1	leucine-rich repeat	163..184	CDD:275380	12/20 (60%)
		LRR	185..535	CDD:443914	228/349 (65%)
		leucine-rich repeat	185..207	CDD:275380	16/21 (76%)
		leucine-rich repeat	208..230	CDD:275380	15/21 (71%)
		leucine-rich repeat	231..253	CDD:275380	16/21 (76%)
		leucine-rich repeat	254..276	CDD:275380	17/21 (81%)
		leucine-rich repeat	277..299	CDD:275380	12/21 (57%)
		leucine-rich repeat	300..322	CDD:275380	16/21 (76%)
		leucine-rich repeat	323..345	CDD:275380	16/21 (76%)
		leucine-rich repeat	346..368	CDD:275380	13/21 (62%)
		leucine-rich repeat	369..392	CDD:275380	10/22 (45%)
		leucine-rich repeat	417..440	CDD:275380	17/22 (77%)
		leucine-rich repeat	441..486	CDD:275380	30/44 (68%)
		PPP1R42	472..617	CDD:455733	89/144 (62%)
		leucine-rich repeat	487..507	CDD:275380	13/19 (68%)
		leucine-rich repeat	510..532	CDD:275380	14/21 (67%)
		leucine-rich repeat	556..578	CDD:275380	14/21 (67%)
		leucine-rich repeat	603..626	CDD:275380	12/22 (55%)
Shoc2	NP_001013173.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..90		16/65 (25%)
		RVxF motif, important for interaction with PP1c. /evidence=ECO:0000250|UniProtKB:Q9UQ13	63..66		0/2 (0%)
		LRR 1. /evidence=ECO:0000250|UniProtKB:Q9UQ13	101..122		11/20 (55%)
		leucine-rich repeat	104..124	CDD:275380	12/19 (63%)
		LRR	<114..448	CDD:443914	214/333 (64%)
		LRR 2. /evidence=ECO:0000250|UniProtKB:Q9UQ13	124..145		14/20 (70%)
		leucine-rich repeat	125..147	CDD:275380	16/21 (76%)
		LRR 3. /evidence=ECO:0000250|UniProtKB:Q9UQ13	147..169		15/21 (71%)
		leucine-rich repeat	148..170	CDD:275380	15/21 (71%)
		LRR 4. /evidence=ECO:0000250|UniProtKB:Q9UQ13	170..191		14/20 (70%)
		leucine-rich repeat	171..193	CDD:275380	16/21 (76%)
		LRR 5. /evidence=ECO:0000250|UniProtKB:Q9UQ13	193..215		17/21 (81%)
		leucine-rich repeat	194..216	CDD:275380	17/21 (81%)
		LRR 6. /evidence=ECO:0000250|UniProtKB:Q9UQ13	216..237		11/20 (55%)
		leucine-rich repeat	217..239	CDD:275380	12/21 (57%)
		LRR 7. /evidence=ECO:0000250|UniProtKB:Q9UQ13	239..260		15/20 (75%)
		leucine-rich repeat	240..262	CDD:275380	16/21 (76%)
		LRR 8. /evidence=ECO:0000250|UniProtKB:Q9UQ13	262..283		14/20 (70%)
		leucine-rich repeat	263..285	CDD:275380	16/21 (76%)
		LRR 9. /evidence=ECO:0000250|UniProtKB:Q9UQ13	285..307		13/21 (62%)
		leucine-rich repeat	286..332	CDD:275380	23/45 (51%)
		LRR 10. /evidence=ECO:0000250|UniProtKB:Q9UQ13	308..329		8/20 (40%)
		LRR 11. /evidence=ECO:0000250|UniProtKB:Q9UQ13	332..353		11/20 (55%)
		leucine-rich repeat	333..380	CDD:275380	30/46 (65%)
		LRR 12. /evidence=ECO:0000250|UniProtKB:Q9UQ13	356..377		14/20 (70%)
		LRR 13. /evidence=ECO:0000250|UniProtKB:Q9UQ13	380..400		13/19 (68%)
		leucine-rich repeat	381..403	CDD:275380	16/21 (76%)
		LRR	387..>560	CDD:443914	110/172 (64%)
		LRR 14. /evidence=ECO:0000250|UniProtKB:Q9UQ13	403..424		13/20 (65%)
		leucine-rich repeat	404..426	CDD:275380	14/21 (67%)
		LRR 15. /evidence=ECO:0000250|UniProtKB:Q9UQ13	426..448		14/21 (67%)
		leucine-rich repeat	427..449	CDD:275380	15/21 (71%)
		LRR 16. /evidence=ECO:0000250|UniProtKB:Q9UQ13	449..470		14/20 (70%)
		leucine-rich repeat	450..472	CDD:275380	14/21 (67%)
		LRR 17. /evidence=ECO:0000250|UniProtKB:Q9UQ13	472..494		13/21 (62%)
		leucine-rich repeat	473..495	CDD:275380	14/21 (67%)
		LRR 18. /evidence=ECO:0000250|UniProtKB:Q9UQ13	495..516		14/20 (70%)
		leucine-rich repeat	496..519	CDD:275380	15/22 (68%)
		LRR 19. /evidence=ECO:0000250|UniProtKB:Q9UQ13	518..540		14/21 (67%)
		LRR 20. /evidence=ECO:0000250|UniProtKB:Q9UQ13	542..563		9/20 (45%)
		leucine-rich repeat	543..563	CDD:275380	9/19 (47%)