DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sur-8 and PHLPP1

DIOPT Version :9

Sequence 1:	NP_001262665.1	Gene:	Sur-8 / 42093	FlyBaseID:	FBgn0038504	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_919431.2	Gene:	PHLPP1 / 23239	HGNCID:	20610	Length:	1717	Species:	Homo sapiens

Alignment Length:	528	Identity:	143/528 - (27%)
Similarity:	228/528 - (43%)	Gaps:	118/528 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 IKALQRCRDEGIKRLDLSKSSITVIPSTVKECVHLTELYLYSNKIGQLPPEIGCLVSLRNLALNE 215
            :..|||...  :|.|:||.:.:...|..|.....|.||.:..|.:..:|..:|.:.:|:...|:.
Human   684 LNELQRFTK--LKSLNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDG 746

  Fly   216 NSLTSLPESLQNCSQLKVLDLRHNKLAEIPPVIYRLRSLTTLY---------------------- 258
            |.|.|||..|:|..||..|.|..|:..:||.|:.:|.::..|.
Human   747 NFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKH 811

  Fly   259 --LRFNRI-TAVADDLRQLVNLTMLSLRENKIRELGSAI-------------------------- 294
              ||.|.| ..:||::..|.::|.|.||:||:.:|.:.|
Human   812 VDLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVLHCERNQLVTLDICGYFLKA 876

  Fly   295 -----GALVN---------LTTLDVSHNHLEHLPEDIGNCVNLSALDLQHNELLDIPDSIGNLKS 345
                 ..||.         |:.:|||.|.||::||.:.....|..||:.||::.::|..:....|
Human   877 LYASSNELVQLDVYPVPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSS 941

  Fly   346 LVRLGMRYNRLSSVPATLKNCKSMDEFNVEGNGITQLPDGMLASLSGLTTITLSRNQFASYPTGG 410
            |.:|...:|:|:.:|..|:. .|::..:|:.|.:.:||..:|.....|..:..|.|:..|.|
Human   942 LRKLLAGHNQLARLPERLER-TSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLP--- 1002

  Fly   411 PAQFTNVYSINLEHNRIDKIPYGIFSRAKGLTKLNMKENMLT--ALPLDIGTWVNMVELNLATNA 473
            ||      :::.|.|.|             |.:|.:..|.||  .:||..| ..::..|::|.|.
Human  1003 PA------TLSEETNSI-------------LQELYLTNNSLTDKCVPLLTG-HPHLKILHMAYNR 1047

  Fly   474 LQKLPDDIM-NLQNLEILILSNNMLKKIPNTIGNLRKLRILDLEENRIEVLPHEIGLLHELQRLI 537
            ||..|...| .|:.||.:.||.|.||.||.||.|.|::..:....|.|||.| |:..|.|::.:.
Human  1048 LQSFPASKMAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFP-EVMQLPEIKCVD 1111

  Fly   538 LQTNQITMLPRSIGHLGNLTHLSVSENNLQFLPEEIGSLESLENLYINQNPGLEKLPFELALCQN 602
            |..|:             |:.:::.||    ||.:      |:.|.:..||.|......|.|..|
Human  1112 LSCNE-------------LSEVTLPEN----LPPK------LQELDLTGNPRLVLDHKTLELLNN 1153

  Fly   603 LKYLNIDK 610
            ::...||:
Human  1154 IRCFKIDQ 1161

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sur-8	NP_001262665.1	leucine-rich repeat	163..184	CDD:275380	6/20 (30%)
		leucine-rich repeat	185..207	CDD:275380	6/21 (29%)
		LRR_RI	204..401	CDD:238064	66/261 (25%)
		LRR_8	207..264	CDD:290566	22/80 (28%)
		leucine-rich repeat	208..230	CDD:275380	9/21 (43%)
		leucine-rich repeat	231..253	CDD:275380	8/21 (38%)
		LRR_8	252..310	CDD:290566	23/122 (19%)
		leucine-rich repeat	254..276	CDD:275380	8/46 (17%)
		leucine-rich repeat	277..299	CDD:275380	9/52 (17%)
		LRR_8	299..356	CDD:290566	19/65 (29%)
		leucine-rich repeat	300..322	CDD:275380	9/21 (43%)
		leucine-rich repeat	323..345	CDD:275380	6/21 (29%)
		LRR_8	344..403	CDD:290566	16/58 (28%)
		leucine-rich repeat	346..368	CDD:275380	6/21 (29%)
		leucine-rich repeat	369..392	CDD:275380	5/22 (23%)
		LRR_RI	<379..566	CDD:238064	55/189 (29%)
		leucine-rich repeat	417..440	CDD:275380	3/22 (14%)
		leucine-rich repeat	441..486	CDD:275380	16/47 (34%)
		LRR_8	463..520	CDD:290566	22/57 (39%)
		leucine-rich repeat	487..507	CDD:275380	11/19 (58%)
		leucine-rich repeat	510..532	CDD:275380	7/21 (33%)
		LRR_8	532..588	CDD:290566	10/55 (18%)
		leucine-rich repeat	556..578	CDD:275380	5/21 (24%)
		leucine-rich repeat	603..626	CDD:275380	2/8 (25%)
PHLPP1	NP_919431.2	leucine-rich repeat	1107..1129	CDD:275380	7/38 (18%)
		PP2Cc	1168..1420	CDD:214625
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1458..1510
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1673..1717
		PDZ-binding, required for interaction with SLC9A3R1. /evidence=ECO:0000269\|PubMed:21804599	1715..1717
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..118
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..156
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..470
		PH_PHLPP-like	535..631	CDD:270131
		PH	555..636	CDD:278594
		LRR_RI	625..929	CDD:238064	65/246 (26%)
		LRR_8	638..703	CDD:290566	7/20 (35%)
		LRR 1	638..659
		leucine-rich repeat	641..661	CDD:275380
		LRR 2	661..682
		leucine-rich repeat	662..692	CDD:275380	3/7 (43%)
		LRR 3	692..712		6/21 (29%)
		leucine-rich repeat	693..738	CDD:275380	12/44 (27%)
		LRR_8	714..770	CDD:290566	19/55 (35%)
		LRR 4	715..736		6/20 (30%)
		LRR 5	738..760		9/21 (43%)
		leucine-rich repeat	739..761	CDD:275380	9/21 (43%)
		LRR 6	761..783		8/21 (38%)
		leucine-rich repeat	762..784	CDD:275380	8/21 (38%)
		LRR 7	784..804		1/19 (5%)
		leucine-rich repeat	785..808	CDD:275380	1/22 (5%)
		LRR 8	808..831		6/22 (27%)
		leucine-rich repeat	810..832	CDD:275380	7/21 (33%)
		LRR_RI	814..1074	CDD:238064	77/283 (27%)
		LRR 9	832..853		8/20 (40%)
		leucine-rich repeat	833..853	CDD:275380	8/19 (42%)
		leucine-rich repeat	854..895	CDD:275380	2/40 (5%)
		LRR 10	873..894		2/20 (10%)
		LRR 11	895..916		9/20 (45%)
		leucine-rich repeat	896..918	CDD:275380	9/21 (43%)
		LRR 12	918..939		6/20 (30%)
		leucine-rich repeat	919..941	CDD:275380	6/21 (29%)
		LRR 13	941..962		7/21 (33%)
		leucine-rich repeat	942..963	CDD:275380	6/21 (29%)
		LRR_8	962..1024	CDD:290566	19/83 (23%)
		LRR 14	963..984		6/20 (30%)
		leucine-rich repeat	964..987	CDD:275380	5/22 (23%)
		LRR 15	987..1008		7/29 (24%)
		leucine-rich repeat	988..1011	CDD:275380	8/31 (26%)
		LRR 16	1013..1033		8/32 (25%)
		LRR_8	1014..1072	CDD:290566	21/58 (36%)
		leucine-rich repeat	1014..1037	CDD:275380	8/23 (35%)
		LRR 17	1037..1058		7/20 (35%)
		leucine-rich repeat	1038..1061	CDD:275380	8/22 (36%)
		LRR 18	1061..1082		11/20 (55%)
		Interaction with SLC9A3R1. /evidence=ECO:0000269\|PubMed:21804599	1076..1205		30/110 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9772
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940