DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sds22 and Lrrc9

DIOPT Version :9

Sequence 1:	NP_650619.1	Gene:	sds22 / 42091	FlyBaseID:	FBgn0028992	Length:	326	Species:	Drosophila melanogaster
Sequence 2:	XP_006516438.1	Gene:	Lrrc9 / 78257	MGIID:	1925507	Length:	1457	Species:	Mus musculus

Alignment Length:	436	Identity:	95/436 - (21%)
Similarity:	154/436 - (35%)	Gaps:	165/436 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 NHRRIEKLENFEPLTRIERLFLRWNLIKKIENLSSLKTLIELELYDNQITKIE--NLDDLPHLEV 109
            ::..:.|:|..|....:|.|.|..|.|.|||.::.|..|..|.:.:|.:|.:|  ..|:|.||..
Mouse   908 SNNNLSKMEGLESCVNLEELTLDGNCISKIEGITRLTKLSRLSMNNNLLTGLEKHTFDNLLHLHS 972

  Fly   110 LDISFNRLTKIENLDKLVKLEKVYFVSNRIT---QIENLDMLTNLTMLELGDN------------ 159
            |.:..||:|.:..|.|...|.::|..:|.|.   :|.||..|.||.:|::..|
Mouse   973 LSLENNRITSLSALQKTFTLIELYISNNYIAVNQEIYNLKGLCNLVILDMYGNIIIWNQENYRFF 1037

  Fly   160 ------KLKKIENIEM------------------------------------------------- 169
                  :||.::.:.:
Mouse  1038 VIFHLPELKALDGVSIETSETETAKDLFGGRLTSDMIAERQGHSNFIQMQELNWTSSAIRTVDLI 1102

  Fly   170 --------------------------LVNLRQLFLGKNKIAKI---------------------- 186
                                      |.|::.|.|..|.|..|
Mouse  1103 PVDHFRNVSNVNLQNNNLTSFSGLIYLPNVKVLCLNYNHIESIMPRLKPQTHLSSRQLLYQKVPS 1167

  Fly   187 ------------------EN-------------------------LDTLVNLEILSLQANRIVKI 208
                              ||                         |:.|.||:.|.||.|.|.::
Mouse  1168 SGYGQQGTSKLNRDSVGSENLPPIMQSLEVLHLGYNGICNLVQLQLNRLRNLKFLFLQGNEISQV 1232

  Fly   209 ENLEKLANLRELYVSENGVETIEN--LSENTKLETLDLAKNRLKGIANLEKLELLEELWLNHNGV 271
            |.|:.|..|:||.|..|.:....:  .|:.:.|..|.|.:|||:.::.|:.|..||:|:|.:|.:
Mouse  1233 EGLDNLIVLQELVVDHNRIRAFNDTAFSKPSSLLMLHLEENRLRELSKLQSLVKLEKLFLGYNKI 1297

  Fly   272 DDWKDIELLKVNKALQTIYLEYNPLAKDVRYRSKLRDILPQLQKID 317
            .|..::|.|.|..:|:.:.:..||:.:.:.:|..|...||.||.:|
Mouse  1298 QDITELEKLDVIPSLRELTVYGNPICRKMVHRHVLIFRLPNLQMLD 1343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sds22	NP_650619.1	leucine-rich repeat	43..62	CDD:275380	3/14 (21%)
		LRR_8	61..117	CDD:290566	20/57 (35%)
		leucine-rich repeat	63..84	CDD:275380	9/20 (45%)
		LRR_4	83..125	CDD:289563	14/43 (33%)
		leucine-rich repeat	85..106	CDD:275380	7/22 (32%)
		LRR_8	105..183	CDD:290566	27/173 (16%)
		leucine-rich repeat	107..128	CDD:275380	7/20 (35%)
		LRR_4	128..168	CDD:289563	14/60 (23%)
		leucine-rich repeat	129..150	CDD:275380	8/23 (35%)
		LRR_4	149..189	CDD:289563	15/197 (8%)
		leucine-rich repeat	151..172	CDD:275380	6/113 (5%)
		leucine-rich repeat	173..194	CDD:275380	9/85 (11%)
		LRR_8	194..249	CDD:290566	20/56 (36%)
		LRR_4	194..235	CDD:289563	15/42 (36%)
		leucine-rich repeat	195..216	CDD:275380	9/20 (45%)
		leucine-rich repeat	217..238	CDD:275380	6/22 (27%)
Lrrc9	XP_006516438.1	internalin_A	<32..>264	CDD:380193
		leucine-rich repeat	47..77	CDD:275380
		leucine-rich repeat	78..99	CDD:275380
		leucine-rich repeat	100..121	CDD:275380
		leucine-rich repeat	122..143	CDD:275380
		leucine-rich repeat	144..166	CDD:275380
		leucine-rich repeat	167..191	CDD:275380
		leucine-rich repeat	192..223	CDD:275380
		internalin_A	685..>959	CDD:380193	16/50 (32%)
		leucine-rich repeat	689..708	CDD:275380
		leucine-rich repeat	709..730	CDD:275380
		leucine-rich repeat	731..752	CDD:275380
		leucine-rich repeat	753..779	CDD:275380
		leucine-rich repeat	780..806	CDD:275380
		leucine-rich repeat	807..865	CDD:275380
		leucine-rich repeat	866..901	CDD:275380
		internalin_A	879..>1262	CDD:380193	68/353 (19%)
		leucine-rich repeat	902..923	CDD:275380	3/14 (21%)
		leucine-rich repeat	924..945	CDD:275380	9/20 (45%)
		leucine-rich repeat	946..969	CDD:275380	7/22 (32%)
		leucine-rich repeat	992..1016	CDD:275380	8/23 (35%)
		leucine-rich repeat	1017..1044	CDD:275380	3/26 (12%)
		leucine-rich repeat	1132..1157	CDD:275380	5/24 (21%)
		leucine-rich repeat	1158..1194	CDD:275380	2/35 (6%)
		leucine-rich repeat	1195..1218	CDD:275380	2/22 (9%)
		leucine-rich repeat	1219..1240	CDD:275380	9/20 (45%)
		LRR_9	<1227..1366	CDD:373143	38/117 (32%)
		leucine-rich repeat	1241..1264	CDD:275380	6/22 (27%)
		leucine-rich repeat	1265..1286	CDD:275380	8/20 (40%)
		leucine-rich repeat	1287..1311	CDD:275380	9/23 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810