DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sur-8 and cyr1

DIOPT Version :9

Sequence 1:	NP_001262665.1	Gene:	Sur-8 / 42093	FlyBaseID:	FBgn0038504	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_596159.1	Gene:	cyr1 / 2540810	PomBaseID:	SPBC19C7.03	Length:	1692	Species:	Schizosaccharomyces pombe

Alignment Length:	533	Identity:	143/533 - (26%)
Similarity:	236/533 - (44%)	Gaps:	69/533 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 LDLSKSSITVIPSTVKECVH-LTELYLYSNKIGQLPPEI--GCLVSLRNLALNENSLTSLPESLQ 226
            ||:|:|::.|||..:....| |..|.:..|....||.:.  .| |.|:.|.::.|..:...:.:.
pombe   410 LDISRSNLEVIPVKIYPYAHELISLNVSHNLSLDLPLDFMERC-VKLKRLDISNNLRSPRGKPIT 473

  Fly   227 NCSQLKVLDLRHNKLAEIPPVIY---RLRSLTTLYLRFNRITAVADDLRQLVNLTMLSLRENKIR 288
            ...||:||::..|.:.|:.|:|:   ...||..|.:..|::..:....|.|||||.|.|..|...
pombe   474 ALRQLEVLNMSRNDIYELDPLIFSGLSRNSLKELNIANNKLFFLPHSTRYLVNLTYLDLSYNNFV 538

  Fly   289 ELGSAIGALVNLTTLDVSHNHLEHLPEDIGNCVNLSALDLQHNELLD-IPDSIGNLKSLVRLGMR 352
            .....|..|..|.||:.|||.|..:...||:.|.|..|.||.|:|.: :|..||.||:|..:.:.
pombe   539 TFPLIITELSQLETLNFSHNLLSQISSKIGSLVKLKHLYLQFNDLSNRLPQEIGLLKNLETIDLS 603

  Fly   353 YNRLSSVPATLKNCKSMDEFNVEGNGIT----QLPDGMLASLS--GLTTI------------TLS 399
            ||.:::: |:|..|..::..||..|.::    ..|.......|  .||||            .:|
pombe   604 YNAITNI-ASLSECPKLNSINVACNLLSFYEYSNPSATFIDFSFCPLTTIDPAFSYSNLVYFDIS 667

  Fly   400 RNQFASYPTGGPAQFTNVYSINLEHNRIDKIPYGIFSRAKGLTKLNMKENMLTALPLDIGTWVNM 464
            ..:.............||.::.:.:|....|...| |..:.|..|:.....::.:..::|...::
pombe   668 HAKLIGLKDSVIETLVNVETVKVNYNHFTSISDAI-SAMQNLKYLSCTNCEMSYVSPNLGKLKHL 731

  Fly   465 VELNLATNALQKLPDDIMNLQNLEILILSNNML----------KKIPNTIGNLRKLRIL------ 513
            |.|:|..|.::..|:::..:.:|:::.||:|:|          ||:..||..|:.:|.|
pombe   732 VHLDLHANNIKIFPEEVWQVSSLKVVNLSSNILEKIKLPVATSKKLTRTISQLKIMRTLSGNPVS 796

  Fly   514 DLEENRIEVLP--HEIGLLHE---------------LQRLILQTNQITMLP-RSIGHLGNLTHLS 560
            .|..... |:|  .|:.|:..               |:.|.|..|.:|.:| :...:..:|.||.
pombe   797 SLSSQEF-VMPTVEELYLVDNRLGNDCFTALEYFKCLKVLNLSYNYLTEIPSKFFQNFSDLKHLF 860

  Fly   561 VSENNLQFLPEEIGSLESLENLYINQNPGLEKLPFELALCQNLKYLNIDKCPLSTIPPEIQAGGP 625
            ||.|.|..|.....:...||.||.|.| .|...|...||.::|::|:|....|..:..| :|...
pombe   861 VSGNELANLSISSTAQVLLETLYANGN-RLSSFPKNEALSKSLRFLDISTNNLQNLAVE-KAEKK 923

  Fly   626 SLV----LQWLKM 634
            ||.    |::|.:
pombe   924 SLTKLPQLEYLNL 936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sur-8	NP_001262665.1	leucine-rich repeat	163..184	CDD:275380	7/18 (39%)
		leucine-rich repeat	185..207	CDD:275380	6/23 (26%)
		LRR_RI	204..401	CDD:238064	65/218 (30%)
		LRR_8	207..264	CDD:290566	15/59 (25%)
		leucine-rich repeat	208..230	CDD:275380	3/21 (14%)
		leucine-rich repeat	231..253	CDD:275380	7/24 (29%)
		LRR_8	252..310	CDD:290566	21/57 (37%)
		leucine-rich repeat	254..276	CDD:275380	5/21 (24%)
		leucine-rich repeat	277..299	CDD:275380	7/21 (33%)
		LRR_8	299..356	CDD:290566	24/57 (42%)
		leucine-rich repeat	300..322	CDD:275380	9/21 (43%)
		leucine-rich repeat	323..345	CDD:275380	10/22 (45%)
		LRR_8	344..403	CDD:290566	17/76 (22%)
		leucine-rich repeat	346..368	CDD:275380	6/21 (29%)
		leucine-rich repeat	369..392	CDD:275380	5/28 (18%)
		LRR_RI	<379..566	CDD:238064	50/238 (21%)
		leucine-rich repeat	417..440	CDD:275380	5/22 (23%)
		leucine-rich repeat	441..486	CDD:275380	8/44 (18%)
		LRR_8	463..520	CDD:290566	18/72 (25%)
		leucine-rich repeat	487..507	CDD:275380	9/29 (31%)
		leucine-rich repeat	510..532	CDD:275380	7/29 (24%)
		LRR_8	532..588	CDD:290566	19/71 (27%)
		leucine-rich repeat	556..578	CDD:275380	8/21 (38%)
		leucine-rich repeat	603..626	CDD:275380	6/22 (27%)
cyr1	NP_596159.1	Ad_cyc_g-alpha	155..200	CDD:129025
		UBQ	292..387	CDD:294102
		leucine-rich repeat	409..430	CDD:275380	7/19 (37%)
		leucine-rich repeat	431..454	CDD:275380	6/23 (26%)
		LRR_RI	<441..616	CDD:238064	56/176 (32%)
		leucine-rich repeat	455..477	CDD:275380	3/21 (14%)
		LRR_8	476..537	CDD:290566	21/60 (35%)
		leucine-rich repeat	478..503	CDD:275380	7/24 (29%)
		leucine-rich repeat	504..526	CDD:275380	5/21 (24%)
		leucine-rich repeat	527..549	CDD:275380	7/21 (33%)
		LRR_8	548..607	CDD:290566	24/58 (41%)
		leucine-rich repeat	550..572	CDD:275380	9/21 (43%)
		leucine-rich repeat	573..596	CDD:275380	10/22 (45%)
		leucine-rich repeat	597..618	CDD:275380	6/21 (29%)
		leucine-rich repeat	661..684	CDD:275380	1/22 (5%)
		leucine-rich repeat	685..707	CDD:275380	5/22 (23%)
		leucine-rich repeat	708..730	CDD:275380	3/21 (14%)
		LRR_RI	<724..941	CDD:238064	57/216 (26%)
		leucine-rich repeat	754..783	CDD:275380	9/28 (32%)
		leucine-rich repeat	784..807	CDD:275380	5/23 (22%)
		leucine-rich repeat	808..831	CDD:275380	2/22 (9%)
		LRR_8	832..889	CDD:290566	20/57 (35%)
		leucine-rich repeat	832..855	CDD:275380	6/22 (27%)
		leucine-rich repeat	856..877	CDD:275380	8/20 (40%)
		leucine-rich repeat	879..901	CDD:275380	10/22 (45%)
		leucine-rich repeat	902..930	CDD:275380	8/28 (29%)
		PP2C	1032..1268	CDD:278884
		CYCc	1300..1488	CDD:214485
		Nucleotidyl_cyc_III	1323..1519	CDD:299850
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47116
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9772
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940