DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lute and KLHL11

DIOPT Version :9

Sequence 1:	NP_001262663.1	Gene:	lute / 42089	FlyBaseID:	FBgn0262871	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_060613.1	Gene:	KLHL11 / 55175	HGNCID:	19008	Length:	708	Species:	Homo sapiens

Alignment Length:	363	Identity:	69/363 - (19%)
Similarity:	139/363 - (38%)	Gaps:	70/363 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 SAAADHNIQITQPISAPSSPLASPGALNSSGSSSGGGAGSAGGISGSPTAFCLPSSSAAAAVAAI 154
            :|||..::|:.:              :.|..:::.|.||.|..:.||.|....| ....:|:.|.
Human    11 AAAAAASLQVLE--------------MESMETAAAGSAGLAAEVRGSGTVDFGP-GPGISAMEAS 60

  Fly   155 SATPTSGSGSYVCSAGTNWHFAAVAASNAIDTADPNWQASKATVLERNAAMFNNELMSDVKFIVG 219
            ...|...:..:.||:               ..::.:|:.::    :|...:|     .|:....|
Human    61 GGDPGPEAEDFECSS---------------HCSELSWRQNE----QRRQGLF-----CDITLCFG 101

  Fly   220 G----EFDIDPIQTIPAHKYILATGSSVFYAMFYGGLAENKQ---EIK----VPDVEPTAFLTLL 273
            |    ||        .||:.:||..:..|..:..|..:|::.   |::    .|..||.....::
Human   102 GAGGREF--------RAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWSSEPGPEPDTVEAVI 158

  Fly   274 RYLYCDEIKLEPEHILATLYAAKKYIVPHLARACVNYLEVKLTAKNACLLLSQSRLFEEPELMQR 338
            .|:|...|::....:...|..|.::::..|...|..:|:.||...|...:.|.:.::...:|..:
Human   159 EYMYTGRIRVSTGSVHEVLELADRFLLIRLKEFCGEFLKKKLHLSNCVAIHSLAHMYTLSQLALK 223

  Fly   339 CWEVIDAQAEMAVKSEDFVDIDLKTFESILS--RETLNCKEIHLFEAALNWAMNACEKMSIDDTP 401
            ..::|.......::.|:|..:........||  ..|::.:|: |||..|.|.....|:
Human   224 AADMIRRNFHKVIQDEEFYTLPFHLIRDWLSDLEITVDSEEV-LFETVLKWVQRNAEE------- 280

  Fly   402 QNKRRLLGQALHLIRIPTMSLEEFANGVAQTGILSSQE 439
              :.|...:...|:|:..|........|....::::.|
Human   281 --RERYFEELFKLLRLSQMKPTYLTRHVKPERLVANNE 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lute	NP_001262663.1	BTB	204..311	CDD:279045	24/117 (21%)
		BTB	213..315	CDD:197585	24/112 (21%)
		BACK	321..427	CDD:197943	19/107 (18%)
		PHR	472..615	CDD:285277
KLHL11	NP_060613.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	47..70		4/23 (17%)
		BTB_POZ_KLHL11	71..205	CDD:349550	31/165 (19%)
		PHA03098	90..553	CDD:222983	49/250 (20%)
		BACK_KLHL11	200..287	CDD:350526	18/96 (19%)
		Kelch 1	360..407
		KELCH repeat	399..439	CDD:276965
		Kelch 2	408..453
		KELCH repeat	443..488	CDD:276965
		Kelch 3	455..501
		KELCH repeat	491..541	CDD:276965
		Kelch 4	503..556
		KELCH repeat	567..649	CDD:276965
		Kelch 5	610..661
		Kelch	611..657	CDD:128874
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143715
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840