DRSC/TRiP Functional Genomics Resources

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Protein Alignment sds22 and DNAAF11

DIOPT Version :9

Sequence 1:NP_650619.1 Gene:sds22 / 42091 FlyBaseID:FBgn0028992 Length:326 Species:Drosophila melanogaster
Sequence 2:XP_006716601.2 Gene:DNAAF11 / 23639 HGNCID:16725 Length:472 Species:Homo sapiens


Alignment Length:361 Identity:93/361 - (25%)
Similarity:159/361 - (44%) Gaps:70/361 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 EDIITIDP---DCY-----ELDLNHRRIEKLENFEPLTR-IERLFLRWNLIKKIENLSSLKTLIE 87
            ||:|..:.   ||.     ||.|:.:.||:||:.:...| ::.|:|:.|||.||||:|.||.|..
Human    12 EDLIRRNAEHNDCVIFSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEY 76

  Fly    88 LELYDNQITKIENLDDLPHLEVLDISFN---RLTKIENLDKLVKLEKVYFVSNRITQIENLDMLT 149
            |.|..|.|.|||||:....|..||::.|   .|:.|:||...:.|::::.:.|.....::.....
Human    77 LNLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFV 141

  Fly   150 NLTMLELGDNKLKKIENIEMLVNLRQLFLGKNKI-----------AKI------------ENLD- 190
            ..|:.:|.....|:||..|.:..|:...:.:.:|           ||:            :|.| 
Human   142 VATLPQLKWLDGKEIEPSERIKALQDYSVIEPQIREQEKDHCLKRAKLKEEAQRKHQEEDKNEDK 206

  Fly   191 -----------TLVNLEILSLQANRIVKI-----ENLEKLANLRE---------LYVSENGVETI 230
                       |.:|..:.||::...::.     .|.:||.|..:         |:..|:.:||:
Human   207 RSNAGFDGRWYTDINATLSSLESKDHLQAPDTEEHNTKKLDNSEDDLEFWNKPCLFTPESRLETL 271

  Fly   231 ENL-SENTKLETLDLAKNRLKG----IANLEKLELLEELWLNHNGVDDWKDIEL-LKVNKALQT- 288
            .:: .:..|.|.|...|.::|.    |....|...:.|..::.:..|:.|.|.| |.|.:.:.| 
Human   272 RHMEKQRKKQEKLSEKKKKVKPPRTLITEDGKALNVNEPKIDFSLKDNEKQIILDLAVYRYMDTS 336

  Fly   289 -IYLEYNPLAKDVRYRSK-LRDILPQLQKIDATLCK 322
             |.::..|....|..:.| .:.:||...|.|::..|
Human   337 LIDVDVQPTYVRVMIKGKPFQLVLPAEVKPDSSSAK 372

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sds22NP_650619.1 leucine-rich repeat 43..62 CDD:275380 7/18 (39%)
LRR_8 61..117 CDD:290566 27/59 (46%)
leucine-rich repeat 63..84 CDD:275380 11/20 (55%)
LRR_4 83..125 CDD:289563 19/44 (43%)
leucine-rich repeat 85..106 CDD:275380 10/20 (50%)
LRR_8 105..183 CDD:290566 17/80 (21%)
leucine-rich repeat 107..128 CDD:275380 8/23 (35%)
LRR_4 128..168 CDD:289563 7/39 (18%)
leucine-rich repeat 129..150 CDD:275380 2/20 (10%)
LRR_4 149..189 CDD:289563 10/62 (16%)
leucine-rich repeat 151..172 CDD:275380 6/20 (30%)
leucine-rich repeat 173..194 CDD:275380 7/55 (13%)
LRR_8 194..249 CDD:290566 15/69 (22%)
LRR_4 194..235 CDD:289563 11/55 (20%)
leucine-rich repeat 195..216 CDD:275380 5/25 (20%)
leucine-rich repeat 217..238 CDD:275380 4/30 (13%)
DNAAF11XP_006716601.2 LRR_RI <5..200 CDD:238064 55/187 (29%)
leucine-rich repeat 29..51 CDD:275378 7/21 (33%)
LRR_8 52..104 CDD:290566 25/51 (49%)
LRR_4 52..92 CDD:289563 22/39 (56%)
leucine-rich repeat 52..73 CDD:275378 11/20 (55%)
leucine-rich repeat 74..95 CDD:275378 10/20 (50%)
leucine-rich repeat 96..120 CDD:275378 8/23 (35%)
LRRcap 134..152 CDD:197729 2/17 (12%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0531
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54194
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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