DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sds22 and lrrc9

DIOPT Version :9

Sequence 1:	NP_650619.1	Gene:	sds22 / 42091	FlyBaseID:	FBgn0028992	Length:	326	Species:	Drosophila melanogaster
Sequence 2:	XP_017951824.1	Gene:	lrrc9 / 780204	XenbaseID:	XB-GENE-1011352	Length:	1514	Species:	Xenopus tropicalis

Alignment Length:	400	Identity:	102/400 - (25%)
Similarity:	152/400 - (38%)	Gaps:	124/400 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 AEDVAS----IEDIITIDP----------------------DCYE----LDLNHRRIEKLENFEP 59
            ||||:.    .||.|.::|                      :.|.    |:|:...:.||::...
Frog   656 AEDVSHDLKLDEDAIALEPFLKPKPKIISLDEKTVLSVARANIYSQITVLNLHGNSLSKLKDISR 720

  Fly    60 LTRIERLFLRWNLIKKIENLSSLKTLIELELYDNQITKIENLDDLPHLEVLDISFNRLT------ 118
            |..:.:|.:.:|....:|::|.|..|..|:...||:..:|....|..|:.||:|:|:||
Frog   721 LNGLRKLIISFNEFSSLEDVSYLTNLEYLDASHNQVITLEGFKGLGKLKYLDLSWNKLTNSREDL 785

  Fly   119 --------KIENLD---------------------KLVKLEKVYFV------------SNRITQI 142
                    ::.:||                     .|..|..|...            .:||||.
Frog   786 HILRKHAIQLSSLDIRYNFWQKPASVLKDTIAILPSLTHLNGVTITEDEISEALQISSGSRITQA 850

  Fly   143 ENL--------------------------------------DMLTNLTMLELGDNKLKKIENIEM 169
            ..|                                      ...|.:|.|.|....|.:|.|:|.
Frog   851 SLLINARTDTVKPRCLNLLPSAQILAQFSKNCLDPNAELSNSWYTKITSLTLDSQNLVRITNLEK 915

  Fly   170 LVNLRQLFLGKNKIAKIENLDTLVNLEILSLQANRIVKIENLEKLANLRELYVSEN---GVE--T 229
            |||||......|.:.|||.|:..||||.|:|..|.|.|:|.|.||..||.|.::.|   |.:  .
Frog   916 LVNLRWASFSSNHLTKIEGLEHCVNLEELNLDDNSISKLEGLSKLTKLRRLSINNNLLAGFDRHV 980

  Fly   230 IENLSENTKLETLDLAKNRLKGIANLEKLELLEELWLNHNGVDDWKDIELLKVNKALQTIYLEYN 294
            ||:||.   |..|....|.:..:|.|::...|.||:|::|.:...::|..||....|..:.:..|
Frog   981 IESLSH---LHFLSAENNNISSLAGLQRGYKLIELYLSNNCISSNQEIYSLKGLNNLVILDMWGN 1042

  Fly   295 P-LAKDVRYR 303
            | |.|...||
Frog  1043 PILLKHENYR 1052

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sds22	NP_650619.1	leucine-rich repeat	43..62	CDD:275380	5/22 (23%)
		LRR_8	61..117	CDD:290566	16/55 (29%)
		leucine-rich repeat	63..84	CDD:275380	5/20 (25%)
		LRR_4	83..125	CDD:289563	15/76 (20%)
		leucine-rich repeat	85..106	CDD:275380	6/20 (30%)
		LRR_8	105..183	CDD:290566	31/162 (19%)
		leucine-rich repeat	107..128	CDD:275380	10/55 (18%)
		LRR_4	128..168	CDD:289563	14/89 (16%)
		leucine-rich repeat	129..150	CDD:275380	7/70 (10%)
		LRR_4	149..189	CDD:289563	17/39 (44%)
		leucine-rich repeat	151..172	CDD:275380	8/20 (40%)
		leucine-rich repeat	173..194	CDD:275380	7/20 (35%)
		LRR_8	194..249	CDD:290566	24/59 (41%)
		LRR_4	194..235	CDD:289563	20/45 (44%)
		leucine-rich repeat	195..216	CDD:275380	11/20 (55%)
		leucine-rich repeat	217..238	CDD:275380	9/25 (36%)
lrrc9	XP_017951824.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910