DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sur-8 and phlp-2

DIOPT Version :9

Sequence 1:	NP_001262665.1	Gene:	Sur-8 / 42093	FlyBaseID:	FBgn0038504	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_001337270.1	Gene:	phlp-2 / 185690	WormBaseID:	WBGene00009647	Length:	1126	Species:	Caenorhabditis elegans

Alignment Length:	644	Identity:	155/644 - (24%)
Similarity:	259/644 - (40%)	Gaps:	154/644 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 QQPTGSNGHSHLHNENNANMPP-----ETRPKMVTVKHPESNKPKPTTKKSKPIQADQDVIKALQ 155
            ||...|| |....:|....:|.     |.|.:::.::........||.|...|:....|:.
Worm   225 QQVEKSN-HVDASDEQLTLIPEQILNNEARVQILNLRRNSLISRPPTEKSMAPLGYIDDLY---- 284

  Fly   156 RCRDEGIKRLDLSKSSITVIPSTVKECVHLTELYLYSNKIGQLPPEIGCLVSLRNLALNENSLTS 220
              |...::.:|||.:.|...|..:....||.:|.|.||.|..:|.|...:..|:.|.|:.|.|.:
Worm   285 --RVHSLQVIDLSANQILSFPIQLTLLSHLRQLNLSSNYISSVPSECSNMRRLQYLNLSNNQLDT 347

  Fly   221 LPESLQNCSQLKVLDLRHNKLAEIPPVIYRLRSLTTLYL------RFNRITAVAD------DLRQ 273
            ||:|:.....|:.||:..|:.::|||.::.|    ||.:      ...:|..|.:      |||:
Worm   348 LPDSISELQNLQSLDISFNQFSQIPPCLFHL----TLEMWRLAGNNIEKIDRVGEMQIQKIDLRR 408

  Fly   274 LV----------NLTMLSLRENKI-------------------RELGS----------------A 293
            .|          |:|.|.||:|.:                   .:|.|                .
Worm   409 NVLDTSFRLDIENITHLDLRDNSMISTVHLTNLRFLKVIHCERLQLSSLHLSGESLTHVYADHNL 473

  Fly   294 IGALV------NLTTLDVSHNHLEHLPEDIGNCVNLSALDLQHNELLDIPDSIGNLKSLVRLGMR 352
            :.:||      ||.||.:|.||..:||:.|.:|.||:.|...:|.|:.:|:.|...:||..:...
Worm   474 LDSLVVMPLPQNLQTLSLSFNHFRNLPDWISDCPNLTFLRANNNSLVALPERIFYSQSLRSIFAF 538

  Fly   353 YNRLSSVPATLKNCKSMDEFNVEGNGITQLPDGMLASLSGLTTITLSRNQFASYPTGGPAQFTNV 417
            .|.:..:|          :|..|               :.|.|:.|.:|:.:|.|
Worm   539 INEIEHIP----------DFGEE---------------NCLETLILYKNKLSSLP---------- 568

  Fly   418 YSINLEHNRIDKIPYGIFSRAKGLTKLNMKENMLTALP-LDIGTWVNMVELNLATNAL--QKLPD 479
                 :|         .||....|.:||:..|.:..|| .|..::..:..|..|.|.|  ..:|
Worm   569 -----KH---------FFSILPRLRQLNISSNFIELLPYFDGSSFCRLQILRCANNYLTENSVP- 618

  Fly   480 DIMNLQNLEILILSNNMLKKIPNT-IGNLRKLRILDLEENRIEVLPHEIGLLHELQRLILQTNQI 543
            .|:|:::|:|:.||:|.|....:: :.:|..|..|:|..||:..|...:.||..||.|...:||:
Worm   619 VIVNMKHLKIIDLSHNRLNSFDDSALSSLELLEDLNLSSNRLTRLADCLALLPCLQVLRAHSNQL 683

  Fly   544 TMLPRSIGHLGNLTH-LSVSENNLQFLPEEIGSLE-----SLENLYINQNPG---LEKLPFELAL 599
            ..:|..  ...|..| :.||.||:     .:|:|:     :|.:..:..|.|   .|..|....:
Worm   684 VHVPEF--RASNQLHTIDVSSNNI-----SLGTLQFKAPPNLRHFDVTCNSGDFDTENFPENAKM 741

  Fly   600 CQNLKYLNIDKCPLSTIPPEIQAGGPSLVLQWLKMHSPYRQMXDVDGVWRTVYVGSDCY 658
            ...:..:||.:...:....:|...|.    :.:|.....||:  |:..:..:..||:.|
Worm   742 HSKMNTINISEGSQNLFGFQIGVSGS----RGMKNKQCIRQVR-VENTFGFIDGGSNSY 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sur-8	NP_001262665.1	leucine-rich repeat	163..184	CDD:275380	5/20 (25%)
		leucine-rich repeat	185..207	CDD:275380	8/21 (38%)
		LRR_RI	204..401	CDD:238064	61/259 (24%)
		LRR_8	207..264	CDD:290566	18/62 (29%)
		leucine-rich repeat	208..230	CDD:275380	8/21 (38%)
		leucine-rich repeat	231..253	CDD:275380	8/21 (38%)
		LRR_8	252..310	CDD:290566	24/120 (20%)
		leucine-rich repeat	254..276	CDD:275380	8/43 (19%)
		leucine-rich repeat	277..299	CDD:275380	9/62 (15%)
		LRR_8	299..356	CDD:290566	21/56 (38%)
		leucine-rich repeat	300..322	CDD:275380	10/21 (48%)
		leucine-rich repeat	323..345	CDD:275380	6/21 (29%)
		LRR_8	344..403	CDD:290566	10/58 (17%)
		leucine-rich repeat	346..368	CDD:275380	3/21 (14%)
		leucine-rich repeat	369..392	CDD:275380	2/22 (9%)
		LRR_RI	<379..566	CDD:238064	49/191 (26%)
		leucine-rich repeat	417..440	CDD:275380	3/22 (14%)
		leucine-rich repeat	441..486	CDD:275380	14/47 (30%)
		LRR_8	463..520	CDD:290566	18/59 (31%)
		leucine-rich repeat	487..507	CDD:275380	6/20 (30%)
		leucine-rich repeat	510..532	CDD:275380	8/21 (38%)
		LRR_8	532..588	CDD:290566	15/61 (25%)
		leucine-rich repeat	556..578	CDD:275380	7/27 (26%)
		leucine-rich repeat	603..626	CDD:275380	4/22 (18%)
phlp-2	NP_001337270.1	leucine-rich repeat	232..253	CDD:275380	4/20 (20%)
		leucine-rich repeat	254..288	CDD:275380	6/39 (15%)
		PLN00113	283..>718	CDD:331614	125/501 (25%)
		leucine-rich repeat	289..311	CDD:275380	5/21 (24%)
		leucine-rich repeat	312..334	CDD:275380	8/21 (38%)
		leucine-rich repeat	335..357	CDD:275380	8/21 (38%)
		leucine-rich repeat	358..379	CDD:275380	8/24 (33%)
		leucine-rich repeat	380..440	CDD:275380	13/59 (22%)
		leucine-rich repeat	441..485	CDD:275380	4/43 (9%)
		leucine-rich repeat	486..508	CDD:275380	10/21 (48%)
		leucine-rich repeat	509..534	CDD:275380	8/24 (33%)
		leucine-rich repeat	554..577	CDD:275380	9/46 (20%)
		leucine-rich repeat	578..602	CDD:275380	7/23 (30%)
		leucine-rich repeat	603..625	CDD:275380	7/22 (32%)
		leucine-rich repeat	626..649	CDD:275380	7/22 (32%)
		leucine-rich repeat	650..672	CDD:275380	8/21 (38%)
		leucine-rich repeat	673..694	CDD:275380	6/22 (27%)
		PP2Cc	754..985	CDD:214625	9/47 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9772
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940