DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sds22 and Lrrc46

DIOPT Version :9

Sequence 1:	NP_650619.1	Gene:	sds22 / 42091	FlyBaseID:	FBgn0028992	Length:	326	Species:	Drosophila melanogaster
Sequence 2:	NP_081302.2	Gene:	Lrrc46 / 69297	MGIID:	1916547	Length:	323	Species:	Mus musculus

Alignment Length:	151	Identity:	50/151 - (33%)
Similarity:	80/151 - (52%)	Gaps:	5/151 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 EMLVNLRQL-FLGKNKIAKIENLDTLVNLEILSLQANRIVKIENLEKLANLRELYVSENGVETIE 231
            |.|:..|.| |.|...::: :...||..||.:.|....|..|.|||||.|:..||:..|.::.||
Mouse    23 EALITKRNLTFPGDEDLSE-KMFHTLGELETVRLDGEGITCIGNLEKLRNIHSLYLQSNKIQRIE 86

  Fly   232 NLSENTKLETLDLAKNRLKGIANLEKLELLEELWLNHNGVDDWKDIELLKVNKALQTIYLEYNPL 296
            ||:..|.|..|.||:|:::.:.||..|:.|:.|.|:.|.::   .::|.::.::|..:.|..||.
Mouse    87 NLACITSLRFLSLARNQIRHVENLLDLQYLQFLDLSENLIE---TLKLDELPESLLILNLCGNPC 148

  Fly   297 AKDVRYRSKLRDILPQLQKID 317
            .....||..:...||.|..:|
Mouse   149 TNQEGYRKMVIGALPLLLDLD 169

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sds22	NP_650619.1	leucine-rich repeat	43..62	CDD:275380
		LRR_8	61..117	CDD:290566
		leucine-rich repeat	63..84	CDD:275380
		LRR_4	83..125	CDD:289563
		leucine-rich repeat	85..106	CDD:275380
		LRR_8	105..183	CDD:290566	6/15 (40%)
		leucine-rich repeat	107..128	CDD:275380
		LRR_4	128..168	CDD:289563	50/151 (33%)
		leucine-rich repeat	129..150	CDD:275380
		LRR_4	149..189	CDD:289563	6/21 (29%)
		leucine-rich repeat	151..172	CDD:275380	2/3 (67%)
		leucine-rich repeat	173..194	CDD:275380	6/21 (29%)
		LRR_8	194..249	CDD:290566	24/54 (44%)
		LRR_4	194..235	CDD:289563	18/40 (45%)
		leucine-rich repeat	195..216	CDD:275380	10/20 (50%)
		leucine-rich repeat	217..238	CDD:275380	7/20 (35%)
Lrrc46	NP_081302.2	LRR 1	49..70		9/20 (45%)
		LRR_4	50..89	CDD:289563	17/38 (45%)
		leucine-rich repeat	50..71	CDD:275378	10/20 (50%)
		LRR_8	70..126	CDD:290566	21/55 (38%)
		LRR_4	71..110	CDD:289563	14/38 (37%)
		LRR 2	71..92		8/20 (40%)
		leucine-rich repeat	72..93	CDD:275378	7/20 (35%)
		LRR_4	92..130	CDD:289563	13/40 (33%)
		LRR 3	93..114		7/20 (35%)
		leucine-rich repeat	94..115	CDD:275378	8/20 (40%)
		LRR 4	115..135		5/22 (23%)
		leucine-rich repeat	116..137	CDD:275378	5/23 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..323
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810