DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sur-8 and Lrriq4

DIOPT Version :9

Sequence 1:	NP_001262665.1	Gene:	Sur-8 / 42093	FlyBaseID:	FBgn0038504	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	XP_038959535.1	Gene:	Lrriq4 / 100363341	RGDID:	2323202	Length:	621	Species:	Rattus norvegicus

Alignment Length:	554	Identity:	158/554 - (28%)
Similarity:	243/554 - (43%)	Gaps:	59/554 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 LDLSKSSITVIPSTVKECVHLTELYLYSNKIGQLPPEIGCLVSLRNLALNENSLTSLPESLQNCS 229
            :|.|..::..||..:.....|.|::|.:|:|.::|..|..|..::.|.|:.|||.:|.:.|.:.|
  Rat    91 IDGSNQNLKTIPPEILALKELEEVHLENNQISEIPQGIQHLEKIKVLYLHNNSLQNLCQELGSLS 155

  Fly   230 QLKVLDLRHNKLA-EIPPVIYRLRSLTTLYLRFNRITAVADDL-RQLVNLTMLSLRENKIRELGS 292
            .|:.|||..|.|. ....||.|||:|..|.|....:|.|...: :.|.:|.:|.|.||.:..|..
  Rat   156 NLESLDLSGNLLVLSSLQVICRLRTLRELRLYNTGLTEVPSGICKSLHHLELLGLSENYLESLPK 220

  Fly   293 AIGALVNLTTLDVSHNHLEHLPEDIGNCVNLSALDLQHNELLDIPDSIGNLKSLVRLGMRYNRLS 357
            .|.....|..:.:..||.|:.|.|:....||..:||..|:|..||:.||:|..|.:..:..|.|.
  Rat   221 EIVNQTKLREIYLKQNHFENFPCDLCVLCNLEVIDLDDNKLKTIPEDIGHLVRLQKFYVASNHLM 285

  Fly   358 SVPATLKNCKSMDEFNVEGNGITQLPDGMLASLSGLTTITLSRNQFASYPTGGPAQFTNVYSINL 422
            .:|.:|.:|:.:...::..|.|..||    .||..||.:|                     .:.|
  Rat   286 GLPESLSHCRKLSVLDLTHNSIHSLP----YSLEQLTELT---------------------EVGL 325

  Fly   423 EHNRIDKIPYGIFSRAKGLTKLNMKENMLTALPLDIGTWVNMVELNLATNALQKLPDDIMNLQNL 487
            ..||::|:| .:......|..|.::...|..|.......||:..|:|:.|.:...|..|..|::|
  Rat   326 SGNRLEKVP-RLLCNWVSLHLLYLRNTSLHGLRRSFKHLVNLRFLDLSQNHIDHFPVQICTLKDL 389

  Fly   488 EILILSNNMLKKIPNTIGNLRKLRILDLEEN--------------------------RIEVLPHE 526
            |||.|.:|.:|::|..|.:|.||:||.|..|                          ::..||..
  Rat   390 EILALDDNKVKQLPPAISSLSKLKILGLTGNDFVSFPEEIFSLVSLEKLYIGQDQGSKLSSLPEN 454

  Fly   527 IGLLHELQRLILQTNQITMLPRSIGHLGNLTHLSVSENNLQFLPEEIGSLESLENLYINQNPGLE 591
            |..|..|:.|.::.||:..||.|:|.:.||..|....|.|:.||:.|.....|..|.:..|. |.
  Rat   455 IKKLTNLKELYIENNQLEQLPASLGLMPNLEVLDCRHNLLRQLPDAICQTRDLRELLLEDNL-LS 518

  Fly   592 KLPFELALCQNLKYLNIDKCPLSTIPPEIQAGGPSLVLQWLKMHSPYRQM-XDVDGVWRTVYVGS 655
            :||..|....|||.|.:....:...|.|:...|...:.:.||.:...:.| ..:...||.:.|..
  Rat   519 RLPENLDHLVNLKVLTLTDNLMEDPPMEVCEQGNEAIWRHLKENRIRKVMATKIQAWWRGIMVRK 583

  Fly   656 DCYYQYE--LQTVNQAPGAGGNGGGGAAAAGGSA 687
            . |..||  |:...:......:..|.||..|..|
  Rat   584 G-YGSYEELLKARKKGKSPPKDKKGKAAPKGKPA 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sur-8	NP_001262665.1	leucine-rich repeat	163..184	CDD:275380	4/18 (22%)
		leucine-rich repeat	185..207	CDD:275380	8/21 (38%)
		LRR_RI	204..401	CDD:238064	65/198 (33%)
		LRR_8	207..264	CDD:290566	22/57 (39%)
		leucine-rich repeat	208..230	CDD:275380	7/21 (33%)
		leucine-rich repeat	231..253	CDD:275380	10/22 (45%)
		LRR_8	252..310	CDD:290566	16/58 (28%)
		leucine-rich repeat	254..276	CDD:275380	6/22 (27%)
		leucine-rich repeat	277..299	CDD:275380	7/21 (33%)
		LRR_8	299..356	CDD:290566	19/56 (34%)
		leucine-rich repeat	300..322	CDD:275380	6/21 (29%)
		leucine-rich repeat	323..345	CDD:275380	10/21 (48%)
		LRR_8	344..403	CDD:290566	15/58 (26%)
		leucine-rich repeat	346..368	CDD:275380	6/21 (29%)
		leucine-rich repeat	369..392	CDD:275380	6/22 (27%)
		LRR_RI	<379..566	CDD:238064	57/212 (27%)
		leucine-rich repeat	417..440	CDD:275380	5/22 (23%)
		leucine-rich repeat	441..486	CDD:275380	12/44 (27%)
		LRR_8	463..520	CDD:290566	23/82 (28%)
		leucine-rich repeat	487..507	CDD:275380	9/19 (47%)
		leucine-rich repeat	510..532	CDD:275380	9/47 (19%)
		LRR_8	532..588	CDD:290566	18/55 (33%)
		leucine-rich repeat	556..578	CDD:275380	7/21 (33%)
		leucine-rich repeat	603..626	CDD:275380	6/22 (27%)
Lrriq4	XP_038959535.1	PLN00113	90..>494	CDD:215061	125/428 (29%)
		leucine-rich repeat	111..133	CDD:275380	8/21 (38%)
		leucine-rich repeat	134..156	CDD:275380	7/21 (33%)
		leucine-rich repeat	157..204	CDD:275380	17/46 (37%)
		leucine-rich repeat	205..250	CDD:275380	13/44 (30%)
		leucine-rich repeat	251..273	CDD:275380	10/21 (48%)
		leucine-rich repeat	274..296	CDD:275380	6/21 (29%)
		leucine-rich repeat	297..319	CDD:275380	7/25 (28%)
		leucine-rich repeat	320..342	CDD:275380	6/43 (14%)
		leucine-rich repeat	343..365	CDD:275380	4/21 (19%)
		leucine-rich repeat	366..388	CDD:275380	6/21 (29%)
		leucine-rich repeat	389..411	CDD:275380	10/21 (48%)
		leucine-rich repeat	412..434	CDD:275380	5/21 (24%)
		leucine-rich repeat	435..460	CDD:275380	4/24 (17%)
		leucine-rich repeat	461..483	CDD:275380	8/21 (38%)
		leucine-rich repeat	484..506	CDD:275380	7/21 (33%)
		Adgb_C_mid-like	<530..>598	CDD:412094	16/68 (24%)
		IQ motif	570..595	CDD:412094	7/25 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45752
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010