DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sur-8 and LRRC8B

DIOPT Version :10

Sequence 1:NP_001262665.1 Gene:Sur-8 / 42093 FlyBaseID:FBgn0038504 Length:694 Species:Drosophila melanogaster
Sequence 2:NP_056165.1 Gene:LRRC8B / 23507 HGNCID:30692 Length:803 Species:Homo sapiens


Alignment Length:483 Identity:122/483 - (25%)
Similarity:204/483 - (42%) Gaps:97/483 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   169 KSSITVIPSTVKE---CVHLTELY--LYSNKIGQLPPEIGCLVSLRNLALNENSLTSLPESLQNC 228
            ||:.:.||....:   .:||.:.|  |||.:......|:           :||.|..:     |.
Human   353 KSNYSDIPDVKNDFAFILHLADQYDPLYSKRFSIFLSEV-----------SENKLKQI-----NL 401

  Fly   229 SQLKVLDLRHNKLAEIPPVIYRLRSLTTLYLRFNRITAVADDLRQLVNLTMLSLRENKIRELGSA 293
            :....::...:||.:        .:...:.|....:..:.|::.:|..:.:|||......:|.||
Human   402 NNEWTVEKLKSKLVK--------NAQDKIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSA 458

  Fly   294 IGALVNLTTLDVSHNHL--EH-----LPEDIGNCVNLSALDLQHNELLDIPDSIGNLKSLVRLGM 351
            :..||||..|.|.|:.|  :|     |.|      ||..|.|:..|:..||..:.:||:|..|  
Human   459 VSQLVNLKELRVYHSSLVVDHPALAFLEE------NLKILRLKFTEMGKIPRWVFHLKNLKEL-- 515

  Fly   352 RYNRLSSVPATLKNC---KSMDEFNVEG-------------NGITQLPDGMLASLSGLTTITLSR 400
                      .|..|   :.:....:||             :.::::|..:...|..|..::|..
Human   516 ----------YLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDN 570

  Fly   401 NQFASYPTGGPAQFTNVYSINLEHNRIDKIPYGIFSRAKGLTKLNMKENMLTALPLDIGTWVNMV 465
            ............:..|:.|:.|....:::||:.|||       ||                 |:.
Human   571 EGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFS-------LN-----------------NLH 611

  Fly   466 ELNLATNALQKLPDDI--MNLQNLEILILSNNMLKKIPNTIGNLRKLRILDLEENRIEVLPHEIG 528
            ||:|..|.|:.:.:.|  .:||||..|.|.:|.:..||..||.|..|..|.|:.|.||.||.::.
Human   612 ELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLF 676

  Fly   529 LLHELQRLILQTNQITMLPRSIGHLGNLTHLSVSENNLQFLPEEIGSLESLENLYINQNPGLEKL 593
            |..:|..|.|..|.:|.:|..|.:|.||.:.:|:.||::.||:.:...:.|:.|.:.:| .|..|
Human   677 LCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKN-SLMNL 740

  Fly   594 PFELALCQNLKYLNIDKCPLSTIPPEIQ 621
            ...:....||.:|.:....|.|:|||::
Human   741 SPHVGELSNLTHLELIGNYLETLPPELE 768

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sur-8NP_001262665.1 leucine-rich repeat 163..184 CDD:275380 4/17 (24%)
LRR 185..535 CDD:443914 90/376 (24%)
leucine-rich repeat 185..207 CDD:275380 6/23 (26%)
leucine-rich repeat 208..230 CDD:275380 4/21 (19%)
leucine-rich repeat 231..253 CDD:275380 2/21 (10%)
leucine-rich repeat 254..276 CDD:275380 3/21 (14%)
leucine-rich repeat 277..299 CDD:275380 7/21 (33%)
leucine-rich repeat 300..322 CDD:275380 8/28 (29%)
leucine-rich repeat 323..345 CDD:275380 7/21 (33%)
leucine-rich repeat 346..368 CDD:275380 4/24 (17%)
leucine-rich repeat 369..392 CDD:275380 4/35 (11%)
leucine-rich repeat 417..440 CDD:275380 7/22 (32%)
leucine-rich repeat 441..486 CDD:275380 10/46 (22%)
PPP1R42 472..617 CDD:455733 49/146 (34%)
leucine-rich repeat 487..507 CDD:275380 8/19 (42%)
leucine-rich repeat 510..532 CDD:275380 9/21 (43%)
leucine-rich repeat 556..578 CDD:275380 6/21 (29%)
leucine-rich repeat 603..626 CDD:275380 7/19 (37%)
LRRC8BNP_056165.1 Pannexin_like 1..334 CDD:463622
LRR 1 464..486 7/21 (33%)
leucine-rich repeat 465..488 CDD:275380 8/28 (29%)
LRR 2 488..509 7/20 (35%)
leucine-rich repeat 489..511 CDD:275380 7/21 (33%)
LRR 511..>789 CDD:443914 76/295 (26%)
LRR 3 511..532 4/32 (13%)
leucine-rich repeat 512..539 CDD:275380 6/38 (16%)
LRR 4 539..559 1/19 (5%)
leucine-rich repeat 540..562 CDD:275380 2/21 (10%)
LRR 5 562..582 2/19 (11%)
leucine-rich repeat 563..609 CDD:275380 12/69 (17%)
LRR 6 586..607 8/27 (30%)
LRR 7 609..630 7/20 (35%)
leucine-rich repeat 610..634 CDD:275380 7/23 (30%)
LRR 8 634..655 9/20 (45%)
leucine-rich repeat 635..657 CDD:275380 9/21 (43%)
LRR 9 657..678 8/20 (40%)
leucine-rich repeat 658..680 CDD:275380 9/21 (43%)
LRR 10 680..701 7/20 (35%)
leucine-rich repeat 681..703 CDD:275380 8/21 (38%)
LRR 11 703..724 7/20 (35%)
leucine-rich repeat 704..726 CDD:275380 6/21 (29%)
LRR 12 726..747 5/21 (24%)
leucine-rich repeat 727..749 CDD:275380 5/22 (23%)
LRR 13 749..771 8/20 (40%)
leucine-rich repeat 750..772 CDD:275380 7/19 (37%)
leucine-rich repeat 773..796 CDD:275380
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.