DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lute and Btbd1

DIOPT Version :9

Sequence 1:	NP_001262663.1	Gene:	lute / 42089	FlyBaseID:	FBgn0262871	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_666305.2	Gene:	Btbd1 / 83962	MGIID:	1933765	Length:	488	Species:	Mus musculus

Alignment Length:	441	Identity:	203/441 - (46%)
Similarity:	286/441 - (64%)	Gaps:	20/441 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 NWQASKATVLERNAAMFNNELMSDVKFIVG---GEFDIDPIQTIPAHKYILATGSSVFYAMFYGG 251
            ||||:||::.||.|.:||:||:|||:|::|   |.......|.||||:::||.||:||.|||.||
Mouse    53 NWQATKASLKERFAFLFNSELLSDVRFVLGKGRGAAAAGGPQRIPAHRFVLAAGSAVFDAMFNGG 117

  Fly   252 LAENKQEIKVPDVEPTAFLTLLRYLYCDEIKLEPEHILATLYAAKKYIVPHLARACVNYLEVKLT 316
            :|....||::|||||.|||.|||:||.||:::.||.::.|||.||||.||.|...||.:|...|.
Mouse   118 MATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLR 182

  Fly   317 AKNACLLLSQSRLFEEPELMQRCWEVIDAQAEMAVKSEDFVDIDLKTFESILSRETLNCKEIHLF 381
            |.||.:||:|:|||:||:|...|.:.||.....|:.:|.|.|||:.|..::|.|:||:.:|..||
Mouse   183 ADNAFMLLTQARLFDEPQLASLCLDTIDKSTVDAISAEGFTDIDIDTLCAVLERDTLSIRESRLF 247

  Fly   382 EAALNWAMNACEKMSIDDTPQNKRRLLGQALHLIRIPTMSLEEFANGVAQTGILSSQETIDMFLH 446
            .|.:.||...|::..:..|..||:::||:||.|||.|.|::||||.|.||:||||.:|.:::|||
Mouse   248 GAIVRWAEAECQRQQLAVTFGNKQKVLGKALSLIRFPLMTIEEFAAGPAQSGILSDREVVNLFLH 312

  Fly   447 FTAKMKPSLGFPTRSRAGLKTQVC--HRFQSCAYRSNQWRYRGRCDSIQFSVDRRIFIVGFGLYG 509
            ||...||.:.:..|.|..|:.:.|  :|||..   .::|.|.|..|.|:|:|:|||.:|||||||
Mouse   313 FTVNPKPRVEYIDRPRCCLRGKECCINRFQQV---ESRWGYSGTSDRIRFTVNRRISVVGFGLYG 374

  Fly   510 SSTGAANYNVKIEL----KRLGRTLAENDTKFFSDGSSNTFHVFFENPIQIEPECYYTASVILDG 570
            |..|..:|.|.|::    |:  :||.:|||.|..||::|||.|.|:.||:|.|...|||...|.|
Mouse   375 SIHGPTDYQVNIQIIEYEKK--QTLGQNDTGFSCDGTANTFRVMFKEPIEILPNVCYTACATLKG 437

  Fly   571 NELSFFGQEGMSEVL-----MGNVTFQFQCSSESTNGTGVQGGQIPELIFY 616
            .: |.:|.:|:.:|:     .....|.|..|..:.|||.::.|||||:|||
Mouse   438 PD-SHYGTKGLKKVVHETPAASKTVFLFFSSPGNNNGTSIEDGQIPEIIFY 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lute	NP_001262663.1	BTB	204..311	CDD:279045	58/109 (53%)
		BTB	213..315	CDD:197585	54/104 (52%)
		BACK	321..427	CDD:197943	45/105 (43%)
		PHR	472..615	CDD:285277	63/151 (42%)
Btbd1	NP_666305.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42
		BTB	68..177	CDD:279045	58/108 (54%)
		BTB	94..181	CDD:197585	49/86 (57%)
		BACK	193..292	CDD:197943	41/98 (42%)
		PHR	340..486	CDD:285277	63/151 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2075
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000758
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3806
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840