DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sds22 and CNTRL

DIOPT Version :9

Sequence 1:NP_650619.1 Gene:sds22 / 42091 FlyBaseID:FBgn0028992 Length:326 Species:Drosophila melanogaster
Sequence 2:XP_011516468.1 Gene:CNTRL / 11064 HGNCID:1858 Length:2340 Species:Homo sapiens


Alignment Length:271 Identity:79/271 - (29%)
Similarity:138/271 - (50%) Gaps:66/271 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    72 LIKKI---ENLSSLKTLIELELYDN---QITKIENLDDLPHLEVLDISFNRLTKIENLDKLVKLE 130
            ||||:   :||:.:|:| .|.|..:   :...||||:....||||::|:|.:.|||.||||:||.
Human    87 LIKKLTKQDNLALIKSL-NLSLSKDGGKKFKYIENLEKCVKLEVLNLSYNLIGKIEKLDKLLKLR 150

  Fly   131 KVYFVSNRITQIENLDMLTNLTMLELGDNKLKKIENIEMLVNLRQLFLGKNKIAKIENLDTLVNL 195
            ::....|:|::||.::.:.||..|.|..|:::.|          .::|||.          |.:|
Human   151 ELNLSYNKISKIEGIENMCNLQKLNLAGNEIEHI----------PVWLGKK----------LKSL 195

  Fly   196 EILSLQANRIVKIENLEKLANLRE---LYVSENGVETIENLSENT-----KLETLD----LAKNR 248
            .:|:|:.|:|..::::.||..|::   |.:.||.|.|:.:..:.|     .||:|:    ..::|
Human   196 RVLNLKGNKISSLQDISKLKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDR 260

  Fly   249 LKGIA--NLEKLELLEELWLNHNGVDDWKDIELLKVN----KALQTIYLEYNPLAKDVRYRSKLR 307
            .:...  :||::|.||            :|:|...:.    |:.||.:||      :::.:.||.
Human   261 QEAFERFSLEEVERLE------------RDLEKKMIETEELKSKQTRFLE------EIKNQDKLN 307

  Fly   308 DILPQ---LQK 315
            ..|.:   |||
Human   308 KSLKEEAMLQK 318

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sds22NP_650619.1 leucine-rich repeat 43..62 CDD:275380
LRR_8 61..117 CDD:290566 20/50 (40%)
leucine-rich repeat 63..84 CDD:275380 6/14 (43%)
LRR_4 83..125 CDD:289563 18/44 (41%)
leucine-rich repeat 85..106 CDD:275380 7/23 (30%)
LRR_8 105..183 CDD:290566 28/77 (36%)
leucine-rich repeat 107..128 CDD:275380 13/20 (65%)
LRR_4 128..168 CDD:289563 12/39 (31%)
leucine-rich repeat 129..150 CDD:275380 5/20 (25%)
LRR_4 149..189 CDD:289563 9/39 (23%)
leucine-rich repeat 151..172 CDD:275380 5/20 (25%)
leucine-rich repeat 173..194 CDD:275380 4/20 (20%)
LRR_8 194..249 CDD:290566 17/66 (26%)
LRR_4 194..235 CDD:289563 13/43 (30%)
leucine-rich repeat 195..216 CDD:275380 7/20 (35%)
leucine-rich repeat 217..238 CDD:275380 7/28 (25%)
CNTRLXP_011516468.1 leucine-rich repeat 100..119 CDD:275378 4/19 (21%)
LRR_4 126..167 CDD:289563 19/40 (48%)
leucine-rich repeat 127..148 CDD:275380 13/20 (65%)
LRR_8 148..205 CDD:290566 20/76 (26%)
leucine-rich repeat 149..170 CDD:275380 5/20 (25%)
LRR_4 169..213 CDD:289563 15/63 (24%)
leucine-rich repeat 171..194 CDD:275380 9/42 (21%)
leucine-rich repeat 195..219 CDD:275380 8/23 (35%)
leucine-rich repeat 220..246 CDD:275380 6/25 (24%)
SMC_prok_B <435..1119 CDD:274008
DUF342 <513..610 CDD:302792
Pro-rich <1176..1299 CDD:291893
COG4372 1320..>1602 CDD:226809
Mplasa_alph_rch 1525..2221 CDD:275316
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0531
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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