DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sds22 and LRRC23

DIOPT Version :9

Sequence 1:	NP_650619.1	Gene:	sds22 / 42091	FlyBaseID:	FBgn0028992	Length:	326	Species:	Drosophila melanogaster
Sequence 2:	NP_001128689.1	Gene:	LRRC23 / 10233	HGNCID:	19138	Length:	343	Species:	Homo sapiens

Alignment Length:	325	Identity:	83/325 - (25%)
Similarity:	135/325 - (41%)	Gaps:	79/325 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 DPDCYELDLNHRRIEKLENFE-------------PLTRIERLFLRWNLIKKIENLSSL-KT---- 84
            |.|..|.:.:.:..|:.|::.             |||.        :::|  |.||.| ||
Human    13 DQDDSEKEEDEKETEEGEDYRKEGEEFPEEWLPTPLTE--------DMMK--EGLSLLCKTGNGL 67

  Fly    85 ---LIELELYDNQITKIENLDDLPHLEVLDISFNRLTKIENLDKLVKL----------------E 130
               .::||:.:..:|.|..|....||..:|||.|.||.:..|:.|..|                |
Human    68 AHAYVKLEVKERDLTDIYLLRSYIHLRYVDISENHLTDLSPLNYLTHLLWLKADGNRLRSAQMNE 132

  Fly   131 KVY-----FVSNRITQIENLDMLTNLTMLELGDNKLKKIENI--EMLVNLRQLFLGKNKIAKIEN 188
            ..|     |..|:||..|.:.. ..|..|.|..|.:..:..:  |.|::|..:.|..|::.....
Human   133 LPYLQIASFAYNQITDTEGISH-PRLETLNLKGNSIHMVTGLDPEKLISLHTVELRGNQLESTLG 196

  Fly   189 LDTLVNLEILSLQANRIVKIENLEKLANLRELYVSENGVETIENLSENTK-LETLDLAKNRLKGI 252
            :: |..|:.|.|..|.:.|:|.||.|:||..|::.:|.::|:...|...| |:.|:|..|.   :
Human   197 IN-LPKLKNLYLAQNMLKKVEGLEDLSNLTTLHLRDNQIDTLSGFSREMKSLQYLNLRGNM---V 257

  Fly   253 ANLEKLELLEELWLNHNGVDDWKDIELLKVNKALQTIYLEYNPLAKDVRYRSKLRDILPQLQKID 317
            |||.:|..|.:|                   ..|:.:.|..||...:..||.:....:|.|:::|
Human   258 ANLGELAKLRDL-------------------PKLRALVLLDNPCTDETSYRQEALVQMPYLERLD 303

Fly 318 317
Human 304 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sds22	NP_650619.1	leucine-rich repeat	43..62	CDD:275380	5/31 (16%)
		LRR_8	61..117	CDD:290566	19/63 (30%)
		leucine-rich repeat	63..84	CDD:275380	5/21 (24%)
		LRR_4	83..125	CDD:289563	16/48 (33%)
		leucine-rich repeat	85..106	CDD:275380	5/20 (25%)
		LRR_8	105..183	CDD:290566	27/100 (27%)
		leucine-rich repeat	107..128	CDD:275380	9/20 (45%)
		LRR_4	128..168	CDD:289563	12/62 (19%)
		leucine-rich repeat	129..150	CDD:275380	8/41 (20%)
		LRR_4	149..189	CDD:289563	9/41 (22%)
		leucine-rich repeat	151..172	CDD:275380	6/22 (27%)
		leucine-rich repeat	173..194	CDD:275380	4/20 (20%)
		LRR_8	194..249	CDD:290566	20/55 (36%)
		LRR_4	194..235	CDD:289563	14/40 (35%)
		leucine-rich repeat	195..216	CDD:275380	9/20 (45%)
		leucine-rich repeat	217..238	CDD:275380	5/20 (25%)
LRRC23	NP_001128689.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47		5/33 (15%)
		LRR 1	92..113		9/20 (45%)
		leucine-rich repeat	93..114	CDD:275380	9/20 (45%)
		LRR 2	114..134		2/19 (11%)
		leucine-rich repeat	115..135	CDD:275380	2/19 (11%)
		LRR 3	135..155		6/20 (30%)
		leucine-rich repeat	136..156	CDD:275380	5/20 (25%)
		LRR 4	156..177		4/20 (20%)
		leucine-rich repeat	157..180	CDD:275380	6/22 (27%)
		LRR 5	180..200		3/20 (15%)
		leucine-rich repeat	181..201	CDD:275380	4/20 (20%)
		LRR_8	200..255	CDD:290566	19/54 (35%)
		LRR_4	200..241	CDD:289563	14/40 (35%)
		LRR 6	201..222		8/20 (40%)
		leucine-rich repeat	202..223	CDD:275380	9/20 (45%)
		LRR_4	223..265	CDD:289563	15/44 (34%)
		LRR 7	223..244		6/20 (30%)
		leucine-rich repeat	224..246	CDD:275380	5/21 (24%)
		LRR 8	246..267		8/23 (35%)
		leucine-rich repeat	247..271	CDD:275380	10/45 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..343
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54194
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820