DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lute and btbd3a

DIOPT Version :9

Sequence 1:	NP_001262663.1	Gene:	lute / 42089	FlyBaseID:	FBgn0262871	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_001139053.1	Gene:	btbd3a / 563691	ZFINID:	ZDB-GENE-090312-7	Length:	461	Species:	Danio rerio

Alignment Length:	461	Identity:	296/461 - (64%)
Similarity:	357/461 - (77%)	Gaps:	9/461 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 PTSGSGSYVCSAGTNWHFAAVAASNAIDTADPNWQASKATVLERNAAMFNNELMSDVKFIVGGEF 222
            ||....:...||...:....|:.:|.|...  |||....|:.|||:.|||||||:|:.|:||
Zfish     7 PTKKLPTVSASAVQQFQQQNVSNNNTIQGC--NWQGLYPTIRERNSVMFNNELMADIHFVVG--- 66

  Fly   223 DIDP--IQTIPAHKYILATGSSVFYAMFYGGLAENKQEIKVPDVEPTAFLTLLRYLYCDEIKLEP 285
              .|  .|.:|.|||:||.|||||:|||||.|||:|.||::|||||.:||.:|:|:|||||.|..
Zfish    67 --PPGGTQRVPGHKYVLAVGSSVFHAMFYGELAEDKDEIRIPDVEPPSFLAMLKYIYCDEIDLCA 129

  Fly   286 EHILATLYAAKKYIVPHLARACVNYLEVKLTAKNACLLLSQSRLFEEPELMQRCWEVIDAQAEMA 350
            :.:|||||||||||||||||||||:||..|:|:|||:|||||.|||||:|.||||||||||||:|
Zfish   130 DTVLATLYAAKKYIVPHLARACVNFLETSLSARNACVLLSQSCLFEEPDLTQRCWEVIDAQAELA 194

  Fly   351 VKSEDFVDIDLKTFESILSRETLNCKEIHLFEAALNWAMNACEKMSIDDTPQNKRRLLGQALHLI 415
            ::||.|.|||.:|.||||.|||||.||:.:|||.|:||...|.:..:..|.:|||.:||::::||
Zfish   195 LRSEGFCDIDTQTLESILRRETLNAKEMVVFEATLSWAEAECHRQELQPTIENKRLVLGKSIYLI 259

  Fly   416 RIPTMSLEEFANGVAQTGILSSQETIDMFLHFTAKMKPSLGFPTRSRAGLKTQVCHRFQSCAYRS 480
            |||.|:|::|||||||:|:|:..||.|:||.:||..||.|.|..:.|.||..|.|||||||||||
Zfish   260 RIPAMALDDFANGVAQSGVLTLNETNDIFLWYTAAKKPELKFVCKPRKGLTPQKCHRFQSCAYRS 324

  Fly   481 NQWRYRGRCDSIQFSVDRRIFIVGFGLYGSSTGAANYNVKIELKRLGRTLAENDTKFFSDGSSNT 545
            ||||||||||||||:||:|:||.||||||||.|:|.|..||||||.|.||.....|:||||||||
Zfish   325 NQWRYRGRCDSIQFAVDKRVFIAGFGLYGSSCGSAEYQAKIELKRQGVTLGIAIIKYFSDGSSNT 389

  Fly   546 FHVFFENPIQIEPECYYTASVILDGNELSFFGQEGMSEVLMGNVTFQFQCSSESTNGTGVQGGQI 610
            |.||||.|:||||:.:|||||||||||||:||||||:||..|.|||||||||:||||||||||||
Zfish   390 FSVFFEYPVQIEPDTFYTASVILDGNELSYFGQEGMTEVQCGKVTFQFQCSSDSTNGTGVQGGQI 454

  Fly   611 PELIFY 616
            ||||||
Zfish   455 PELIFY 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lute	NP_001262663.1	BTB	204..311	CDD:279045	71/108 (66%)
		BTB	213..315	CDD:197585	66/103 (64%)
		BACK	321..427	CDD:197943	64/105 (61%)
		PHR	472..615	CDD:285277	113/142 (80%)
btbd3a	NP_001139053.1	BTB	52..155	CDD:279045	71/107 (66%)
		BTB	60..159	CDD:197585	66/103 (64%)
		BACK	165..271	CDD:197943	64/105 (61%)
		PHR	316..459	CDD:285277	113/142 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576635
Domainoid	1	1.000	246	1.000	Domainoid score	I2128
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	599	1.000	Inparanoid score	I922
OMA	1	1.010	-	-		QHG46950
OrthoDB	1	1.010	-	-		D294162at33208
OrthoFinder	1	1.000	-	-		FOG0000758
OrthoInspector	1	1.000	-	-		otm25538
orthoMCL	1	0.900	-	-		OOG6_100034
Panther	1	1.100	-	-	O	PTHR45774
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3806
SonicParanoid	1	1.000	-	-		X1485
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.900