DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sur-8 and XB964897

DIOPT Version :9

Sequence 1:	NP_001262665.1	Gene:	Sur-8 / 42093	FlyBaseID:	FBgn0038504	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_001123809.1	Gene:	XB964897 / 100170560	XenbaseID:	XB-GENE-964898	Length:	798	Species:	Xenopus tropicalis

Alignment Length:	641	Identity:	145/641 - (22%)
Similarity:	250/641 - (39%)	Gaps:	166/641 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 PPETRPKMVTVKHPESNKPKPTTKKSKPIQADQDVIKALQRCRDEGIKRLDLSKS---------- 170
            |.|...|...|..|..::|...|...||:.....|.||..|..||  |..:.:|:
Frog   180 PKEKHSKKNNVSKPNISQPVTETPLLKPVAETSIVDKAAARDLDE--KEREQAKALFEKVKKIRY 242

  Fly   171 ----SITVI----PSTVKECVHLTELYLYSNK-IGQLPPEIGCLVSLRNLALNENSLTSLPESLQ 226
                ||.:|    ..|:.:.:|...|..|:.. :.::...:.|.|.:.::....|...:||
Frog   243 HVEGSIILIVIYVNQTILKLLHSLFLIGYNGALVSEIQFTVDCEVDIEDVTGYNNFYCNLP---- 303

  Fly   227 NCSQLKVLDLRHNKLAEIPPV-------------IYRLRSLTTLYLRFNR--------------- 263
                             :.|:             :|.|..|.|||...:|
Frog   304 -----------------MAPLFSKMSFFYLCLVGVYGLCCLYTLYWLLHRSLKQYSFEYVRVETG 351

  Fly   264 ---ITAVADDLRQLVNL-----TMLSLR---------ENKIRELGSAIGALVNLTTLDV------ 305
               |..|.:||..|.::     .:.|.|         |||:::|.     |.|..|::.
Frog   352 INDIPDVKNDLAFLFHMIDQYDPLYSKRFAVFLSEASENKLKQLN-----LNNEWTVEKLRLKLQ 411

  Fly   306 --SHNHLE-H------LPEDIGNCVNLSALDLQHNELLDIPDSIGNLKSLVRLGM---------- 351
              :.|.|| |      ||:.:.....|.:|.|:....:.||.:|..|.:|..|.:
Frog   412 TNASNRLELHLLKLPGLPDTVFEITELQSLKLESIPNVMIPAAIAQLNNLQELSLWTCPAKIHSA 476

  Fly   352 -------RYNRLS-------SVPATLKNCKSMDEFNVEG-------------------------- 376
                   ..:.||       .:|..:.:..|::|.|:.|
Frog   477 ALAFLKENVHSLSVKFVGSPHIPQWMCDLGSLEELNLTGLFTPEISKHFPNYSFKKLKSLKHLVI 541

  Fly   377 -NGITQLPDGMLASLSGLTTITLSRNQFASYPTGGPAQFTNVYSINLEHNRIDKIPYGIFSRAKG 440
             :.:|.:|...:...:.|..:::..|:.............|:.::.|.:.::|:||..||| ...
Frog   542 NSNLTSIPQYAVDISAQLQKLSIDNNEIKLVTRNSLKNMANLMTLELVNCKLDQIPNSIFS-LLA 605

  Fly   441 LTKLNMKENMLTALPLDIGTWVNMVELNLAT---NALQKLPDDIMNLQNLEILILSNNMLKKIPN 502
            |.:|::|.|.|.::. :|.::.|:.:|::..   |::.|:||.|..|.|||.|.:|:|.:..:|:
Frog   606 LKELDLKNNNLKSIQ-EIASFQNLQKLSILKLWHNSITKIPDHISKLANLEQLYISHNNIGDLPH 669

  Fly   503 TIGNLRKLRILDLEENRIEVLPHEIGLLHELQRLILQTNQITMLPRSIGHLGNLTHLSVSENNLQ 567
            .:....|||.|:|..|.|..:||.|..|..|:...:..|:|..:|..:.....|..|::..||:.
Frog   670 DLFLCCKLRHLELSNNNIRSIPHIIRNLSNLKYFSVSYNRIETIPDELYFCQKLETLNLRHNNIN 734

  Fly   568 FLPEEIGSLESLENLYINQNPGLEKLPFELALCQNLKY--LNIDKCPLSTIPPEIQ 621
            .|...||:|..|..|.:.:|| :..||.||..||.||.  |:::.....|:|.:|:
Frog   735 TLSPNIGNLAQLSCLDVKENP-IGSLPLELGSCQALKRNGLSVEDRLFETLPFDIR 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sur-8	NP_001262665.1	leucine-rich repeat	163..184	CDD:275380	6/38 (16%)
		leucine-rich repeat	185..207	CDD:275380	3/22 (14%)
		LRR_RI	204..401	CDD:238064	52/307 (17%)
		LRR_8	207..264	CDD:290566	11/87 (13%)
		leucine-rich repeat	208..230	CDD:275380	3/21 (14%)
		leucine-rich repeat	231..253	CDD:275380	3/34 (9%)
		LRR_8	252..310	CDD:290566	20/97 (21%)
		leucine-rich repeat	254..276	CDD:275380	10/39 (26%)
		leucine-rich repeat	277..299	CDD:275380	7/35 (20%)
		LRR_8	299..356	CDD:290566	17/88 (19%)
		leucine-rich repeat	300..322	CDD:275380	7/36 (19%)
		leucine-rich repeat	323..345	CDD:275380	7/21 (33%)
		LRR_8	344..403	CDD:290566	13/109 (12%)
		leucine-rich repeat	346..368	CDD:275380	5/45 (11%)
		leucine-rich repeat	369..392	CDD:275380	5/49 (10%)
		LRR_RI	<379..566	CDD:238064	51/189 (27%)
		leucine-rich repeat	417..440	CDD:275380	7/22 (32%)
		leucine-rich repeat	441..486	CDD:275380	14/47 (30%)
		LRR_8	463..520	CDD:290566	21/59 (36%)
		leucine-rich repeat	487..507	CDD:275380	6/19 (32%)
		leucine-rich repeat	510..532	CDD:275380	10/21 (48%)
		LRR_8	532..588	CDD:290566	14/55 (25%)
		leucine-rich repeat	556..578	CDD:275380	8/21 (38%)
		leucine-rich repeat	603..626	CDD:275380	6/21 (29%)
XB964897	NP_001123809.1	leucine-rich repeat	606..630	CDD:275380	7/24 (29%)
		leucine-rich repeat	631..653	CDD:275380	7/21 (33%)
		leucine-rich repeat	654..676	CDD:275380	6/21 (29%)
		LRR_8	676..733	CDD:290566	18/56 (32%)
		leucine-rich repeat	677..699	CDD:275380	10/21 (48%)
		leucine-rich repeat	700..722	CDD:275380	4/21 (19%)
		leucine-rich repeat	723..745	CDD:275380	8/21 (38%)
		leucine-rich repeat	746..766	CDD:275380	8/20 (40%)
		Pannexin_like	1..330	CDD:289311	33/172 (19%)
		leucine-rich repeat	392..437	CDD:275380	10/49 (20%)
		leucine-rich repeat	488..504	CDD:275380	3/15 (20%)
		LRR_RI	534..767	CDD:238064	64/235 (27%)
		leucine-rich repeat	536..558	CDD:275380	2/21 (10%)
		LRR_8	558..616	CDD:290566	14/58 (24%)
		leucine-rich repeat	559..582	CDD:275380	2/22 (9%)
		leucine-rich repeat	583..605	CDD:275380	7/22 (32%)
		LRR_8	606..664	CDD:290566	20/58 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910