DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sds22 and Cntrl

DIOPT Version :9

Sequence 1:	NP_650619.1	Gene:	sds22 / 42091	FlyBaseID:	FBgn0028992	Length:	326	Species:	Drosophila melanogaster
Sequence 2:	NP_001366203.1	Gene:	Cntrl / 26920	MGIID:	1889576	Length:	2334	Species:	Mus musculus

Alignment Length:	268	Identity:	84/268 - (31%)
Similarity:	135/268 - (50%)	Gaps:	53/268 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 LIKKI---ENLSSLKTLIELELYDN---QITKIENLDDLPHLEVLDISFNRLTKIENLDKLVKLE 130
            ||||:   :||:.:|:| .|.|..:   :...||||:....||||::|:|.:.|||.:|||::|.
Mouse    87 LIKKLTKQDNLALVKSL-NLSLSKDGGKKFRYIENLEKCVKLEVLNLSYNLIVKIEKVDKLLRLR 150

  Fly   131 KVYFVSNRITQIENLDMLTNLTMLELGDNKLKKIENI-----EMLVNLRQLFLGKNKIAKIEN-- 188
            ::....|:|::||.|:.:.||..|.|..|   :||:|     :.|.:||.|.|..|||:.:::
Mouse   151 ELNLSYNKISKIEGLENMCNLQKLNLAGN---EIEHIPVWFAKKLKSLRVLNLKGNKISSLQDVS 212

  Fly   189 -LDTLVNLEILSLQANRIVK--------IENLEKLANL---------RELYVSENGVETIENLSE 235
             |..|.:|..|.|..|.:|.        |.:|..|.:|         |:.......:|.||.|.:
Mouse   213 KLKPLQDLTSLVLIDNPVVALPHYLQFIIFHLRSLESLEGQPVTTQDRQEAFERFSLEEIERLEK 277

  Fly   236 NTKLETLDL--AKNR----LKGIANLEKL--ELLEELWLNHNGVDDWK-DI----ELLK-----V 282
            :.:.:|::.  .||:    |:.|.|.:||  .|.||..|.....::.: |:    ||||     :
Mouse   278 DLEKKTVETEELKNKQTKFLEEIKNQDKLNKSLKEEAMLQKQSCEELESDLSTKKELLKQKTVEL 342

  Fly   283 NKALQTIY 290
            .:|.|..|
Mouse   343 TRACQKQY 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sds22	NP_650619.1	leucine-rich repeat	43..62	CDD:275380
		LRR_8	61..117	CDD:290566	20/50 (40%)
		leucine-rich repeat	63..84	CDD:275380	6/14 (43%)
		LRR_4	83..125	CDD:289563	17/44 (39%)
		leucine-rich repeat	85..106	CDD:275380	7/23 (30%)
		LRR_8	105..183	CDD:290566	32/82 (39%)
		leucine-rich repeat	107..128	CDD:275380	12/20 (60%)
		LRR_4	128..168	CDD:289563	14/44 (32%)
		leucine-rich repeat	129..150	CDD:275380	6/20 (30%)
		LRR_4	149..189	CDD:289563	16/47 (34%)
		leucine-rich repeat	151..172	CDD:275380	8/25 (32%)
		leucine-rich repeat	173..194	CDD:275380	9/23 (39%)
		LRR_8	194..249	CDD:290566	17/77 (22%)
		LRR_4	194..235	CDD:289563	14/57 (25%)
		leucine-rich repeat	195..216	CDD:275380	8/28 (29%)
		leucine-rich repeat	217..238	CDD:275380	6/29 (21%)
Cntrl	NP_001366203.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..70
		PPP1R42	89..261	CDD:411060	57/175 (33%)
		leucine-rich repeat	100..119	CDD:275378	4/19 (21%)
		LRR 1	126..147		11/20 (55%)
		leucine-rich repeat	127..148	CDD:275380	12/20 (60%)
		LRR 2	148..169		6/20 (30%)
		leucine-rich repeat	149..170	CDD:275380	6/20 (30%)
		LRR 3	170..191		8/23 (35%)
		leucine-rich repeat	171..194	CDD:275380	8/25 (32%)
		LRR 4	194..215		7/20 (35%)
		leucine-rich repeat	195..219	CDD:275380	9/23 (39%)
		leucine-rich repeat	220..246	CDD:275380	7/25 (28%)
		Smc	<270..602	CDD:224117	24/81 (30%)
		Smc	440..>1134	CDD:224117
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..562
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	751..771
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1154..1198
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1213..1245
		Drf_FH1	<1239..1310	CDD:399386
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1338..1360
		SMC_prok_B	1407..2216	CDD:274008
		Required for centrosome localization. /evidence=ECO:0000250	1951..2121
		Sufficient for interaction with HOOK2. /evidence=ECO:0000250	1988..2334
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2291..2334
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810