DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sur-8 and phlpp1

DIOPT Version :9

Sequence 1:	NP_001262665.1	Gene:	Sur-8 / 42093	FlyBaseID:	FBgn0038504	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	XP_009294739.3	Gene:	phlpp1 / 100331906	ZFINID:	ZDB-GENE-131127-271	Length:	1483	Species:	Danio rerio

Alignment Length:	556	Identity:	135/556 - (24%)
Similarity:	233/556 - (41%)	Gaps:	132/556 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 IQADQDVIKALQRCRDEGIKRLDLSKSSITVIPSTVKECVHLTELYLYSNKIGQLPPEIGCLVSL 208
            :.|||.:   ||..|...::.|:||.:.:...|..:.....|:|:.|..|::..:.|:|..:.||
Zfish   480 LPADQTL---LQLQRFSRLRSLNLSNNQLCSFPQALCSISSLSEVNLSCNRLRSISPDIARISSL 541

  Fly   209 RNLALNENSLTSLPESLQNCSQLKVLDLRHNKLAEIPPVIYRL---------------------R 252
            :.|.|:.|.|.|||..|.:..:|..|.|..|:..::|||:.||                     |
Zfish   542 QTLVLDGNLLCSLPLELGSLHRLVFLGLSFNEFQQVPPVLERLPAVERLCMAGNKLTELNLQSFR 606

  Fly   253 SLTTLY--LRFNRITAV-ADDLRQLVNLTMLSLRENKIRELGSAIGALVNLTTLDVSHNHLEHLP 314
            .||..:  ||.|:|::| .|:...|..:|.|.||:|.::||.:::  ...|..|....|.:..|.
Zfish   607 LLTVRHVDLRLNQISSVLRDEPEFLRGVTQLDLRDNCLQELDASV--FPRLEVLHCQRNRISQLR 669

  Fly   315 EDIGNC-VNLSALDLQHNELLDIPDSIGNLKSLVRLGMRYNRLSSVPATLKNCKSMDEFNVEGNG 378
            .    | ..|.||...:|||.:|..|.. ..:|..:.:..|.:.::|..|.:.:.::..::..|.
Zfish   670 V----CGAALKALHASNNELQEILVSPA-ASNLTYIDISRNCMKALPDWLSDSRKLEVLDISHNQ 729

  Fly   379 ITQLPDGMLASLSGLTTITLSRNQFASYPTGGPAQFTNVYSINLEHNRIDKIPYGIFSRAKGLTK 443
            :|:||..:|.| |.|..|....||..............|  ::|:||:::::|..:|.:...|..
Zfish   730 MTELPPWLLCS-SSLRKILAGHNQLKRLSERVERPLVEV--LDLQHNQLEELPCNLFLKTDSLRC 791

  Fly   444 LNMKENMLTALPLDIGTWVNMVELNLATNALQKLPDDIMNLQNLEILILSNNML--KKIPNTIGN 506
            ||:..|.|.:||               .::|.:....|     |:.|.|:||:|  |.:|...|:
Zfish   792 LNVSANKLESLP---------------ASSLSEESSSI-----LQELYLTNNLLTDKCVPQLTGH 836

  Fly   507 LRKLRILDLEENRIEVLP--HEIGLLHE------------------------------------- 532
            .. ||||.:..|:::..|  |.:| .|:
Zfish   837 TH-LRILHMAYNQLQTFPASHFVG-KHQSFEFDLSGXMLMFCVCVCVCVCVCVCVCVCVCVCVCV 899

  Fly   533 -----LQRLILQTNQITMLPRSIGHLGNLTHLSVSENNLQFLPEEIGSLESLENLYIN-QNPGLE 591
                 :|.:.|..|:             |:.:::.|.    ||.::..|:...||.:| .:..||
Zfish   900 CVCVCVQCVDLSCNE-------------LSDITLPET----LPPKLQELDLTGNLRLNLDHKTLE 947

  Fly   592 KLPFELALCQNLKYLNIDKCPLSTIPPEIQAGGPSL 627
            :|       .|::...||. |.|:......:|||::
Zfish   948 QL-------NNIRCFRIDP-PPSSFSANEASGGPAV 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sur-8	NP_001262665.1	leucine-rich repeat	163..184	CDD:275380	4/20 (20%)
		leucine-rich repeat	185..207	CDD:275380	6/21 (29%)
		LRR_RI	204..401	CDD:238064	62/221 (28%)
		LRR_8	207..264	CDD:290566	25/79 (32%)
		leucine-rich repeat	208..230	CDD:275380	9/21 (43%)
		leucine-rich repeat	231..253	CDD:275380	9/42 (21%)
		LRR_8	252..310	CDD:290566	20/60 (33%)
		leucine-rich repeat	254..276	CDD:275380	9/24 (38%)
		leucine-rich repeat	277..299	CDD:275380	7/21 (33%)
		LRR_8	299..356	CDD:290566	15/57 (26%)
		leucine-rich repeat	300..322	CDD:275380	5/22 (23%)
		leucine-rich repeat	323..345	CDD:275380	8/21 (38%)
		LRR_8	344..403	CDD:290566	14/58 (24%)
		leucine-rich repeat	346..368	CDD:275380	4/21 (19%)
		leucine-rich repeat	369..392	CDD:275380	6/22 (27%)
		LRR_RI	<379..566	CDD:238064	48/232 (21%)
		leucine-rich repeat	417..440	CDD:275380	6/22 (27%)
		leucine-rich repeat	441..486	CDD:275380	9/44 (20%)
		LRR_8	463..520	CDD:290566	16/58 (28%)
		leucine-rich repeat	487..507	CDD:275380	9/21 (43%)
		leucine-rich repeat	510..532	CDD:275380	8/23 (35%)
		LRR_8	532..588	CDD:290566	11/98 (11%)
		leucine-rich repeat	556..578	CDD:275380	5/21 (24%)
		leucine-rich repeat	603..626	CDD:275380	6/22 (27%)
phlpp1	XP_009294739.3	PH-like	343..439	CDD:327399
		LRR_8	446..505	CDD:316378	9/27 (33%)
		leucine-rich repeat	470..494	CDD:275380	6/16 (38%)
		LRR_8	493..551	CDD:316378	15/57 (26%)
		leucine-rich repeat	495..517	CDD:275380	4/21 (19%)
		leucine-rich repeat	518..540	CDD:275380	6/21 (29%)
		leucine-rich repeat	541..563	CDD:275380	9/21 (43%)
		leucine-rich repeat	564..586	CDD:275380	9/21 (43%)
		NEL	569..>860	CDD:330839	84/322 (26%)
		leucine-rich repeat	587..608	CDD:275380	1/20 (5%)
		leucine-rich repeat	610..633	CDD:275380	7/22 (32%)
		leucine-rich repeat	634..674	CDD:275380	12/45 (27%)
		leucine-rich repeat	675..696	CDD:275380	8/21 (38%)
		leucine-rich repeat	697..719	CDD:275380	4/21 (19%)
		leucine-rich repeat	720..742	CDD:275380	6/22 (27%)
		leucine-rich repeat	743..764	CDD:275380	4/20 (20%)
		leucine-rich repeat	766..788	CDD:275380	6/23 (26%)
		leucine-rich repeat	789..812	CDD:275380	8/37 (22%)
		leucine-rich repeat	815..838	CDD:275380	9/22 (41%)
		leucine-rich repeat	839..859	CDD:275380	7/19 (37%)
		PP2Cc	970..1222	CDD:214625	3/6 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910