Protein Alignment Sur-8 and Lrrc7

DIOPT Version :10

• Sequence 1: NP_001262665.1
• Gene: Sur-8 / 42093
• FlyBaseID: FBgn0038504
• Length: 694
• Species: Drosophila melanogaster
• Sequence 2: NP_001357710.1
• Gene: Lrrc7 / 242274
• MGIID: 2676665
• Length: 1575
• Species: Mus musculus
• Alignment Length: 508
• Identity: 153/508 - (30%)
• Similarity: 229/508 - (45%)
• Gaps: 96/508 - (18%)

  Fly   127 KHPESNKP--KPTTKKSKPIQADQDVIKALQRCR-----DEGIKRLDLSKSSITVIPSTVKECVH 184
            |.||....  :.|||:.        :|..|..||     :|.|..||.|..|:..:|   ||..:
Mouse    28 KRPEEELQCLEMTTKRK--------LIGRLVPCRCFRGEEEIISVLDYSHCSLQQVP---KEVFN 81

  Fly   185 ----LTELYLYSNKIGQLPPEIGCLVSLRNLALNENSLTSLPESLQNCSQLKVLDLRHNKLAEIP 245
                |.||||.:|:|.:||.::....:||.|::.:|.|:|||.|:.:...||.||:..|.:.|.|
Mouse    82 FERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSSLPTSIASLVNLKELDISKNGVQEFP 146

  Fly   246 PVIYRLRSLTTLYLRFNRITAVADDLRQLVNLTMLSLRENKIRELGSAIGALVNLTTLDVSHNHL 310
            ..|...:.||.:....|.|:.:.|...||:|||.|.|.:..:..|.:..|.||.|..|::..|||
Mouse   147 ENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHL 211

  Fly   311 EHLPEDIGNCVNLSALDLQHNELLDIPDSIGNLKSLVRLGMRYNRLSSVPATLKNCKSMDEFNVE 375
            :.||:.:.....|..|||.:||..::|:.:..:::|..|.|..|.|..:|
Mouse   212 KTLPKSMHKLAQLERLDLGNNEFSELPEVLDQIQNLRELWMDNNALQVLP--------------- 261

  Fly   376 GNGITQLPDGMLASLSGLTTITLSRNQFASYPTGGPAQFTNVYSINLEHNRIDKIPYGIFSRAKG 440
                                                                     |...:.|.
Mouse   262 ---------------------------------------------------------GSIGKLKM 269

  Fly   441 LTKLNMKENMLTALPLDIGTWVNMVELNLATNALQKLPDDIMNLQNLEILILSNNMLKKIPNTIG 505
            |..|:|.:|.:..:.:||.....:.:|.|::|.||:|||.|..|:.|..|.:.:|.|..:|||||
Mouse   270 LVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIG 334

  Fly   506 NLRKLRILDLEENRIEVLPHEIGLLHELQRLILQTNQITMLPRSIGHLGNLTHLSVSENNLQFLP 570
            ||..|...|...|.:|.||..||.||.|:.|.:..|.:..|||.||...|:|.:|:..|.|:|||
Mouse   335 NLSLLEEFDCSCNELESLPPTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLP 399

  Fly   571 EEIGSLESLENLYINQNPGLEKLPFELALCQNLKYLNI-DKCPLSTIPPEIQA 622
            ||||.::.|..|.::.| .|:.|||.....:.|..|.: |....:.||.:.:|
Mouse   400 EEIGQMQRLRVLNLSDN-RLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEA 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur-8	NP_001262665.1	leucine-rich repeat	163..184	CDD:275380	7/20 (35%)
		LRR	185..535	CDD:443914	102/349 (29%)
		leucine-rich repeat	185..207	CDD:275380	9/21 (43%)
		leucine-rich repeat	208..230	CDD:275380	9/21 (43%)
		leucine-rich repeat	231..253	CDD:275380	8/21 (38%)
		leucine-rich repeat	254..276	CDD:275380	7/21 (33%)
		leucine-rich repeat	277..299	CDD:275380	7/21 (33%)
		leucine-rich repeat	300..322	CDD:275380	7/21 (33%)
		leucine-rich repeat	323..345	CDD:275380	7/21 (33%)
		leucine-rich repeat	346..368	CDD:275380	6/21 (29%)
		leucine-rich repeat	369..392	CDD:275380	0/22 (0%)
		leucine-rich repeat	417..440	CDD:275380	1/22 (5%)
		leucine-rich repeat	441..486	CDD:275380	16/44 (36%)
		PPP1R42	472..617	CDD:455733	59/145 (41%)
		leucine-rich repeat	487..507	CDD:275380	9/19 (47%)
		leucine-rich repeat	510..532	CDD:275380	9/21 (43%)
		leucine-rich repeat	556..578	CDD:275380	11/21 (52%)
		leucine-rich repeat	603..626	CDD:275380	6/21 (29%)
Lrrc7	NP_001357710.1	PRK15370	<15..>280	CDD:185268	87/334 (26%)
		leucine-rich repeat	64..85	CDD:275380	7/23 (30%)
		leucine-rich repeat	86..108	CDD:275380	9/21 (43%)
		leucine-rich repeat	109..131	CDD:275380	9/21 (43%)
		leucine-rich repeat	132..177	CDD:275380	15/44 (34%)
		LRR	175..>451	CDD:443914	101/348 (29%)
		leucine-rich repeat	178..200	CDD:275380	7/21 (33%)
		leucine-rich repeat	201..223	CDD:275380	7/21 (33%)
		leucine-rich repeat	224..246	CDD:275380	7/21 (33%)
		leucine-rich repeat	247..269	CDD:275380	7/93 (8%)
		leucine-rich repeat	270..292	CDD:275380	6/21 (29%)
		leucine-rich repeat	316..336	CDD:275380	9/19 (47%)
		leucine-rich repeat	339..361	CDD:275380	9/21 (43%)
		leucine-rich repeat	362..384	CDD:275380	8/21 (38%)
		leucine-rich repeat	385..407	CDD:275380	11/21 (52%)
		leucine-rich repeat	408..430	CDD:275380	7/22 (32%)
		PDZ_densin_erbin-like	1485..1571	CDD:467231