Protein Alignment Sur-8 and SCRIB

DIOPT Version :9

• Sequence 1: NP_001262665.1
• Gene: Sur-8 / 42093
• FlyBaseID: FBgn0038504
• Length: 694
• Species: Drosophila melanogaster
• Sequence 2: NP_874365.3
• Gene: SCRIB / 23513
• HGNCID: 30377
• Length: 1655
• Species: Homo sapiens
• Alignment Length: 517
• Identity: 146/517 - (28%)
• Similarity: 226/517 - (43%)
• Gaps: 103/517 - (19%)

  Fly   127 KHPESNKPKPTTKKSKPIQADQDVIKALQRCRDEGIKRLDLSKSSITVIPSTVKECVHLTELYLY 191
            :|.||     ..|:...:||..:.|....|..:|    |.|..:.:..:|......::|.:|.|.
Human    12 RHVES-----VDKRHCSLQAVPEEIYRYSRSLEE----LLLDANQLRELPKPFFRLLNLRKLGLS 67

  Fly   192 SNKIGQLPPEIGCLVSLRNLALNENSLTSLPESLQNCSQLKVLDLRHNKLAEIPPVIYRLRSLTT 256
            .|:|.:||||:...:.|..|.::.|.:..:|||::.|..|::.|...|.|:.:|....:||||..
Human    68 DNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAH 132

  Fly   257 LYLRFNRITAVADDLRQLVNLTMLSLRENKIRELGSAIGALVNLTTLDVSHNHLEHLPEDIGNCV 321
            |.|....:.|:..|:..|.||..|.||||.::.|.:::..||.|..||:..|.||.||:.:|...
Human   133 LALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALP 197

  Fly   322 NLSALDLQHNELLDIPDSIGNLKSLVRLGMRYNRLSSVPATLKNCKSMDEFNVEGNGITQLPDGM 386
            ||..|.|..|:|..:|..:|||:.||.|.:..|||..:|
Human   198 NLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELP-------------------------- 236

  Fly   387 LASLSGLTTITLSRNQFASYPTGGPAQFTNVYSINLEHNRIDKIPYGIFSRAKGLTKLNMKENML 451
             |.|.||..                                             ||.|.:.:|:|
Human   237 -AELGGLVL---------------------------------------------LTDLLLSQNLL 255

  Fly   452 TALPLDIGTWVNMVELNLATNALQKLPDDIMNLQNLEILILSNNMLKKIPNTIGNLRKLRILDLE 516
            ..||..||....:..|.:..|.|.::.:.|.:.:||..|||:.|:|..:|.::|.|.||..|:::
Human   256 RRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVD 320

  Fly   517 ENRIEVLPHEIGLLHELQRLILQTNQITMLPRSIGHLGNLTHLSVSENNLQFLPEEIGSLESLEN 581
            .|.:|.||.|||....|..|.|:.|::.:||..:.|...|..|.|:.|.||.||..:..| :|:.
Human   321 RNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHL-NLKA 384

  Fly   582 LYINQNPGLEKLPFE----------LALCQNLKYLNIDKCPLSTIPPEIQAGGP--SLVLQW 631
            |::.:|.....|.|:          :..|    || :.:.|    ||.::..|.  ||...|
Human   385 LWLAENQAQPMLRFQTEDDARTGEKVLTC----YL-LPQQP----PPSLEDAGQQGSLSETW 437

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur-8	NP_001262665.1	leucine-rich repeat	163..184	CDD:275380	3/20 (15%)
		leucine-rich repeat	185..207	CDD:275380	9/21 (43%)
		LRR_RI	204..401	CDD:238064	61/196 (31%)
		LRR_8	207..264	CDD:290566	18/56 (32%)
		leucine-rich repeat	208..230	CDD:275380	7/21 (33%)
		leucine-rich repeat	231..253	CDD:275380	6/21 (29%)
		LRR_8	252..310	CDD:290566	22/57 (39%)
		leucine-rich repeat	254..276	CDD:275380	6/21 (29%)
		leucine-rich repeat	277..299	CDD:275380	8/21 (38%)
		LRR_8	299..356	CDD:290566	23/56 (41%)
		leucine-rich repeat	300..322	CDD:275380	9/21 (43%)
		leucine-rich repeat	323..345	CDD:275380	9/21 (43%)
		LRR_8	344..403	CDD:290566	11/58 (19%)
		leucine-rich repeat	346..368	CDD:275380	7/21 (33%)
		leucine-rich repeat	369..392	CDD:275380	2/22 (9%)
		LRR_RI	<379..566	CDD:238064	48/186 (26%)
		leucine-rich repeat	417..440	CDD:275380	0/22 (0%)
		leucine-rich repeat	441..486	CDD:275380	13/44 (30%)
		LRR_8	463..520	CDD:290566	18/56 (32%)
		leucine-rich repeat	487..507	CDD:275380	8/19 (42%)
		leucine-rich repeat	510..532	CDD:275380	9/21 (43%)
		LRR_8	532..588	CDD:290566	18/55 (33%)
		leucine-rich repeat	556..578	CDD:275380	9/21 (43%)
		leucine-rich repeat	603..626	CDD:275380	6/24 (25%)
SCRIB	NP_874365.3	Sufficient for targeting to adherens junction and to inhibit cell proliferation	1..818		146/517 (28%)
		LRR_RI	12..232	CDD:238064	75/228 (33%)
		leucine-rich repeat	14..37	CDD:275380	6/27 (22%)
		leucine-rich repeat	38..60	CDD:275380	4/25 (16%)
		LRR	39..401	CDD:227223	128/438 (29%)
		leucine-rich repeat	61..83	CDD:275380	9/21 (43%)
		leucine-rich repeat	84..106	CDD:275380	7/21 (33%)
		leucine-rich repeat	107..129	CDD:275380	6/21 (29%)
		leucine-rich repeat	130..152	CDD:275380	6/21 (29%)
		leucine-rich repeat	153..175	CDD:275380	8/21 (38%)
		leucine-rich repeat	176..198	CDD:275380	9/21 (43%)
		leucine-rich repeat	199..221	CDD:275380	9/21 (43%)
		leucine-rich repeat	268..290	CDD:275380	4/21 (19%)
		leucine-rich repeat	291..313	CDD:275380	9/21 (43%)
		leucine-rich repeat	314..336	CDD:275380	9/21 (43%)
		leucine-rich repeat	360..381	CDD:275380	9/21 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	417..440		7/25 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	459..604
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	633..702
		Interaction with ARHGEF7. /evidence=ECO:0000269|PubMed:15182672	717..1229
		PDZ	725..813	CDD:214570
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	827..853
		PDZ_signaling	860..947	CDD:238492
		PDZ_signaling	1002..1090	CDD:238492
		PDZ_signaling	1098..1189	CDD:238492
		Interaction with tick-borne encephalitis virus RNA-directed RNA polymerase NS5. /evidence=ECO:0000269|PubMed:18042258	1105..1117
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1227..1246
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1277..1489
		AbLIM_anchor	1555..>1593	CDD:292800

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910