DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sds22 and Lrrc43

DIOPT Version :9

Sequence 1:	NP_650619.1	Gene:	sds22 / 42091	FlyBaseID:	FBgn0028992	Length:	326	Species:	Drosophila melanogaster
Sequence 2:	NP_001163867.1	Gene:	Lrrc43 / 288751	RGDID:	1561461	Length:	681	Species:	Rattus norvegicus

Alignment Length:	366	Identity:	81/366 - (22%)
Similarity:	134/366 - (36%)	Gaps:	124/366 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 RIERLFLRWNLIKKIENLSSLKTLIELELYDNQITKIENL--DDLPHLEVLDISFNRLTKIENLD 124
            ::|.|.|..|.||.|:..:...||..||||.|.|..:|.|  ...|:|:.|.:..|:|
  Rat   146 KLEELVLSANKIKDIDANNLPPTLKVLELYGNLIASMECLCSPPPPNLQHLGLGHNKL------- 203

  Fly   125 KLVKLEKVYFVSNRITQIENLDM----LTNLTMLELGDNKLKKIENIEMLVNLRQLFLGKNKIAK 185
             |..||.:|..||....:.:||:    ||:|..:.||.:.||         .||.|.|..|.:|.
  Rat   204 -LGPLESLYVTSNNWPLLVSLDLGFNDLTDLQSMILGLSTLK---------CLRLLVLQGNPLAL 258

  Fly   186 IE-----NLDTLVNL-----------------------EILSLQANRIVKIENLEKLANLREL-- 220
            :.     .:|:|..|                       ::|:.:|..:|.|.|:..:.:...|
  Rat   259 VPYYRGFTVDSLARLCVLDDITVSPSEKHQFRGLNSHGDLLAREAQFVVTIGNVRGVLDSSILDP 323

  Fly   221 -------------YVSENGVET---------IENLSENTKLETLDLAKNRLKGIANLEKLELLEE 263
                         ||:.:.||.         :|.|..::.|:.:|...:   |:...|:.|..||
  Rat   324 EPGPDGPFISYSYYVTYDFVEDEEKEGITSGMEELHPDSVLDEIDKPSS---GMDEEEEEEEEEE 385

  Fly   264 -----------LWLNHNGV--------------------------------DDWKDIELLKVNKA 285
                       ...:|..|                                :|..:..:.:|:::
  Rat   386 EDRQEVLSVFQSQAHHRPVRQGGRHRFRPESPEVMSRELSEYIVKEMNQMAEDSGESGITEVDES 450

  Fly   286 LQTIYLEYNPLAKDVRYRSKLRDILPQLQKIDATLCKVPGT 326
            ..:|.:...||.:.:....:|..:.|:|   |..||..|||
  Rat   451 ETSISIHSAPLPQSIDSSEELAKLRPRL---DVRLCPSPGT 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sds22	NP_650619.1	leucine-rich repeat	43..62	CDD:275380	81/366 (22%)
		LRR_8	61..117	CDD:290566	21/56 (38%)
		leucine-rich repeat	63..84	CDD:275380	7/20 (35%)
		LRR_4	83..125	CDD:289563	15/43 (35%)
		leucine-rich repeat	85..106	CDD:275380	9/22 (41%)
		LRR_8	105..183	CDD:290566	25/81 (31%)
		leucine-rich repeat	107..128	CDD:275380	5/20 (25%)
		LRR_4	128..168	CDD:289563	14/43 (33%)
		leucine-rich repeat	129..150	CDD:275380	8/24 (33%)
		LRR_4	149..189	CDD:289563	12/44 (27%)
		leucine-rich repeat	151..172	CDD:275380	5/20 (25%)
		leucine-rich repeat	173..194	CDD:275380	8/25 (32%)
		LRR_8	194..249	CDD:290566	15/101 (15%)
		LRR_4	194..235	CDD:289563	13/87 (15%)
		leucine-rich repeat	195..216	CDD:275380	6/43 (14%)
		leucine-rich repeat	217..238	CDD:275380	7/44 (16%)
Lrrc43	NP_001163867.1	LRR_RI	<146..254	CDD:238064	41/124 (33%)
		LRR_8	146..203	CDD:290566	21/56 (38%)
		LRR_4	146..187	CDD:289563	17/40 (43%)
		leucine-rich repeat	147..168	CDD:275378	7/20 (35%)
		leucine-rich repeat	169..192	CDD:275378	9/22 (41%)
		LRR_8	191..256	CDD:290566	25/81 (31%)
		leucine-rich repeat	193..219	CDD:275378	10/33 (30%)
		leucine-rich repeat	220..245	CDD:275378	9/33 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45973
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000