DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sur-8 and Lrrd1

DIOPT Version :10

Sequence 1:NP_001262665.1 Gene:Sur-8 / 42093 FlyBaseID:FBgn0038504 Length:694 Species:Drosophila melanogaster
Sequence 2:NP_001425003.1 Gene:Lrrd1 / 296836 RGDID:1562785 Length:855 Species:Rattus norvegicus


Alignment Length:642 Identity:172/642 - (26%)
Similarity:282/642 - (43%) Gaps:96/642 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 SNGSAEAPTLCFAGGSGTAGAIAGTEE-----------------LSNANSPANGAGGATGSTGS- 94
            |:.:.|.|:      :.:...:.|.||                 |||:.||.:.....|..... 
  Rat    52 SSENTEQPS------ASSTSQLNGNEETNIEIPFSDTNIEEVIPLSNSESPQSSESSETNEAEEY 110

  Fly    95 -------GQQPTGS--NGHS------------HLHNENNANMPPETRPKMVTVKHPESNKPKPTT 138
                   |::..|.  |||.            ||..:.....|.:    :|.||:          
  Rat   111 HPVKFPIGRKFRGRTFNGHHKGFDMESDTFTVHLDAKGLQEFPVD----IVKVKY---------- 161

  Fly   139 KKSKPIQADQDVIKALQRCRDE---GIKRLDLSKSSITVIPSTVKECVHLTELYLYSNKIGQLPP 200
              .|.:..|::.||..|.....   |::.|.|.::.::.||..::...:|..|....|:|..:|.
  Rat   162 --VKYLYLDKNQIKTFQGADPGDLLGLETLSLQENGLSSIPQEIQLFHNLKVLNASYNEISHIPK 224

  Fly   201 EIGCLVSLRNLALNENSLTSLPESLQNCSQLKVLDLRHNKLAEIPPVIYRLRSLTTLYLRFNRIT 265
            |:..|.::|.|.||.|.:.|||..|:|...|:.|.|..|:|..||..:..|::|.||.|.:|::|
  Rat   225 ELLQLGNMRQLFLNSNHIESLPSGLENLRYLETLSLGKNRLTHIPDSLCGLKNLKTLNLEYNQLT 289

  Fly   266 AVADDLRQLVNLTMLSLRENKIRELGSAIGALVNLTTLDVSHNHLEHLPEDIGNCVNLSALDLQH 330
            ..:..|..|..|..|:|..|.|..|...:..|.||..|.::||.|..|..:|...:.:..|.|..
  Rat   290 IFSKSLCFLPKLVSLNLTGNMIGSLPKEVRELKNLENLLMNHNKLTFLAVEIFQLLKIKELHLAD 354

  Fly   331 NELLDIPDSIGNLKSLVRLGMRYNRLSSVPATLKNCKSMDEFNVEGNGITQLPDGM--------- 386
            |:|..|...|.|.|.|..|.:..|.|.|:|..:.:|.:::...:..|.:.:||..:         
  Rat   355 NKLEAISPKIENFKELRLLNLDNNLLQSLPKKISHCVNLESLTLSDNNLEELPKKIRKLKNLRQL 419

  Fly   387 -------------LASLSGLTTITLSRNQFASYPTGGPAQFTN---VYSINLEHNRIDKIPYGIF 435
                         ::.||.:.::..|.||.    |..|.:..|   :..:.|.:|.|...|.|:.
  Rat   420 HANRNKMIKMAEEISHLSKIHSLEFSGNQI----THVPIEIKNCKEITRVELNYNNIMYFPVGLC 480

  Fly   436 SRAKGLTKLNMKENMLTALPLDIGTWVNMVELNLATNALQKLPDDIMNLQNLEILILSNNMLKKI 500
            : .:.|..|:...|.::.:|:|:.....::.|.|..|.:....:.:.:|.|||.|.|:.|.::||
  Rat   481 A-LQSLDYLSFNGNYISEIPVDLSFSKQLLHLELNKNKITIFSEHLCSLTNLEYLDLAKNQIRKI 544

  Fly   501 PNTIGNLRKLRILDLEENRIEVLPHEIGLLHELQRLILQTNQITMLPRSIGHLGNLTHLSVSENN 565
            |:.|..:..|.:|.|.:|:.|:.|.|:..|..||.|.:..||:..:|..|..|..:..|::|.||
  Rat   545 PHCISAMLSLHVLILSDNKFEIFPKELCSLKNLQLLDISENQLHKIPSEISKLKKIQKLNLSNNN 609

  Fly   566 LQFLPEEIGSLESLENLYINQNPG--LEKLPFELALCQNLKYLNIDKCPLSTIPPEI 620
            ....|.|:..|::||:|.|:|..|  |.:||.|::....||.|||....:..||..|
  Rat   610 FTHFPAELCQLQTLEDLNISQISGKKLTRLPEEVSRMTQLKALNISNNAIKEIPRNI 666

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sur-8NP_001262665.1 leucine-rich repeat 163..184 CDD:275380 4/20 (20%)
LRR 185..535 CDD:443914 107/374 (29%)
leucine-rich repeat 185..207 CDD:275380 7/21 (33%)
leucine-rich repeat 208..230 CDD:275380 10/21 (48%)
leucine-rich repeat 231..253 CDD:275380 8/21 (38%)
leucine-rich repeat 254..276 CDD:275380 8/21 (38%)
leucine-rich repeat 277..299 CDD:275380 7/21 (33%)
leucine-rich repeat 300..322 CDD:275380 7/21 (33%)
leucine-rich repeat 323..345 CDD:275380 7/21 (33%)
leucine-rich repeat 346..368 CDD:275380 7/21 (33%)
leucine-rich repeat 369..392 CDD:275380 4/44 (9%)
leucine-rich repeat 417..440 CDD:275380 5/22 (23%)
leucine-rich repeat 441..486 CDD:275380 9/44 (20%)
PPP1R42 472..617 CDD:455733 50/146 (34%)
leucine-rich repeat 487..507 CDD:275380 9/19 (47%)
leucine-rich repeat 510..532 CDD:275380 8/21 (38%)
leucine-rich repeat 556..578 CDD:275380 7/21 (33%)
leucine-rich repeat 603..626 CDD:275380 8/18 (44%)
Lrrd1NP_001425003.1 None

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