DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sur-8 and Lrch2

DIOPT Version :10

Sequence 1:NP_001262665.1 Gene:Sur-8 / 42093 FlyBaseID:FBgn0038504 Length:694 Species:Drosophila melanogaster
Sequence 2:NP_001390505.1 Gene:Lrch2 / 210297 MGIID:2147870 Length:799 Species:Mus musculus


Alignment Length:477 Identity:111/477 - (23%)
Similarity:187/477 - (39%) Gaps:124/477 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 GGVPGGGAEGGGGSGNSGGGGKTSNGSAEAPTLCFAGGSGTAGAIAGTEELSNANSPANGAGGAT 89
            ||..|||:.||||:...||||.             .||.|.|||               |.||..
Mouse    14 GGCSGGGSGGGGGAAGGGGGGG-------------GGGGGGAGA---------------GGGGGC 50

  Fly    90 GSTGSGQQPTGSNGHSHLHNENNANMPPETRPKMVTVKHPESNKPKPTTKKSKPIQADQDVIKAL 154
            |.|.:...|..:     |..:...|.|.         .||.|.:|:.|.:         .:.:||
Mouse    51 GGTVAVPIPVPT-----LFGQPFPNGPQ---------WHPGSLQPQHTVR---------SLDRAL 92

  Fly   155 QRCRDEGIKRLDLSKSSITVIPSTVKECVHLTELYLYSNKIGQLPPEIGCLVSLRNLALNENSLT 219
            :...:.||  |.||...:...|.:..:....|:..|..|:..::|.::.....|..|.|..|.:.
Mouse    93 EEAGNSGI--LSLSGRKLREFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIK 155

  Fly   220 SLPESLQNCSQLKVLDLRHNKLAEIPPVIYRLRSLTTLYLRFNRITAVADDLRQLVNLTMLSLRE 284
            ::||:::|...|..|::..|.|:.:|..::.|                        .|.:|.:..
Mouse   156 TIPEAIKNLQMLTYLNISRNLLSTLPKYLFDL------------------------PLKVLVVSN 196

  Fly   285 NKIRELGSAIGALVNLTTLDVSHNHLEHLPEDIGNCVNLSALDLQHNELLDIPDSIGNLKSLVRL 349
            ||:..:...||.|.:|..||||.|.::.||:.:|...:|..|:::.|.|..:||.:|:| .||:|
Mouse   197 NKLVSIPEEIGKLKDLMELDVSCNEIQVLPQQMGKLHSLKELNIRRNNLHVLPDELGDL-PLVKL 260

  Fly   350 GMRYNRLSSVPATLKNCKSMDEFNVEGNGITQLPDGMLASLSGLTTITLSRNQFASYPTGGPAQF 414
            ....|:::.:|...:....:....::.|.: |:|...:. |.|...|               .::
Mouse   261 DFSCNKVTEIPVCYRKLHHLQVIILDNNPL-QVPPAQIC-LKGKVHI---------------FKY 308

  Fly   415 TNVYSINLEHNRIDKIPYGIFSRAKGLTKLNMKENMLTALPL---------------DIGTWVNM 464
            .|:.:.    .|:||.|..:     .|..||.:   :.:.||               |.|...:.
Mouse   309 LNIQAC----CRMDKKPDSL-----DLPSLNKR---MPSQPLTDSMEDFYPNKNHGPDSGIGSDN 361

  Fly   465 VELNLATNALQKLPDDIMNLQN 486
            .|..|:|.  :...||.::|.:
Mouse   362 GEKRLSTT--EPSDDDTISLHS 381

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sur-8NP_001262665.1 leucine-rich repeat 163..184 CDD:275380 4/20 (20%)
LRR 185..535 CDD:443914 70/317 (22%)
leucine-rich repeat 185..207 CDD:275380 4/21 (19%)
leucine-rich repeat 208..230 CDD:275380 7/21 (33%)
leucine-rich repeat 231..253 CDD:275380 6/21 (29%)
leucine-rich repeat 254..276 CDD:275380 0/21 (0%)
leucine-rich repeat 277..299 CDD:275380 7/21 (33%)
leucine-rich repeat 300..322 CDD:275380 9/21 (43%)
leucine-rich repeat 323..345 CDD:275380 8/21 (38%)
leucine-rich repeat 346..368 CDD:275380 5/21 (24%)
leucine-rich repeat 369..392 CDD:275380 4/22 (18%)
leucine-rich repeat 417..440 CDD:275380 4/22 (18%)
leucine-rich repeat 441..486 CDD:275380 13/59 (22%)
PPP1R42 472..617 CDD:455733 3/15 (20%)
leucine-rich repeat 487..507 CDD:275380 111/477 (23%)
leucine-rich repeat 510..532 CDD:275380
leucine-rich repeat 556..578 CDD:275380
leucine-rich repeat 603..626 CDD:275380
Lrch2NP_001390505.1 LRR <87..>291 CDD:443914 55/231 (24%)
leucine-rich repeat 100..120 CDD:275380 5/21 (24%)
leucine-rich repeat 121..143 CDD:275380 4/21 (19%)
leucine-rich repeat 144..166 CDD:275380 7/21 (33%)
leucine-rich repeat 167..182 CDD:275380 4/14 (29%)
leucine-rich repeat 189..211 CDD:275380 7/21 (33%)
leucine-rich repeat 212..234 CDD:275380 9/21 (43%)
leucine-rich repeat 235..255 CDD:275380 7/19 (37%)
leucine-rich repeat 257..279 CDD:275380 5/21 (24%)
leucine-rich repeat 280..298 CDD:275380 3/18 (17%)
CH_LRCH2 677..787 CDD:409120
Blue background indicates that the domain is not in the aligned region.

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