DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sur-8 and Lrrc8c

DIOPT Version :10

Sequence 1:NP_001262665.1 Gene:Sur-8 / 42093 FlyBaseID:FBgn0038504 Length:694 Species:Drosophila melanogaster
Sequence 2:NP_598658.1 Gene:Lrrc8c / 100604 MGIID:2140839 Length:803 Species:Mus musculus


Alignment Length:526 Identity:135/526 - (25%)
Similarity:219/526 - (41%) Gaps:145/526 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   109 NENNANMPPETRPKMVTVKHPESNKPKPTTKKSKPIQADQDVIKALQRCRDEGIKRLDLSKSSIT 173
            |.||...|.:.|.|:.|..|                                  .||:|....::
Mouse   404 NLNNEWTPDKLRQKLQTNAH----------------------------------NRLELPLIMLS 434

  Fly   174 VIPSTVKECVHLTELYLYSNKIGQLPPEIGCLVSLRNLALNENS-------LTSLPESLQNCSQL 231
            .:|.||.|...|..|.|...|...:|..|..|.:|:.|.|::.|       |:.|.|:      |
Mouse   435 GLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELCLHQCSVKIHSAALSFLKEN------L 493

  Fly   232 KVLDLRHNKLAEIPPVIYRLRSLTTLYLRFNRITAVADDLRQLVNLTMLSLRENKIRELGSAIGA 296
            |||.::.:.:.|:||.:|.||:|..|||                                  :|:
Mouse   494 KVLSVKFDDMRELPPWMYGLRNLEELYL----------------------------------VGS 524

  Fly   297 LVNLTTLDVSHNHLEHLPEDIGNCVNLSALDLQHNELLDIPDSIGNLKSLVRLGMRYNRLSSVPA 361
            |        ||        ||...|.|              :|:.:||||..|.::.| :|.:|.
Mouse   525 L--------SH--------DISKNVTL--------------ESLRDLKSLKILSIKSN-VSKIPQ 558

  Fly   362 TLKNCKS-MDEFNVEGNGITQLPDGMLASLSGLTTITLSRNQFASYPTGGPAQFTNVYSINLEHN 425
            .:.:..| :.:..|..:| |:|.  ||.:|..:|.:|                     .:.|.|.
Mouse   559 AVVDVSSHLQKMCVHNDG-TKLV--MLNNLKKMTNLT---------------------ELELVHC 599

  Fly   426 RIDKIPYGIFSRAKGLTKLNMKENMLTALPLDIGTWVN---MVELNLATNALQKLPDDIMNLQNL 487
            .:::||:.:|| ...|.:|::|||.|.::. :|.::.:   :..|.|..|::..:|:.|..|.:|
Mouse   600 DLERIPHAVFS-LLSLQELDLKENNLKSIE-EIVSFQHLRKLTVLKLWYNSIAYIPEHIKKLTSL 662

  Fly   488 EILILSNNMLKKIPNTIGNLRKLRILDLEENRIEVLPHEIGLLHELQRLILQTNQITMLPRSIGH 552
            |.|..|:|.::.:|:.:....|:|.|||..|.|..:|.|||:|..||...:..|::..||..:..
Mouse   663 ERLFFSHNKVEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYF 727

  Fly   553 LGNLTHLSVSENNLQFLPEEIGSLESLENLYINQNPGLEKLPFELALCQNLKY--LNIDKCPLST 615
            ...|..|.:.:|:|..|..:||:|..|..|.|..| ..|.||.||..|:.||.  |.::.....|
Mouse   728 CKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDIKGN-HFEVLPPELGDCRALKRAGLVVEDALFET 791

  Fly   616 IPPEIQ 621
            :|.:::
Mouse   792 LPSDVR 797

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sur-8NP_001262665.1 leucine-rich repeat 163..184 CDD:275380 7/20 (35%)
LRR 185..535 CDD:443914 93/360 (26%)
leucine-rich repeat 185..207 CDD:275380 7/21 (33%)
leucine-rich repeat 208..230 CDD:275380 7/28 (25%)
leucine-rich repeat 231..253 CDD:275380 9/21 (43%)
leucine-rich repeat 254..276 CDD:275380 4/21 (19%)
leucine-rich repeat 277..299 CDD:275380 2/21 (10%)
leucine-rich repeat 300..322 CDD:275380 4/21 (19%)
leucine-rich repeat 323..345 CDD:275380 3/21 (14%)
leucine-rich repeat 346..368 CDD:275380 5/21 (24%)
leucine-rich repeat 369..392 CDD:275380 7/22 (32%)
leucine-rich repeat 417..440 CDD:275380 6/22 (27%)
leucine-rich repeat 441..486 CDD:275380 13/47 (28%)
PPP1R42 472..617 CDD:455733 49/146 (34%)
leucine-rich repeat 487..507 CDD:275380 6/19 (32%)
leucine-rich repeat 510..532 CDD:275380 11/21 (52%)
leucine-rich repeat 556..578 CDD:275380 8/21 (38%)
leucine-rich repeat 603..626 CDD:275380 5/21 (24%)
Lrrc8cNP_598658.1 Pannexin_like 1..338 CDD:463622
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 177..206
LRR 1. /evidence=ECO:0000255, ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK 409..420 3/10 (30%)
LRR 2. /evidence=ECO:0000255, ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK 421..443 7/55 (13%)
LRR 3. /evidence=ECO:0000255, ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK 446..466 6/19 (32%)
LRR 4. /evidence=ECO:0000255, ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK 467..488 5/20 (25%)
LRR 5. /evidence=ECO:0000255, ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK 490..513 9/28 (32%)
leucine-rich repeat 493..515 CDD:275380 9/21 (43%)
PPP1R42 <512..622 CDD:455733 42/199 (21%)
LRR 6. /evidence=ECO:0000255, ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK 515..537 12/85 (14%)
leucine-rich repeat 516..543 CDD:275380 14/90 (16%)
LRR 7. /evidence=ECO:0000255, ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK 541..563 8/22 (36%)
leucine-rich repeat 544..566 CDD:275380 5/22 (23%)
LRR 8. /evidence=ECO:0000255, ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK 566..586 6/22 (27%)
LRR <582..>772 CDD:443914 62/213 (29%)
LRR 9. /evidence=ECO:0000255, ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK 588..611 8/44 (18%)
leucine-rich repeat 591..613 CDD:275380 7/43 (16%)
LRR 10. /evidence=ECO:0000255, ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK 613..635 7/22 (32%)
leucine-rich repeat 614..638 CDD:275380 7/24 (29%)
LRR 11. /evidence=ECO:0000255, ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK 637..659 5/21 (24%)
leucine-rich repeat 639..661 CDD:275380 6/21 (29%)
LRR 12. /evidence=ECO:0000255, ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK 660..682 6/21 (29%)
leucine-rich repeat 662..684 CDD:275380 6/21 (29%)
LRR 13. /evidence=ECO:0000255, ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK 684..705 11/20 (55%)
leucine-rich repeat 685..707 CDD:275380 11/21 (52%)
LRR 14. /evidence=ECO:0000255, ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK 706..728 5/21 (24%)
leucine-rich repeat 708..730 CDD:275380 5/21 (24%)
LRR 15. /evidence=ECO:0000255, ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK 730..751 7/20 (35%)
leucine-rich repeat 731..752 CDD:275380 7/20 (35%)
LRR 16. /evidence=ECO:0000255, ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK 752..774 9/22 (41%)
LRR 17. /evidence=ECO:0000255, ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK 776..799 5/22 (23%)
Blue background indicates that the domain is not in the aligned region.

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