DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sds22 and cdc11

DIOPT Version :9

Sequence 1:	NP_650619.1	Gene:	sds22 / 42091	FlyBaseID:	FBgn0028992	Length:	326	Species:	Drosophila melanogaster
Sequence 2:	NP_588419.1	Gene:	cdc11 / 2539149	PomBaseID:	SPCC1739.11c	Length:	1045	Species:	Schizosaccharomyces pombe

Alignment Length:	390	Identity:	96/390 - (24%)
Similarity:	162/390 - (41%)	Gaps:	101/390 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GDADRAMNEPEAAKTVSGIQVIPAEDVASIEDIITIDP---DCYELDLNHRRIEKLENFEPL-TR 62
            |...:|..:.|.:.:||...:|..     :.|:...:|   ...:||::.|.::.|.....| ..
pombe   568 GLKSKADKDAEYSFSVSRQSIIQI-----LSDVEPYEPFWKRIIQLDISRRHLDSLIGLSELCPS 627

  Fly    63 IERLFLRWNLI-----------------KKIENLSSLKTLIELELYD---NQITKIENLDDLPHL 107
            ||.|.|..|.|                 .::.:|:|...|:.|:..|   ||:..:..|..|.||
pombe   628 IEELTLEGNEIAYLTGCPVTIRDLNAVENRLSSLTSFSNLLNLQYLDISYNQLEDLTGLSSLIHL 692

  Fly   108 EVLDISFNRLTK---IENLDKLVK--------------------LEKVYFVSNRITQIENLDMLT 149
            ..|.:..|.|..   |::||.|:|                    ||::...:|.|.:||.:..|.
pombe   693 RELKVDSNHLWSLDGIQHLDGLLKLSACNNRIKELSFTNSNLHRLEELLLGNNEIEEIEEISSLQ 757

  Fly   150 NLTMLELGDNKLKKIENIEMLVNLRQLFLGKNKIAKIENLDTLVNLEILSLQANRIVK---IENL 211
            ||.:|:|.:|||..::..:.:::||.|.:..|.|.::| :|...:|..|.:..||..:   |..|
pombe   758 NLMVLQLDNNKLTNLKASQPMIHLRILRISNNAIHQLE-VDQFPHLRTLYMDLNRFNRPPDIRRL 821

  Fly   212 EKLAN--------------------LRELYVSEN------------GVETIE----NLSENTK-- 238
            ::|.|                    :|.||:|.|            ||..:|    .|.|..|
pombe   822 KRLVNFSFRTQDPEASNFVIQPSLDIRNLYLSNNTFVTLDCKHMFLGVRYLELANVQLKEVPKYI 886

  Fly   239 ------LETLDLAKNRLKGIANLEKLELLEELWLNHNGVDDWKDI-ELLKVNKALQTIYLEYNPL 296
                  |..|||:.|.:..|.:|:.|:::..|:|..|.:...::: ::|...|.|..:.|..|||
pombe   887 ATSMPNLRVLDLSHNYISDIESLKPLQMIHRLYLVGNRIKKMRNLCDILANLKQLNVLDLRMNPL 951

Fly 297 296
pombe 952 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sds22	NP_650619.1	leucine-rich repeat	43..62	CDD:275380	5/19 (26%)
		LRR_8	61..117	CDD:290566	19/75 (25%)
		leucine-rich repeat	63..84	CDD:275380	8/37 (22%)
		LRR_4	83..125	CDD:289563	14/47 (30%)
		leucine-rich repeat	85..106	CDD:275380	7/23 (30%)
		LRR_8	105..183	CDD:290566	28/100 (28%)
		leucine-rich repeat	107..128	CDD:275380	8/23 (35%)
		LRR_4	128..168	CDD:289563	15/59 (25%)
		leucine-rich repeat	129..150	CDD:275380	7/20 (35%)
		LRR_4	149..189	CDD:289563	13/39 (33%)
		leucine-rich repeat	151..172	CDD:275380	6/20 (30%)
		leucine-rich repeat	173..194	CDD:275380	7/20 (35%)
		LRR_8	194..249	CDD:290566	24/101 (24%)
		LRR_4	194..235	CDD:289563	17/79 (22%)
		leucine-rich repeat	195..216	CDD:275380	7/23 (30%)
		leucine-rich repeat	217..238	CDD:275380	10/36 (28%)
cdc11	NP_588419.1	leucine-rich repeat	608..627	CDD:275380	5/18 (28%)
		leucine-rich repeat	628..669	CDD:275380	9/40 (23%)
		LRR_4	648..688	CDD:289563	8/39 (21%)
		LRR_RI	667..952	CDD:238064	75/286 (26%)
		LRR_4	669..710	CDD:289563	12/40 (30%)
		leucine-rich repeat	670..691	CDD:275380	6/20 (30%)
		leucine-rich repeat	714..736	CDD:275380	2/21 (10%)
		leucine-rich repeat	737..758	CDD:275380	7/20 (35%)
		LRR_8	758..812	CDD:290566	17/54 (31%)
		leucine-rich repeat	759..780	CDD:275380	6/20 (30%)
		leucine-rich repeat	781..801	CDD:275380	7/20 (35%)
		leucine-rich repeat	802..823	CDD:275380	6/20 (30%)
		leucine-rich repeat	824..869	CDD:275380	7/44 (16%)
		LRR_8	868..925	CDD:290566	17/56 (30%)
		leucine-rich repeat	870..892	CDD:275380	4/21 (19%)
		LRR_4	891..931	CDD:289563	11/39 (28%)
		leucine-rich repeat	893..914	CDD:275380	8/20 (40%)
		leucine-rich repeat	915..940	CDD:275380	4/24 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900