DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sds22 and Lrrc56

DIOPT Version :9

Sequence 1:	NP_650619.1	Gene:	sds22 / 42091	FlyBaseID:	FBgn0028992	Length:	326	Species:	Drosophila melanogaster
Sequence 2:	NP_001020073.1	Gene:	Lrrc56 / 365389	RGDID:	1311654	Length:	548	Species:	Rattus norvegicus

Alignment Length:	198	Identity:	56/198 - (28%)
Similarity:	93/198 - (46%)	Gaps:	34/198 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 ITQIENLDMLTNLTMLELGDNKLKKIENIEM-LVNLRQLFLGKNKIAKIENLDT-LVNLEILSLQ 201
            :.|:::|.::..|.|..  |.:...:.|..| |.||.||.|..:.:..:.:|.| |..|::|.|.
  Rat    62 LAQVDDLQLVRVLEMCV--DTRKNSLGNFGMHLPNLIQLKLNHSCLGSLRDLGTSLGQLQVLWLA 124

  Fly   202 ANRIVKIENLEKLANLRELYVSENGVETIENLSENTKLETLDLAKNRLKGIANLEKLEL---LEE 263
            ...:..::.:.....|:|||||.|.:..:..|....:||.|||..|.::.:..:..|:|   |..
  Rat   125 RCGLTDLDGIGSFLALKELYVSYNNISDLSPLCLLEQLEVLDLEGNNVEDLGQMRYLQLCPRLTT 189

  Fly   264 LWLNHNGVDDWKDIELLK-----VNKALQTIYLEYNPLAKDVRYRSKLRDILPQLQKIDATLCKV 323
            |.|..|       :..||     .|||.|    :||       ||::::.::|||..:|    :|
  Rat   190 LTLEGN-------LVCLKPDPGPSNKAPQ----DYN-------YRAEVKKLIPQLHILD----EV 232

  Fly   324 PGT 326
            |.|
  Rat   233 PTT 235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sds22	NP_650619.1	leucine-rich repeat	43..62	CDD:275380
		LRR_8	61..117	CDD:290566
		leucine-rich repeat	63..84	CDD:275380
		LRR_4	83..125	CDD:289563
		leucine-rich repeat	85..106	CDD:275380
		LRR_8	105..183	CDD:290566	13/44 (30%)
		leucine-rich repeat	107..128	CDD:275380
		LRR_4	128..168	CDD:289563	6/28 (21%)
		leucine-rich repeat	129..150	CDD:275380	2/10 (20%)
		LRR_4	149..189	CDD:289563	11/40 (28%)
		leucine-rich repeat	151..172	CDD:275380	6/21 (29%)
		leucine-rich repeat	173..194	CDD:275380	7/21 (33%)
		LRR_8	194..249	CDD:290566	17/54 (31%)
		LRR_4	194..235	CDD:289563	11/40 (28%)
		leucine-rich repeat	195..216	CDD:275380	3/20 (15%)
		leucine-rich repeat	217..238	CDD:275380	8/20 (40%)
Lrrc56	NP_001020073.1	PPP1R42	91..233	CDD:411060	46/163 (28%)
		LRR 1	94..115		7/20 (35%)
		leucine-rich repeat	95..117	CDD:275380	7/21 (33%)
		LRR 2	117..138		3/20 (15%)
		leucine-rich repeat	118..139	CDD:275380	3/20 (15%)
		LRR 3	139..160		8/20 (40%)
		leucine-rich repeat	140..161	CDD:275380	8/20 (40%)
		LRR 4	161..182		6/20 (30%)
		leucine-rich repeat	162..186	CDD:275380	8/23 (35%)
		LRR 5	186..206		6/26 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	405..433
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810