DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lute and BTBD1

DIOPT Version :9

Sequence 1:	NP_001262663.1	Gene:	lute / 42089	FlyBaseID:	FBgn0262871	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_079514.1	Gene:	BTBD1 / 53339	HGNCID:	1120	Length:	482	Species:	Homo sapiens

Alignment Length:	521	Identity:	216/521 - (41%)
Similarity:	306/521 - (58%)	Gaps:	54/521 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 LASPGALNSSGSSSGGGAGSAGGISGSPTAFCLPSSSAAAAVAAISATPTSGSGSYVCSAGTNWH 174
            :||.|.  ::......||.:..|.:|.|..   ||.|:...:..:...|..
Human     1 MASLGP--AAAGEQASGAEAEPGPAGPPPP---PSPSSLGPLLPLQREPLY-------------- 46

  Fly   175 FAAVAASNAIDTADPNWQASKATVLERNAAMFNNELMSDVKFIVG---GEFDIDPIQTIPAHKYI 236
                           ||||:||::.||.|.:||:||:|||:|::|   |.......|.||||:::
Human    47 ---------------NWQATKASLKERFAFLFNSELLSDVRFVLGKGRGAAAAGGPQRIPAHRFV 96

  Fly   237 LATGSSVFYAMFYGGLAENKQEIKVPDVEPTAFLTLLRYLYCDEIKLEPEHILATLYAAKKYIVP 301
            ||.||:||.|||.||:|....||::|||||.|||.|||:||.||:::.||.::.|||.||||.||
Human    97 LAAGSAVFDAMFNGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVP 161

  Fly   302 HLARACVNYLEVKLTAKNACLLLSQSRLFEEPELMQRCWEVIDAQAEMAVKSEDFVDIDLKTFES 366
            .|...||.:|...|.|.||.:||:|:|||:||:|...|.:.||.....|:.:|.|.|||:.|..:
Human   162 ALEAHCVEFLTKHLRADNAFMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDTLCA 226

  Fly   367 ILSRETLNCKEIHLFEAALNWAMNACEKMSIDDTPQNKRRLLGQALHLIRIPTMSLEEFANGVAQ 431
            :|.|:||:.:|..||.|.:.||...|::..:..|..||:::||:||.|||.|.|::||||.|.||
Human   227 VLERDTLSIRESRLFGAVVRWAEAECQRQQLPVTFGNKQKVLGKALSLIRFPLMTIEEFAAGPAQ 291

  Fly   432 TGILSSQETIDMFLHFTAKMKPSLGFPTRSRAGLKTQVC--HRFQSCAYRSNQWRYRGRCDSIQF 494
            :||||.:|.:::|||||...||.:.:..|.|..|:.:.|  :|||..   .::|.|.|..|.|:|
Human   292 SGILSDREVVNLFLHFTVNPKPRVEYIDRPRCCLRGKECCINRFQQV---ESRWGYSGTSDRIRF 353

  Fly   495 SVDRRIFIVGFGLYGSSTGAANYNVKIEL----KRLGRTLAENDTKFFSDGSSNTFHVFFENPIQ 555
            :|:|||.|||||||||..|..:|.|.|::    |:  :||.:|||.|..||::|||.|.|:.||:
Human   354 TVNRRISIVGFGLYGSIHGPTDYQVNIQIIEYEKK--QTLGQNDTGFSCDGTANTFRVMFKEPIE 416

  Fly   556 IEPECYYTASVILDGNELSFFGQEGMSEVL-----MGNVTFQFQCSSESTNGTGVQGGQIPELIF 615
            |.|...|||...|.|.: |.:|.:|:.:|:     .....|.|..|..:.|||.::.|||||:||
Human   417 ILPNVCYTACATLKGPD-SHYGTKGLKKVVHETPAASKTVFFFFSSPGNNNGTSIEDGQIPEIIF 480

  Fly   616 Y 616
            |
Human   481 Y 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lute	NP_001262663.1	BTB	204..311	CDD:279045	58/109 (53%)
		BTB	213..315	CDD:197585	54/104 (52%)
		BACK	321..427	CDD:197943	45/105 (43%)
		PHR	472..615	CDD:285277	64/151 (42%)
BTBD1	NP_079514.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36		11/39 (28%)
		BTB	62..175	CDD:306997	59/112 (53%)
		BACK	187..286	CDD:197943	41/98 (42%)
		PHR	334..480	CDD:311801	64/151 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2075
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000758
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3806
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840