DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sur-8 and Lrrd1

DIOPT Version :9

Sequence 1:	NP_001262665.1	Gene:	Sur-8 / 42093	FlyBaseID:	FBgn0038504	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_766467.2	Gene:	Lrrd1 / 242838	MGIID:	3045299	Length:	853	Species:	Mus musculus

Alignment Length:	590	Identity:	153/590 - (25%)
Similarity:	272/590 - (46%)	Gaps:	89/590 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 IKRLDLSKSSITVIPSTVKECVHLTELYLYSNKIGQLPPEIGCLVSLRNLALNENSLTSLPESLQ 226
            :|.|:.|.:.|:.||..:.:..::.:|.|.||.|..||..:..|..|..|:|.:|.||.:|:||.
Mouse   207 LKILNASYNEISQIPKELLQLENMRQLLLNSNHIDTLPSGLEHLRYLETLSLGKNMLTYIPDSLS 271

  Fly   227 NCSQLKVLDLRHNKL-----------------------AEIPPVIYRLRSLTTLYLRFNRITAVA 268
            :...|::|:|.:|:|                       ..:|..:..|::|.:|.:..|::|.:|
Mouse   272 SLKNLRILNLEYNQLTIFSKSLCFLPKLNSLNLTGNMIGSLPKEVRELKNLESLLMDHNKLTFLA 336

  Fly   269 DDLRQLVNLTMLSLRENKIRELGSAIGALVNLTTLDVSHNHLEHLPEDIGNCVNLSALDLQHNEL 333
            .::.||..:..|.|.:||:..:...|.....|..|::..|.|:.:|:.|.:||||.:|.|..|.:
Mouse   337 VEIFQLPKIKELHLADNKLEAISPKIENFKELRLLNLDKNLLQSIPKKISHCVNLESLSLSDNNI 401

  Fly   334 LDIPDSIGNLKSLVRLGMRYNRLSSVPATLKNCKSMDEFNVEGNGITQLPDGMLASLSGLTTITL 398
            .::|..|..||:|.:|.:..|::.::...:.:..::......||.||.:|. .:.:...:|.:.|
Mouse   402 EELPKKIRKLKNLRQLHVNRNKMITMTEEISHLSNIHILEFSGNQITHVPI-EIKNCRKITRVEL 465

  Fly   399 SRNQFASYPTGGPA-QFTNVYSINLEHNRIDKIPYGIFSRAKGLTKLNMKENMLTALPLDIGTWV 462
            :.|....:|.|..| |..:..|.|  .|.|.:||..: |.:|.|..|.:..|.||.....:.:..
Mouse   466 NYNNIMYFPVGLCALQSLDYLSFN--GNYISEIPVDM-SFSKQLLHLELNRNKLTVFSKHLCSLT 527

  Fly   463 NMVELNLATNALQKLPDDIMNLQNLEILILSNNMLKKIPNTIGNLRKLRILDLEENRIEVLPHEI 527
            |:..|:||.|.:..:|..|..:.:|.:||||:|..:..|..:.:|:.||:||:.||:::.:|.||
Mouse   528 NLEYLDLAKNQIMTIPSCISAMVSLHVLILSDNKFESFPKELCSLKNLRVLDISENKLQKIPLEI 592

  Fly   528 GLLHELQRLILQTN--------------------------QITMLPRSIGHLGNLTHLSVSENNL 566
            ..|..:|:|.|..|                          ::|.||..:.|:..|..|::|.|.:
Mouse   593 SKLKRIQKLNLSNNIFTNFPVELCQLQTLEELNISQTSGKKLTRLPEEVSHMTQLKILNISNNAI 657

  Fly   567 QFLPEEIGSLESLENLYINQNP----------------------GLEKLPFELALCQNLKYLNID 609
            :.:|:.||.|.||.:.|.:.|.                      .:..||..:....:||.:|.|
Mouse   658 KDIPKNIGELRSLVSFYASNNQISSLPSSFLSLEVLQSLDLRGNNMTALPSGIYKLSSLKEINFD 722

  Fly   610 KCPLSTIPPEIQAGGPSLVLQWLKMHSPYRQMXD------VDGVWRTVYVG-SDCYYQYELQTVN 667
            ..||...|.||..|      :.:.|.:.|.|. |      ::.::..|... ::..:::..|.:|
Mouse   723 DNPLMRPPMEICKG------KEMHMITCYLQRADERDEKILEKIFNIVANSITETNFEFLQQKLN 781

  Fly   668 QAPGA 672
            .|..|
Mouse   782 MASSA 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sur-8	NP_001262665.1	leucine-rich repeat	163..184	CDD:275380	6/20 (30%)
		leucine-rich repeat	185..207	CDD:275380	8/21 (38%)
		LRR_RI	204..401	CDD:238064	56/219 (26%)
		LRR_8	207..264	CDD:290566	19/79 (24%)
		leucine-rich repeat	208..230	CDD:275380	9/21 (43%)
		leucine-rich repeat	231..253	CDD:275380	7/44 (16%)
		LRR_8	252..310	CDD:290566	15/57 (26%)
		leucine-rich repeat	254..276	CDD:275380	7/21 (33%)
		leucine-rich repeat	277..299	CDD:275380	5/21 (24%)
		LRR_8	299..356	CDD:290566	20/56 (36%)
		leucine-rich repeat	300..322	CDD:275380	7/21 (33%)
		leucine-rich repeat	323..345	CDD:275380	7/21 (33%)
		LRR_8	344..403	CDD:290566	12/58 (21%)
		leucine-rich repeat	346..368	CDD:275380	3/21 (14%)
		leucine-rich repeat	369..392	CDD:275380	5/22 (23%)
		LRR_RI	<379..566	CDD:238064	60/213 (28%)
		leucine-rich repeat	417..440	CDD:275380	7/22 (32%)
		leucine-rich repeat	441..486	CDD:275380	12/44 (27%)
		LRR_8	463..520	CDD:290566	21/56 (38%)
		leucine-rich repeat	487..507	CDD:275380	7/19 (37%)
		leucine-rich repeat	510..532	CDD:275380	10/21 (48%)
		LRR_8	532..588	CDD:290566	19/81 (23%)
		leucine-rich repeat	556..578	CDD:275380	8/21 (38%)
		leucine-rich repeat	603..626	CDD:275380	10/22 (45%)
Lrrd1	NP_766467.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..78
		LRR 1	133..157
		leucine-rich repeat	139..159	CDD:275380
		LRR 2	159..180
		leucine-rich repeat	160..183	CDD:275380
		LRR_8	183..240	CDD:290566	10/32 (31%)
		LRR 3	183..204
		leucine-rich repeat	184..206	CDD:275380
		LRR 4	206..227		6/19 (32%)
		leucine-rich repeat	207..229	CDD:275380	6/21 (29%)
		LRR 5	229..251		7/21 (33%)
		leucine-rich repeat	230..252	CDD:275380	8/21 (38%)
		LRR_8	251..309	CDD:290566	14/57 (25%)
		LRR 6	252..274		9/21 (43%)
		leucine-rich repeat	253..275	CDD:275380	9/21 (43%)
		LRR 7	275..297		5/21 (24%)
		leucine-rich repeat	276..298	CDD:275380	5/21 (24%)
		LRR 8	298..319		1/20 (5%)
		leucine-rich repeat	299..321	CDD:275380	2/21 (10%)
		LRR_RI	315..582	CDD:238064	77/270 (29%)
		LRR_8	320..378	CDD:290566	15/57 (26%)
		LRR 9	321..342		5/20 (25%)
		leucine-rich repeat	322..344	CDD:275380	7/21 (33%)
		LRR 10	344..365		5/20 (25%)
		leucine-rich repeat	345..367	CDD:275380	5/21 (24%)
		LRR_8	366..424	CDD:290566	20/57 (35%)
		LRR 11	367..388		6/20 (30%)
		leucine-rich repeat	368..390	CDD:275380	7/21 (33%)
		LRR 12	390..411		7/20 (35%)
		leucine-rich repeat	391..436	CDD:275380	11/44 (25%)
		LRR 13	413..435		3/21 (14%)
		LRR 14	436..457		5/21 (24%)
		LRR 15	459..481		6/21 (29%)
		leucine-rich repeat	460..482	CDD:275380	6/21 (29%)
		LRR_8	482..539	CDD:290566	18/59 (31%)
		LRR 16	482..503		7/23 (30%)
		leucine-rich repeat	483..505	CDD:275380	7/24 (29%)
		LRR 17	505..527		5/21 (24%)
		leucine-rich repeat	506..528	CDD:275380	5/21 (24%)
		LRR 18	528..549		7/20 (35%)
		LRR_8	551..606	CDD:290566	21/54 (39%)
		LRR 19	551..573		7/21 (33%)
		leucine-rich repeat	552..574	CDD:275380	8/21 (38%)
		LRR_4	573..612	CDD:289563	14/38 (37%)
		LRR 20	574..596		9/21 (43%)
		leucine-rich repeat	575..597	CDD:275380	10/21 (48%)
		LRR 21	597..618		4/20 (20%)
		leucine-rich repeat	598..620	CDD:275380	4/21 (19%)
		LRR 22	620..641		3/20 (15%)
		leucine-rich repeat	621..646	CDD:275380	4/24 (17%)
		LRR 23	646..668		7/21 (33%)
		leucine-rich repeat	647..669	CDD:275380	8/21 (38%)
		LRR 24	669..690		4/20 (20%)
		leucine-rich repeat	670..692	CDD:275380	3/21 (14%)
		LRR 25	692..713		2/20 (10%)
		LRR 26	715..736		9/20 (45%)
		leucine-rich repeat	716..736	CDD:275380	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45752
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010