DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sds22 and Lrrc9

DIOPT Version :9

Sequence 1:	NP_650619.1	Gene:	sds22 / 42091	FlyBaseID:	FBgn0028992	Length:	326	Species:	Drosophila melanogaster
Sequence 2:	XP_038967924.1	Gene:	Lrrc9 / 299129	RGDID:	1565716	Length:	1188	Species:	Rattus norvegicus

Alignment Length:	302	Identity:	86/302 - (28%)
Similarity:	142/302 - (47%)	Gaps:	54/302 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 SIEDIITIDPDCYE------LDLNHRRIEKLENFEPLTRIERLFLRWNLIKKI-ENLSSL----K 83
            |..:...:| |.|.      ||.:|..:..||.|..|.:::.|.|.||.:||. |.::.|    .
  Rat   715 SFNEFTCLD-DVYHLYNLEYLDASHNHVITLEGFRGLMKLKHLDLSWNQLKKTGEEINVLCKHTT 778

  Fly    84 TLIELELYDN--------QITKIENLDDLPHLEVLDIS---------FNRLTKIENL-------- 123
            :|:.|::..|        :::.|..|..|.||:.|.||         |...|||..|
  Rat   779 SLLTLDIQHNPWQKPATLRLSVIGRLKTLTHLDGLLISEEETRAALKFISGTKITQLTLLQHSSS 843

  Fly   124 -DKLVKLEKVYFVSNRITQIENL--------DMLTNLTMLELGDNKLKKIENIEMLVNLRQLFLG 179
             ::..::..::..:..:|||..|        :....:|.|.|....|.:|.|:|.|.||:.....
  Rat   844 KEERPRMLSIWPSAKILTQISKLGPHFHLTGNWYLKITALNLDGQHLFEITNLEKLENLKWASFS 908

  Fly   180 KNKIAKIENLDTLVNLEILSLQANRIVKIENLEKLANLRELYVSEN---GVE--TIENLSENTKL 239
            .|.::|:|.|::.||||.|:|..|.|.|||.:.:|..|..|.::.|   |:|  |.:|:   ..|
  Rat   909 NNNLSKMEGLESCVNLEELTLDGNCISKIEGITRLTKLSRLSMNNNLLTGLEKHTFDNM---LHL 970

  Fly   240 ETLDLAKNRLKGIANLEKLELLEELWLNHNGVDDWKDIELLK 281
            .:|.|..||:..::.|:|...|.||::::|.:...::|..||
  Rat   971 HSLSLENNRITSLSALQKTFTLIELYISNNYIAVNQEIYNLK 1012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sds22	NP_650619.1	leucine-rich repeat	43..62	CDD:275380	7/24 (29%)
		LRR_8	61..117	CDD:290566	20/77 (26%)
		leucine-rich repeat	63..84	CDD:275380	8/25 (32%)
		LRR_4	83..125	CDD:289563	16/67 (24%)
		leucine-rich repeat	85..106	CDD:275380	6/28 (21%)
		LRR_8	105..183	CDD:290566	25/103 (24%)
		leucine-rich repeat	107..128	CDD:275380	9/38 (24%)
		LRR_4	128..168	CDD:289563	10/47 (21%)
		leucine-rich repeat	129..150	CDD:275380	4/28 (14%)
		LRR_4	149..189	CDD:289563	13/39 (33%)
		leucine-rich repeat	151..172	CDD:275380	8/20 (40%)
		leucine-rich repeat	173..194	CDD:275380	5/20 (25%)
		LRR_8	194..249	CDD:290566	22/59 (37%)
		LRR_4	194..235	CDD:289563	18/45 (40%)
		leucine-rich repeat	195..216	CDD:275380	10/20 (50%)
		leucine-rich repeat	217..238	CDD:275380	7/25 (28%)
Lrrc9	XP_038967924.1	leucine-rich repeat	47..77	CDD:275380
		leucine-rich repeat	78..99	CDD:275380
		PPP1R42	85..236	CDD:411060
		leucine-rich repeat	100..121	CDD:275380
		leucine-rich repeat	122..143	CDD:275380
		leucine-rich repeat	144..166	CDD:275380
		leucine-rich repeat	167..191	CDD:275380
		leucine-rich repeat	192..223	CDD:275380
		internalin_A	685..>1014	CDD:380193	86/302 (28%)
		leucine-rich repeat	689..708	CDD:275380
		leucine-rich repeat	709..730	CDD:275380	4/15 (27%)
		leucine-rich repeat	731..752	CDD:275380	7/20 (35%)
		leucine-rich repeat	753..779	CDD:275380	8/25 (32%)
		leucine-rich repeat	780..806	CDD:275380	5/25 (20%)
		leucine-rich repeat	807..865	CDD:275380	14/57 (25%)
		leucine-rich repeat	866..901	CDD:275380	9/34 (26%)
		PPP1R42	879..1057	CDD:411060	47/137 (34%)
		leucine-rich repeat	902..923	CDD:275380	5/20 (25%)
		leucine-rich repeat	924..945	CDD:275380	10/20 (50%)
		leucine-rich repeat	946..969	CDD:275380	7/25 (28%)
		leucine-rich repeat	992..1016	CDD:275380	7/21 (33%)
		leucine-rich repeat	1017..1044	CDD:275380
		leucine-rich repeat	1045..1112	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910