DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sds22 and DNAL1

DIOPT Version :9

Sequence 1:	NP_650619.1	Gene:	sds22 / 42091	FlyBaseID:	FBgn0028992	Length:	326	Species:	Drosophila melanogaster
Sequence 2:	NP_113615.2	Gene:	DNAL1 / 83544	HGNCID:	23247	Length:	190	Species:	Homo sapiens

Alignment Length:	165	Identity:	50/165 - (30%)
Similarity:	84/165 - (50%)	Gaps:	28/165 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 LKKIE-NIEMLVNLRQLFLGKNKIAKIENLDTLVNLEILSLQANRIVKIENLEKLAN-LRELYVS 223
            ::|:: ::.||.|..:|.|..|.|.||.||:.|.||.||||..|.|..:..||.:.: |.||::|
Human    37 IEKMDASLSMLANCEKLSLSTNCIEKIANLNGLKNLRILSLGRNNIKNLNGLEAVGDTLEELWIS 101

  Fly   224 ENGVETIENLSENTKLETLDLAKNRLKGIANLEKLELLEELWLNHNGVDDWKDIELLKVNKALQT 288
            .|.:|                   :||||..::||::   |::::|.|.||.:...|.....|:.
Human   102 YNFIE-------------------KLKGIHIMKKLKI---LYMSNNLVKDWAEFVKLAELPCLED 144

  Fly   289 IYLEYNPL----AKDVRYRSKLRDILPQLQKIDAT 319
            :....|||    :.:..:..:....:|:|:|:|.|
Human   145 LVFVGNPLEEKHSAENNWIEEATKRVPKLKKLDGT 179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sds22	NP_650619.1	leucine-rich repeat	43..62	CDD:275380
		LRR_8	61..117	CDD:290566
		leucine-rich repeat	63..84	CDD:275380
		LRR_4	83..125	CDD:289563
		leucine-rich repeat	85..106	CDD:275380
		LRR_8	105..183	CDD:290566	7/22 (32%)
		leucine-rich repeat	107..128	CDD:275380
		LRR_4	128..168	CDD:289563	1/7 (14%)
		leucine-rich repeat	129..150	CDD:275380
		LRR_4	149..189	CDD:289563	10/28 (36%)
		leucine-rich repeat	151..172	CDD:275380	3/11 (27%)
		leucine-rich repeat	173..194	CDD:275380	9/20 (45%)
		LRR_8	194..249	CDD:290566	16/55 (29%)
		LRR_4	194..235	CDD:289563	16/41 (39%)
		leucine-rich repeat	195..216	CDD:275380	9/20 (45%)
		leucine-rich repeat	217..238	CDD:275380	6/20 (30%)
DNAL1	NP_113615.2	LRR_4	49..89	CDD:289563	18/39 (46%)
		LRR 1	49..70		9/20 (45%)
		leucine-rich repeat	50..71	CDD:275378	9/20 (45%)
		LRR_8	70..127	CDD:290566	24/78 (31%)
		LRR 2	71..92		10/20 (50%)
		leucine-rich repeat	72..90	CDD:275378	8/17 (47%)
		LRR 3	94..115		10/39 (26%)
		LRR_4	95..133	CDD:289563	17/59 (29%)
		leucine-rich repeat	95..116	CDD:275382	10/39 (26%)
		LRR 4	116..137		7/23 (30%)
		leucine-rich repeat	117..140	CDD:275382	7/25 (28%)
		leucine-rich repeat	142..172	CDD:275382	4/29 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900