Protein Alignment Sur-8 and soc-2

DIOPT Version :10

• Sequence 1: NP_001262665.1
• Gene: Sur-8 / 42093
• FlyBaseID: FBgn0038504
• Length: 694
• Species: Drosophila melanogaster
• Sequence 2: NP_001293758.1
• Gene: soc-2 / 177286
• WormBaseID: WBGene00004929
• Length: 631
• Species: Caenorhabditis elegans
• Alignment Length: 642
• Identity: 309/642 - (48%)
• Similarity: 413/642 - (64%)
• Gaps: 72/642 - (11%)

  Fly    35 GGGSGNSGGGGKTSNGSAEAPTLCFAGGSGTAGAIAGTEELSNAN-SPANGAGGATGSTGSGQQP 98
            ||.|..|..|..:|:|    ||       ...|.||.:.:.:... |..:|||        ||.|
 Worm    18 GGSSSTSAPGSASSSG----PT-------KRRGRIAASIDSARRRLSLQHGAG--------GQDP 63

  Fly    99 TGSNGHSHLHN--------ENNANMPP-----ETRP----------KMVTV-------------K 127
            .      ||.:        ..|.::|.     ||.|          |.|:|             |
 Worm    64 V------HLQSIALRGRGKSENGSLPDLIEKRETPPTTANTGVSATKRVSVIATDRDRAYFLRQK 122

  Fly   128 HPESNKPKPTTKKSKPIQADQDVIKALQRCRDEGIKRLDLSKSSITVIPSTVKECVHLTELYLYS 192
            :..:||.          .|::|::|...:|::...:|||||...||.|||.:||...||||:||.
 Worm   123 NMRNNKG----------HAEKDLLKEFHKCKEAQDQRLDLSSIEITSIPSPIKELTQLTELFLYK 177

  Fly   193 NKIGQLPPEIGCLVSLRNLALNENSLTSLPESLQNCSQLKVLDLRHNKLAEIPPVIYRLRSLTTL 257
            ||:..||.|||.||:|:.|.|:||:|||||:||.:...|:.||||||||.|:|.|||::.||.||
 Worm   178 NKLTCLPTEIGQLVNLKKLGLSENALTSLPDSLASLESLETLDLRHNKLTEVPSVIYKIGSLETL 242

  Fly   258 YLRFNRITAVADDLRQLVNLTMLSLRENKIRELGSAIGALVNLTTLDVSHNHLEHLPEDIGNCVN 322
            :||:|||.||.:.:..|..|.||.:||||||||.||||.|.:|....||:|||..:||:||:|.:
 Worm   243 WLRYNRIVAVDEQIGNLSKLKMLDVRENKIRELPSAIGKLTSLVVCLVSYNHLTRVPEEIGDCHS 307

  Fly   323 LSALDLQHNELLDIPDSIGNLKSLVRLGMRYNRLSSVPATLKNCKSMDEFNVEGNGITQLPDGML 387
            |:.||||||:|.::|.|||.|.:|||:|:|||::..:|:.|::|:.::||.||.|.:..||..:|
 Worm   308 LTQLDLQHNDLSELPYSIGKLVNLVRIGIRYNKIRCIPSELESCQQLEEFIVESNHLQLLPPNLL 372

  Fly   388 ASLSGLTTITLSRNQFASYPTGGPAQFTNVYSINLEHNRIDKIPYGIFSRAKGLTKLNMKENMLT 452
            ..|..:.|:.||||:..::|.|||.||.:..:||:|||:|.|||.||||:|..|||||:|||.|.
 Worm   373 TMLPKIHTVNLSRNELTAFPAGGPQQFVSTVTINMEHNQISKIPIGIFSKATRLTKLNLKENELV 437

  Fly   453 ALPLDIGTWVNMVELNLATNALQKLPDDIMNLQNLEILILSNNMLKKIPNTIGNLRKLRILDLEE 517
            :||||:|:|.::.||||:||.|:.||:||..|.|||||:||||.|||:||.||||.|||.|||||
 Worm   438 SLPLDMGSWTSITELNLSTNQLKVLPEDIEKLVNLEILVLSNNQLKKLPNQIGNLNKLRELDLEE 502

  Fly   518 NRIEVLPHEIGLLHELQRLILQTNQITMLPRSIGHLGNLTHLSVSENNLQFLPEEIGSLESLENL 582
            |.:|.:|.|||.|..|.:|.:|:|:|..||||||:|.:|..|.:.||||..:|||||.|:||::|
 Worm   503 NELETVPTEIGFLQHLTKLWVQSNKILTLPRSIGNLCSLQDLRLGENNLTAIPEEIGHLDSLKSL 567

  Fly   583 YINQNPGLEKLPFELALCQNLKYLNIDKCPLSTIPPEIQAGGPSLVLQWLKMHSPYR 639
            |:|.|..|..|||||||||:|:.::|:..|||.|||||.|||||||:|:|||..|||
 Worm   568 YLNDNSSLHNLPFELALCQSLEIMSIENSPLSQIPPEITAGGPSLVIQYLKMQGPYR 624

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur-8	NP_001262665.1	leucine-rich repeat	163..184	CDD:275380	12/20 (60%)
		LRR	185..535	CDD:443914	198/349 (57%)
		leucine-rich repeat	185..207	CDD:275380	14/21 (67%)
		leucine-rich repeat	208..230	CDD:275380	12/21 (57%)
		leucine-rich repeat	231..253	CDD:275380	14/21 (67%)
		leucine-rich repeat	254..276	CDD:275380	11/21 (52%)
		leucine-rich repeat	277..299	CDD:275380	16/21 (76%)
		leucine-rich repeat	300..322	CDD:275380	11/21 (52%)
		leucine-rich repeat	323..345	CDD:275380	13/21 (62%)
		leucine-rich repeat	346..368	CDD:275380	10/21 (48%)
		leucine-rich repeat	369..392	CDD:275380	9/22 (41%)
		leucine-rich repeat	417..440	CDD:275380	14/22 (64%)
		leucine-rich repeat	441..486	CDD:275380	27/44 (61%)
		PPP1R42	472..617	CDD:455733	85/144 (59%)
		leucine-rich repeat	487..507	CDD:275380	15/19 (79%)
		leucine-rich repeat	510..532	CDD:275380	14/21 (67%)
		leucine-rich repeat	556..578	CDD:275380	12/21 (57%)
		leucine-rich repeat	603..626	CDD:275380	13/22 (59%)
soc-2	NP_001293758.1	LRR	147..493	CDD:443914	193/345 (56%)
		leucine-rich repeat	148..169	CDD:275380	12/20 (60%)
		leucine-rich repeat	170..192	CDD:275380	14/21 (67%)
		leucine-rich repeat	193..215	CDD:275380	12/21 (57%)
		leucine-rich repeat	216..238	CDD:275380	14/21 (67%)
		leucine-rich repeat	239..261	CDD:275380	11/21 (52%)
		leucine-rich repeat	262..284	CDD:275380	16/21 (76%)
		leucine-rich repeat	285..307	CDD:275380	11/21 (52%)
		leucine-rich repeat	308..330	CDD:275380	13/21 (62%)
		leucine-rich repeat	331..353	CDD:275380	10/21 (48%)
		leucine-rich repeat	354..375	CDD:275380	8/20 (40%)
		leucine-rich repeat	402..425	CDD:275380	14/22 (64%)
		LRR	410..>604	CDD:443914	117/193 (61%)
		leucine-rich repeat	449..471	CDD:275380	12/21 (57%)
		leucine-rich repeat	472..517	CDD:275380	32/44 (73%)
		leucine-rich repeat	541..563	CDD:275380	12/21 (57%)
		leucine-rich repeat	588..611	CDD:275380	13/22 (59%)