DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sds22 and LRRC61

DIOPT Version :9

Sequence 1:	NP_650619.1	Gene:	sds22 / 42091	FlyBaseID:	FBgn0028992	Length:	326	Species:	Drosophila melanogaster
Sequence 2:	NP_001136400.1	Gene:	LRRC61 / 65999	HGNCID:	21704	Length:	259	Species:	Homo sapiens

Alignment Length:	173	Identity:	48/173 - (27%)
Similarity:	73/173 - (42%)	Gaps:	25/173 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 LDMLTNLTMLELGDNKLKKIENIEMLVNLRQLFLGKNKIAKIENLDTLVNLEILSLQANRIVKIE 209
            |.:...|.....|:..|:.|    :|:.||.|.|     |.:..|...:.||.|.|..|.:..:.
Human    14 LQITPQLLKSRTGEFSLESI----LLLKLRGLGL-----ADLGCLGECLGLEWLDLSGNALTHLG 69

  Fly   210 NLEKLANLRELYVSENGVETIENLSENTKLETLDLAKNRLKGIANLEKLELLEELWLNHNGVDDW 274
            .|..|..|..|.||.|.:..:|.|:....|::|:.|.|.|.....|:.|..|..|
Human    70 PLASLRQLAVLNVSNNRLTGLEPLATCENLQSLNAAGNLLATPGQLQCLAGLPCL---------- 124

  Fly   275 KDIELLKVNKALQTIYLEYNPLAKDVRYRSKLRDILPQLQKID 317
               |.|::...|..:   .|||..:..|.:.:|::||.|:.||
Human   125 ---EYLRLRDPLARL---SNPLCANPSYWAAVRELLPGLKVID 161

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sds22	NP_650619.1	leucine-rich repeat	43..62	CDD:275380
		LRR_8	61..117	CDD:290566
		leucine-rich repeat	63..84	CDD:275380
		LRR_4	83..125	CDD:289563
		leucine-rich repeat	85..106	CDD:275380
		LRR_8	105..183	CDD:290566	10/37 (27%)
		leucine-rich repeat	107..128	CDD:275380
		LRR_4	128..168	CDD:289563	5/22 (23%)
		leucine-rich repeat	129..150	CDD:275380	1/4 (25%)
		LRR_4	149..189	CDD:289563	10/39 (26%)
		leucine-rich repeat	151..172	CDD:275380	5/20 (25%)
		leucine-rich repeat	173..194	CDD:275380	6/20 (30%)
		LRR_8	194..249	CDD:290566	18/54 (33%)
		LRR_4	194..235	CDD:289563	14/40 (35%)
		leucine-rich repeat	195..216	CDD:275380	7/20 (35%)
		leucine-rich repeat	217..238	CDD:275380	7/20 (35%)
LRRC61	NP_001136400.1	LRR 1	32..53		8/29 (28%)
		LRR 2	54..75		6/20 (30%)
		leucine-rich repeat	55..76	CDD:275380	7/20 (35%)
		LRR_9	<58..165	CDD:317038	34/120 (28%)
		LRR 3	76..97		7/20 (35%)
		leucine-rich repeat	77..98	CDD:275380	7/20 (35%)
		LRR 4	98..119		6/20 (30%)
		leucine-rich repeat	99..123	CDD:275380	8/23 (35%)
		leucine-rich repeat	124..149	CDD:275380	8/40 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900