DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sur-8 and PHLPP2

DIOPT Version :9

Sequence 1:	NP_001262665.1	Gene:	Sur-8 / 42093	FlyBaseID:	FBgn0038504	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_055835.2	Gene:	PHLPP2 / 23035	HGNCID:	29149	Length:	1323	Species:	Homo sapiens

Alignment Length:	524	Identity:	143/524 - (27%)
Similarity:	228/524 - (43%)	Gaps:	120/524 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 IKRLDLSKSSITVIPSTVKECVHLTELYLYSNKIGQLPPEIGCLVSLRNLALNENSLTSLPESLQ 226
            :|.|:||.:.:.:.|..:.|...||||.|..|....||.:||.|::|:.|.|:.|.||:|||.|.
Human   301 LKGLNLSHNKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELG 365

  Fly   227 NCSQLKVLDLRHNKLAEIPPVIYRL---------------------------------------- 251
            |..||..|.:..|..::||.|..:|
Human   366 NLQQLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTM 430

  Fly   252 --------RSLTTLYLRFNRITAVADDLRQLVNLTMLSLRENKIREL---GSAIGAL-------- 297
                    :.:|.:.||.||:|.:  ||..|.:|..|....|::|||   |.::..|
Human   431 VIENLEGNKHITHVDLRDNRLTDL--DLSSLCSLEQLHCGRNQLRELTLSGFSLRTLYASSNRLT 493

  Fly   298 -VN-------LTTLDVSHNHLEHLPEDIGNCVNLSALDLQHNELLDIPDSIGNLKSLVRLGMRYN 354
             ||       ||.||:|.|.||.:|:.......:..||:.:|.|.::|..|.:..||.:|.:.:|
Human   494 AVNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHN 558

  Fly   355 RLSSVPATLKNCKSMDEFNVEGNGITQLPDGMLASLSGLTTITLSRNQFASYPTGGPAQFTNVYS 419
            .:.::| ||.....::..:::.|.:|:|||.:.:....|..:..|.|...|.|:.    .|...|
Human   559 HVQNLP-TLVEHIPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSA----CTGEES 618

  Fly   420 INLEHNRIDKIPYGIFSRAKGLTKLNMKENMLT--ALPLDIGTWVNMVELNLATNALQKLPDDIM 482
            :::                  |..|.:..|:||  .:|:.:| .:::..|:||.|.||..|...:
Human   619 LSM------------------LQLLYLTNNLLTDQCIPVLVG-HLHLRILHLANNQLQTFPASKL 664

  Fly   483 N-LQNLEILILSNNMLKKIPNTIGNLRKLRILDLEENRIEVLPHEIGLLHELQRLILQTNQITML 546
            | |:.||.|.||.|.||.||.||.|.::|..|....|.|.:.| ||..|.::|.:.|..|.:|.:
Human   665 NKLEQLEELNLSGNKLKTIPTTIANCKRLHTLVAHSNNISIFP-EILQLPQIQFVDLSCNDLTEI 728

  Fly   547 PRSIGHLGNLTHLSVSENNLQFLPEEIGSLESLENLYINQNPGLEKLPFELALCQNLKYLNIDKC 611
                                 .:||.:.:  :|::|.:..|..|......|.:..::..|.||:.
Human   729 ---------------------LIPEALPA--TLQDLDLTGNTNLVLEHKTLDIFSHITTLKIDQK 770

  Fly   612 PLST 615
            ||.|
Human   771 PLPT 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sur-8	NP_001262665.1	leucine-rich repeat	163..184	CDD:275380	6/20 (30%)
		leucine-rich repeat	185..207	CDD:275380	11/21 (52%)
		LRR_RI	204..401	CDD:238064	68/263 (26%)
		LRR_8	207..264	CDD:290566	23/104 (22%)
		leucine-rich repeat	208..230	CDD:275380	11/21 (52%)
		leucine-rich repeat	231..253	CDD:275380	7/69 (10%)
		LRR_8	252..310	CDD:290566	25/76 (33%)
		leucine-rich repeat	254..276	CDD:275380	9/21 (43%)
		leucine-rich repeat	277..299	CDD:275380	8/33 (24%)
		LRR_8	299..356	CDD:290566	20/63 (32%)
		leucine-rich repeat	300..322	CDD:275380	9/21 (43%)
		leucine-rich repeat	323..345	CDD:275380	6/21 (29%)
		LRR_8	344..403	CDD:290566	15/58 (26%)
		leucine-rich repeat	346..368	CDD:275380	6/21 (29%)
		leucine-rich repeat	369..392	CDD:275380	5/22 (23%)
		LRR_RI	<379..566	CDD:238064	52/189 (28%)
		leucine-rich repeat	417..440	CDD:275380	1/22 (5%)
		leucine-rich repeat	441..486	CDD:275380	16/47 (34%)
		LRR_8	463..520	CDD:290566	25/57 (44%)
		leucine-rich repeat	487..507	CDD:275380	12/19 (63%)
		leucine-rich repeat	510..532	CDD:275380	8/21 (38%)
		LRR_8	532..588	CDD:290566	8/55 (15%)
		leucine-rich repeat	556..578	CDD:275380	2/21 (10%)
		leucine-rich repeat	603..626	CDD:275380	6/13 (46%)
PHLPP2	NP_055835.2	PH_PHLPP-like	149..243	CDD:270131
		LRR 1	250..271
		leucine-rich repeat	253..273	CDD:275380
		LRR 2	273..296
		leucine-rich repeat	274..300	CDD:275380
		LRR 3	300..321		5/19 (26%)
		leucine-rich repeat	301..323	CDD:275380	6/21 (29%)
		LRR_RI	313..606	CDD:238064	81/295 (27%)
		LRR_8	322..380	CDD:290566	26/57 (46%)
		LRR 4	323..344		10/20 (50%)
		leucine-rich repeat	324..346	CDD:275380	11/21 (52%)
		LRR 5	346..368		11/21 (52%)
		leucine-rich repeat	347..369	CDD:275380	11/21 (52%)
		LRR 6	369..390		7/20 (35%)
		leucine-rich repeat	370..416	CDD:275380	7/45 (16%)
		LRR 7	392..412		0/19 (0%)
		LRR 8	416..439		0/22 (0%)
		leucine-rich repeat	418..440	CDD:275380	0/21 (0%)
		LRR 9	440..460		8/21 (38%)
		leucine-rich repeat	442..461	CDD:275380	9/20 (45%)
		LRR 10	461..480		6/18 (33%)
		leucine-rich repeat	462..481	CDD:275380	7/18 (39%)
		LRR 11	481..502		3/20 (15%)
		leucine-rich repeat	482..503	CDD:275380	3/20 (15%)
		LRR 12	503..524		9/20 (45%)
		leucine-rich repeat	504..526	CDD:275380	9/21 (43%)
		LRR 13	526..547		6/20 (30%)
		leucine-rich repeat	527..549	CDD:275380	6/21 (29%)
		LRR_8	549..606	CDD:290566	15/57 (26%)
		LRR 14	549..570		7/21 (33%)
		leucine-rich repeat	550..565	CDD:275380	4/15 (27%)
		LRR 15	571..592		5/20 (25%)
		leucine-rich repeat	572..595	CDD:275380	5/22 (23%)
		LRR 16	595..616		6/24 (25%)
		leucine-rich repeat	596..645	CDD:275380	14/71 (20%)
		LRR 17	621..644		7/41 (17%)
		LRR_8	645..703	CDD:290566	25/57 (44%)
		LRR_4	645..685	CDD:289563	18/39 (46%)
		LRR 18	645..666		7/20 (35%)
		leucine-rich repeat	646..669	CDD:275380	9/22 (41%)
		LRR 19	669..690		12/20 (60%)
		leucine-rich repeat	670..692	CDD:275380	13/21 (62%)
		LRR 20	692..713		7/21 (33%)
		leucine-rich repeat	693..714	CDD:275380	8/21 (38%)
		LRR 21	714..735		6/41 (15%)
		leucine-rich repeat	715..734	CDD:275380	6/39 (15%)
		LRR 22	737..758		5/20 (25%)
		leucine-rich repeat	738..764	CDD:275380	5/25 (20%)
		PP2Cc	784..1033	CDD:238083
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1060..1157
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1285..1323
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9772
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940