DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sds22 and Lum

DIOPT Version :9

Sequence 1:	NP_650619.1	Gene:	sds22 / 42091	FlyBaseID:	FBgn0028992	Length:	326	Species:	Drosophila melanogaster
Sequence 2:	NP_032550.2	Gene:	Lum / 17022	MGIID:	109347	Length:	338	Species:	Mus musculus

Alignment Length:	316	Identity:	79/316 - (25%)
Similarity:	134/316 - (42%)	Gaps:	87/316 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 DVASIEDIITIDPDCYELDLNHRRIEKLEN--FEPLTRIERLFLRWNLIK--KIEN--LSSLKTL 85
            |...::.:..:.|....|.|.:.:|:.::.  ||.:|.::.|.|..||::  ||:.  .|.||.|
Mouse    54 DDLKLKSVPMVPPGIKYLYLRNNQIDHIDEKAFENVTDLQWLILDHNLLENSKIKGKVFSKLKQL 118

  Fly    86 IELELYDNQITKIENLDDLP-HLEVLDISFNRLTKIENLDKLVKLEKVYFVSNRITQ---IENLD 146
            .:|.:..|.:|  |::..|| .|:.|.::.|:::|:.:.|.||.|..:|...|::.:   ..:|.
Mouse   119 KKLHINYNNLT--ESVGPLPKSLQDLQLTNNKISKLGSFDGLVNLTFIYLQHNQLKEDAVSASLK 181

  Fly   147 MLTNLTMLELGDNKLKKIENIEMLVNLRQLFLGKNKIAKI--ENLDTLVNLEILSLQANRIVKIE 209
            .|.:|..|:|..|::.|:. ..:..:|..|:|..|||:.|  |.......|:.|.|..|.:
Mouse   182 GLKSLEYLDLSFNQMSKLP-AGLPTSLLTLYLDNNKISNIPDEYFKRFTGLQYLRLSHNEL---- 241

  Fly   210 NLEKLANLRELYVSENGVE----TIENLSENTKLETLDLAKNRLKGIANLEKLELLEELWLNHNG 270
                         :::||.    .|.:|.|      |||:.|:||.|..
Mouse   242 -------------ADSGVPGNSFNISSLLE------LDLSYNKLKSIPT---------------- 271

  Fly   271 VDDWKDIELLKVNKALQTIYLEYNPLAK-DVRYRSKLRDILPQLQKIDATLCKVPG 325
                       ||:.|:..|||.|.|.| ||:                 :.||:.|
Mouse   272 -----------VNENLENYYLEVNELEKFDVK-----------------SFCKILG 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sds22	NP_650619.1	leucine-rich repeat	43..62	CDD:275380	5/20 (25%)
		LRR_8	61..117	CDD:290566	20/60 (33%)
		leucine-rich repeat	63..84	CDD:275380	8/24 (33%)
		LRR_4	83..125	CDD:289563	12/42 (29%)
		leucine-rich repeat	85..106	CDD:275380	7/21 (33%)
		LRR_8	105..183	CDD:290566	22/81 (27%)
		leucine-rich repeat	107..128	CDD:275380	6/20 (30%)
		LRR_4	128..168	CDD:289563	10/42 (24%)
		leucine-rich repeat	129..150	CDD:275380	5/23 (22%)
		LRR_4	149..189	CDD:289563	13/41 (32%)
		leucine-rich repeat	151..172	CDD:275380	5/20 (25%)
		leucine-rich repeat	173..194	CDD:275380	8/22 (36%)
		LRR_8	194..249	CDD:290566	13/58 (22%)
		LRR_4	194..235	CDD:289563	8/44 (18%)
		leucine-rich repeat	195..216	CDD:275380	4/20 (20%)
		leucine-rich repeat	217..238	CDD:275380	5/24 (21%)
Lum	NP_032550.2	LRRNT	37..71	CDD:214470	2/16 (13%)
		LRR_RI	<66..267	CDD:238064	61/226 (27%)
		LRR_8	66..128	CDD:290566	19/61 (31%)
		LRR 1	67..88		4/20 (20%)
		leucine-rich repeat	68..91	CDD:275380	5/22 (23%)
		LRR 2	91..114		6/22 (27%)
		leucine-rich repeat	92..117	CDD:275380	8/24 (33%)
		LRR_8	116..171	CDD:290566	18/56 (32%)
		LRR 3	117..137		6/21 (29%)
		leucine-rich repeat	118..138	CDD:275380	7/21 (33%)
		LRR 4	138..159		5/20 (25%)
		leucine-rich repeat	139..160	CDD:275380	6/20 (30%)
		LRR_8	160..217	CDD:290566	14/57 (25%)
		LRR 5	160..181		3/20 (15%)
		leucine-rich repeat	161..185	CDD:275380	5/23 (22%)
		LRR 6	185..205		5/20 (25%)
		leucine-rich repeat	186..206	CDD:275380	5/20 (25%)
		LRR_8	205..266	CDD:290566	21/83 (25%)
		LRR 7	206..227		8/20 (40%)
		leucine-rich repeat	207..230	CDD:275380	8/22 (36%)
		LRR 8	230..250		6/36 (17%)
		leucine-rich repeat	231..255	CDD:275380	7/40 (18%)
		LRR 9	255..276		11/53 (21%)
		leucine-rich repeat	276..305	CDD:275380	12/41 (29%)
		LRR 10	277..296		8/35 (23%)
		LRR 11	305..326
		leucine-rich repeat	306..329	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D968788at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920